ZHANG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZHANG_HUMAN
• UniProt AC: Q9NS37
• Protein Name: CREB/ATF bZIP transcription factor
• Gene Name: CREBZF
• Organism: Homo sapiens (Human).
• Sequence Length: 354
• Subcellular Localization: Nucleus . Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-NB) with CREB3 and HCFC1.
• Protein Description: Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells..
• Protein Sequence: MRHSLTKLLAASGSNSPTRSESPEPAATCSLPSDLTRAAAGEEETAAAGSPGRKQQFGDEGELEAGRGSRGGVAVRAPSPEEMEEEAIASLPGEETEDMDFLSGLELADLLDPRQPDWHLDPGLSSPGPLSSSGGGSDSGGLWRGDDDDEAAAAEMQRFSDLLQRLLNGIGGCSSSSDSGSAEKRRRKSPGGGGGGGSGNDNNQAATKSPRKAAAAAARLNRLKKKEYVMGLESRVRGLAAENQELRAENRELGKRVQALQEESRYLRAVLANETGLARLLSRLSGVGLRLTTSLFRDSPAGDHDYALPVGKQKQDLLEEDDSAGGVCLHVDKDKVSVEFCSACARKASSSLKM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	LTKLLAASGSNSPTR HHHHHHHCCCCCCCC	36.83	22167270
14	Phosphorylation	KLLAASGSNSPTRSE HHHHHCCCCCCCCCC	31.47	22167270
16	Phosphorylation	LAASGSNSPTRSESP HHHCCCCCCCCCCCC	29.37	29255136
18	Phosphorylation	ASGSNSPTRSESPEP HCCCCCCCCCCCCCC	46.80	29255136
20	Phosphorylation	GSNSPTRSESPEPAA CCCCCCCCCCCCCCC	44.92	30278072
22	Phosphorylation	NSPTRSESPEPAATC CCCCCCCCCCCCCCC	35.49	30278072
28	Phosphorylation	ESPEPAATCSLPSDL CCCCCCCCCCCCHHH	12.53	25850435
30	Phosphorylation	PEPAATCSLPSDLTR CCCCCCCCCCHHHHH	38.67	25850435
33	Phosphorylation	AATCSLPSDLTRAAA CCCCCCCHHHHHHHH	51.01	23927012
36	Phosphorylation	CSLPSDLTRAAAGEE CCCCHHHHHHHHCCH	24.21	23927012
45	Phosphorylation	AAAGEEETAAAGSPG HHHCCHHHHHCCCCC	25.52	29978859
50	Phosphorylation	EETAAAGSPGRKQQF HHHHHCCCCCCCHHC	21.32	29255136
54	Acetylation	AAGSPGRKQQFGDEG HCCCCCCCHHCCCCC	55.13	26051181
133	Phosphorylation	SPGPLSSSGGGSDSG CCCCCCCCCCCCCCC	37.77	22210691
174	Phosphorylation	LNGIGGCSSSSDSGS HHCCCCCCCCCCCCC	36.21	21712546
179	Phosphorylation	GCSSSSDSGSAEKRR CCCCCCCCCCCHHHC	36.27	21712546
181	Phosphorylation	SSSSDSGSAEKRRRK CCCCCCCCCHHHCCC	36.89	21815630
184	Acetylation	SDSGSAEKRRRKSPG CCCCCCHHHCCCCCC	51.42	26051181
184	Ubiquitination	SDSGSAEKRRRKSPG CCCCCCHHHCCCCCC	51.42	-
189	Phosphorylation	AEKRRRKSPGGGGGG CHHHCCCCCCCCCCC	27.28	29255136
198	Phosphorylation	GGGGGGGSGNDNNQA CCCCCCCCCCCCCCC	37.38	23403867
207	Phosphorylation	NDNNQAATKSPRKAA CCCCCCCCCCHHHHH	34.76	23403867
208	Acetylation	DNNQAATKSPRKAAA CCCCCCCCCHHHHHH	54.45	25953088
208	Ubiquitination	DNNQAATKSPRKAAA CCCCCCCCCHHHHHH	54.45	-
209	Phosphorylation	NNQAATKSPRKAAAA CCCCCCCCHHHHHHH	26.11	26074081
275	Phosphorylation	RAVLANETGLARLLS HHHHHCHHHHHHHHH	36.98	24670416
282	Phosphorylation	TGLARLLSRLSGVGL HHHHHHHHHHHCCCH	35.45	-
285	Phosphorylation	ARLLSRLSGVGLRLT HHHHHHHHCCCHHHH	30.26	-
294	Phosphorylation	VGLRLTTSLFRDSPA CCHHHHHHHHCCCCC	21.92	21712546
299	Phosphorylation	TTSLFRDSPAGDHDY HHHHHCCCCCCCCCC	16.64	21712546
312	Ubiquitination	DYALPVGKQKQDLLE CCCCCCCHHHHHHHH	55.33	2190698
312	Acetylation	DYALPVGKQKQDLLE CCCCCCCHHHHHHHH	55.33	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:11238952

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZHANG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZHANG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HCFC1_HUMAN	HCFC1	physical	10871379
HCFC1_HUMAN	HCFC1	physical	15705566
NF2L1_HUMAN	NFE2L1	physical	23661758
ATF4_HUMAN	ATF4	physical	23661758
XBP1_HUMAN	XBP1	physical	23661758
ZHANG_HUMAN	CREBZF	physical	23661758
TTC23_HUMAN	TTC23	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.