TEX15_HUMAN - dbPTM
TEX15_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TEX15_HUMAN
UniProt AC Q9BXT5
Protein Name Testis-expressed protein 15
Gene Name TEX15
Organism Homo sapiens (Human).
Sequence Length 2789
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair..
Protein Sequence MPSDAKDSVNGDLLLNWTSLKNILSGLNASFPLHNNTGSSTVTTSKSIKDPRLMRREESMGEQSSTAGLNEVLQFEKSSDNVNSEIKSTPSNSASSSEVVPGDCAVLTNGLDTPCFKTSVNDSQSWAHNMGSEDYDCIPPNKVTMAGQCKDQGNFSFPISVSNVVSEVENQNHSEEKAQRAQQESGNAYTKEYSSHIFQDSQSSDLKTIYQTGCQTSTVFPLKKKVSIDEYLQNTGKMKNFADLEDSSKHEEKQTSWKEIDNDFTNETKISPIDNYIVLHQEYKESESHNSFGKSCDKILITQELEITKSSTSTIKDKDELDHLALEWQITPSFESLSQKHPQHSVEYEGNIHTSLAIAQKLMELKLGKINQNYASIITEAFPKPKDIPQAKEMFIDTVISSYNIETAHDSSNCSITREHICVHRKNENEPVSLENIQRDYKETAYVEDRGQDHNLFCNSQLSNDIWLNVNFKKQTDRENQNEAKENSASCVENNIENIYGDKKQDSHTNENFSNIDEKEDKNYHNIEILSSEEFSTKFNLICREDNAVSAATALLESEEDTISAVKQKDTENTGRSVEHLASTTFPKTASSSVCVASNAAIQIASATMPALSLNNDDHQIYQFKETCSSESPDFGLLVKHRVSDCEIDTDKNKSQESFHQSINENLVLQSIELESEIEIELEDCDDAFIFQQDTHSHENMLCEEFVTSYKALKSRISWEGLLALDNGEMEVLESTTGRENSDQHYSKESNYFYSSTQNNETELTSPILLPDLQIKITNIFRPGFSPTADSLALKDSFCTHVTEATKPEINKEDGEILGFDIYSQPFGENADYPCEDKVDNIRQESGPVSNSEISLSFDLSRNTDVNHTSENQNSESLFTEPSNVTTIDDGSRCFFTKSKTDYNDTKNKKEVESRISKRKLHISSRDQNIPHKDLRRHKIYGRKRRLTSQDSSECFSSLSQGRIKTFSQSEKHIKSVLNILSDEASLCKSKCLSRKLDKAVVHLKKAHRRVHTSLQLITKVGEERKGPLPKSYAIICNNFWESCDLQGYSSVSQRKYYSTKHFSSKRKYDKRRKKRAPKADISKSLTHVSKHKSYKTSGEKKCLSRKSMASSVSKSHPTTSHMGEFCNQEHPESQLPVSSTSQSTSQSVYYNSSVSNPSLSEEHQPFSGKTAYLFSPDHSDEKLIEKENQIDTAFLSSTSKYEKLEKHSANHNVKDATKENSCDANEVINESNSVSLSCIKENINSSTGNDCDATCIGHTKAKTDVLISVLDSNVKHFLNDLYQQGNLILSDCKRNLEVKWTDPIERPKQNIITGNFLMGPLNLTLIASKKYSIPQLSAAAVTDSEGESSKSYLDKQRILTVDSFAASSTVPHCEQSCREKELLKTEQCSSGNCLHTDGNETNVTENYELDVASGTEEDKSYGENIVELSSSDSSLLLKDNVKGSSSETCIVKKDTEDRITWKVKQAEKAKDSVYKRSMTEGSTVNTEYKNQKNQISEESCLNEKIITTNLIDSHLSTKNTTTESVPLKNTVSNPLNKREKKGEIKVSKDSQSDLTLHSEIAYISKPGILGVNHTPILPAHSETCKVPTLLKKPASYVSDFKEKHCSANHTALIANLSQILQRADEASSLQILQEETKVCLNILPLFVEAFERKQECSVEQILISRELLVDQNLWNNCKHTLKPCAVDTLVELQMMMETIQFIENKKRHLEGEPTLRSLLWYDETLYAELLGKPRGFQQQSNFYPGFQGRLKYNAFCELQTYHDQLVELLEETKREKNSYYVFLKYKRQVNECEAIMEHCSDCFDFSLSVPFTCGVNFGDSLEDLEILRKSTLKLINVCGDSPKVHSYPGKQDHLWIIIEMISSKVNFIKNNEAVRVKISLYGLEHIFFDAAKNLVWKERTQSFSKKYSQKKDEERLLRVNKCAFSKLQKIYDTLSKDLNNEPISPIGLEEDTIIASRKSDHPINEATISIENSKFNSNLLAHPDICCISEILDQAEFADLKKLQDLTLRCTDHLEILKKYFQMLQDNNMDNIFITEENVLDVVINHSHEAIILKPEAIEMYIEIVMVSETIHFLKNSIAKKLDKQRFRGMLWFDLSLLPELVQCQEKMASFSFLKDNSTDVCLWKVIETAVSELKKDLDIICKYNEAVNCSYAIHLLSRELQELSEIKKLLKKSKYFISTYIDFVPYIASINYGSTVTELEYNYNQFSTLLKNVMSAPRKDLGKMAHIRKVMKTIEHMKMICTKNAELTISFFLCQMLYNRRKILQLKRKEKMNIHIVKPGENNNKFSISTMLPPVSECINKNISNSSKKRPSTVDKCEDSQEQQQDTTVSSCKKLKVDMKDVTKINREKATFKHPRTTGSHPKSENKIVPSSCDSLKRNHLTPKKVEMQRSLPGSLLPLENPKDTCASKSESKIDLTVSSDHFSGQQENLNSMKKRNVNFSAAETKSDKKDCAAFAICDQKSVHGTFSPDHGTLLQKFLKNSPDPTQKSCLSDINPETDVSLVPDASVLSKPIFCFVKDVHPDLEMNDTVFELQDNDIVNSSIKNSSCMTSPEPICIQNKIPTLQINKLQPTETESEDKYMKDTLNPNTVHTFGASGHITLNVNQGAEYSLSEQQNDKNSKVLMQNAATYWNELPQSACNPTYNSSEHLFGTSYPYSAWCVYQYSNSNGNAITQTYQGITSYEVQPSPSGLLTTVASTAQGTHSNLLYSQYFTYFAGEPQANGFVPVNGYFQSQIPASNFRQPIFSQYASHQPLPQATYPYLPNRFVPPEVPWVYAPWHQESFHPGH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MPSDAKDSVN
-----CCCCHHCCCC		63.16-
18PhosphorylationGDLLLNWTSLKNILS
CCEEECHHHHHHHHH		24.10-
19PhosphorylationDLLLNWTSLKNILSG
CEEECHHHHHHHHHC		29.03-
118PhosphorylationLDTPCFKTSVNDSQS
CCCCCEECCCCCHHH		20.0430576142
132PhosphorylationSWAHNMGSEDYDCIP
HHHHHCCCCCCCCCC		19.2730576142
193PhosphorylationGNAYTKEYSSHIFQD
CCCCHHHHHHHCCCC		19.61-
218PhosphorylationQTGCQTSTVFPLKKK
HCCCCCCCEEECCCC		29.5629759185
295PhosphorylationSHNSFGKSCDKILIT
CCCCCCCCCCEEEEE		28.1128355574
308PhosphorylationITQELEITKSSTSTI
EEEEEEEECCCCCCC		18.5924670416
374PhosphorylationLGKINQNYASIITEA
CCCCCCCHHHHHHHC		7.61-
376PhosphorylationKINQNYASIITEAFP
CCCCCHHHHHHHCCC		12.26-
379PhosphorylationQNYASIITEAFPKPK
CCHHHHHHHCCCCCC		21.42-
488PhosphorylationQNEAKENSASCVENN
HHHHHHHHHHHHHHC		23.7325072903
490PhosphorylationEAKENSASCVENNIE
HHHHHHHHHHHHCHH		20.6525072903
500PhosphorylationENNIENIYGDKKQDS
HHCHHHHHCCCCCCC		30.7425072903
514PhosphorylationSHTNENFSNIDEKED
CCCCCCCCCCCHHHC		44.45-
524PhosphorylationDEKEDKNYHNIEILS
CHHHCCCCCCEEECC		11.2829759185
899PhosphorylationSRCFFTKSKTDYNDT
CEEEEECCCCCCCCC		37.4222985185
903PhosphorylationFTKSKTDYNDTKNKK
EECCCCCCCCCCCHH		21.85-
906PhosphorylationSKTDYNDTKNKKEVE
CCCCCCCCCCHHHHH		32.6422985185
948PhosphorylationYGRKRRLTSQDSSEC
HCCCCCCCCCCHHHH		23.64-
949PhosphorylationGRKRRLTSQDSSECF
CCCCCCCCCCHHHHH		36.26-
1005AcetylationDKAVVHLKKAHRRVH
HHHHHHHHHHHHHHH		32.7920167786
1006AcetylationKAVVHLKKAHRRVHT
HHHHHHHHHHHHHHH		56.6420167786
1013PhosphorylationKAHRRVHTSLQLITK
HHHHHHHHHHHHHHH		28.4229083192
1014PhosphorylationAHRRVHTSLQLITKV
HHHHHHHHHHHHHHH		10.1529083192
1019PhosphorylationHTSLQLITKVGEERK
HHHHHHHHHHCCCCC		28.4129083192
1193PhosphorylationEKENQIDTAFLSSTS
HHHHHCCHHHHCCCH		22.4226074081
1197PhosphorylationQIDTAFLSSTSKYEK
HCCHHHHCCCHHHHH		25.7226074081
1198PhosphorylationIDTAFLSSTSKYEKL
CCHHHHCCCHHHHHH		38.5626074081
1199PhosphorylationDTAFLSSTSKYEKLE
CHHHHCCCHHHHHHH		26.3426074081
1200PhosphorylationTAFLSSTSKYEKLEK
HHHHCCCHHHHHHHH		34.8826074081
1202PhosphorylationFLSSTSKYEKLEKHS
HHCCCHHHHHHHHHH		20.3326074081
1232PhosphorylationANEVINESNSVSLSC
HHHHHCCCCCEEHHH		29.8924719451
1471AcetylationVKQAEKAKDSVYKRS
EEHHHHHCCCCHHHH		62.707910753
1473PhosphorylationQAEKAKDSVYKRSMT
HHHHHCCCCHHHHCC		27.0029978859
1475PhosphorylationEKAKDSVYKRSMTEG
HHHCCCCHHHHCCCC		12.4929978859
1478PhosphorylationKDSVYKRSMTEGSTV
CCCCHHHHCCCCCCC		26.3829978859
1480PhosphorylationSVYKRSMTEGSTVNT
CCHHHHCCCCCCCCH		38.1426503514
1484PhosphorylationRSMTEGSTVNTEYKN
HHCCCCCCCCHHHHC		28.73-
1489PhosphorylationGSTVNTEYKNQKNQI
CCCCCHHHHCCCCCC		17.13-
1508PhosphorylationCLNEKIITTNLIDSH
HHCCHHHHHHHHHHH		17.07-
1509PhosphorylationLNEKIITTNLIDSHL
HCCHHHHHHHHHHHC		20.02-
1514PhosphorylationITTNLIDSHLSTKNT
HHHHHHHHHCCCCCC		21.23-
1517PhosphorylationNLIDSHLSTKNTTTE
HHHHHHCCCCCCCCC		31.73-
1522PhosphorylationHLSTKNTTTESVPLK
HCCCCCCCCCCCCCC		37.6523532336
1525PhosphorylationTKNTTTESVPLKNTV
CCCCCCCCCCCCCCC		27.2623532336
1559PhosphorylationQSDLTLHSEIAYISK
CCCCEEEEEEEECCC		33.54-
1779PhosphorylationETKREKNSYYVFLKY
HHCCCCCEEEEEEEE		28.9829083192
1780PhosphorylationTKREKNSYYVFLKYK
HCCCCCEEEEEEEEH		17.0329083192
1781PhosphorylationKREKNSYYVFLKYKR
CCCCCEEEEEEEEHH		5.6429083192
1786PhosphorylationSYYVFLKYKRQVNEC
EEEEEEEEHHCHHHH		17.3529083192
1831PhosphorylationDLEILRKSTLKLINV
HHHHHHHHHCHHEEC		32.3226434552
1832PhosphorylationLEILRKSTLKLINVC
HHHHHHHHCHHEECC		30.8326434552
1901O-linked_GlycosylationNLVWKERTQSFSKKY
HHHHHHHHHHHHHHH		29.6530379171
1903PhosphorylationVWKERTQSFSKKYSQ
HHHHHHHHHHHHHCC		30.7624719451
1932PhosphorylationFSKLQKIYDTLSKDL
HHHHHHHHHHHCHHC		15.2023532336
2113PhosphorylationQEKMASFSFLKDNST
HHHHHCCHHCCCCCC		27.4624719451
2133PhosphorylationKVIETAVSELKKDLD
HHHHHHHHHHHHCCH		34.4524114839
2235PhosphorylationHIRKVMKTIEHMKMI
HHHHHHHHHHHHHHH		17.32-
2322PhosphorylationTVDKCEDSQEQQQDT
CCCCCCCCHHHHCCC		17.2129978859
2329PhosphorylationSQEQQQDTTVSSCKK
CHHHHCCCCHHHHHC		25.4329978859
2330PhosphorylationQEQQQDTTVSSCKKL
HHHHCCCCHHHHHCC		27.0429978859
2332PhosphorylationQQQDTTVSSCKKLKV
HHCCCCHHHHHCCCC		28.1129978859
2333PhosphorylationQQDTTVSSCKKLKVD
HCCCCHHHHHCCCCC		26.1429978859
2345PhosphorylationKVDMKDVTKINREKA
CCCHHHHHHHHHHHC		36.0229083192
2362PhosphorylationKHPRTTGSHPKSENK
CCCCCCCCCCCCCCC		34.23-
2419PhosphorylationSESKIDLTVSSDHFS
CCCCEEEEEECCCCC		18.0024043423
2421PhosphorylationSKIDLTVSSDHFSGQ
CCEEEEEECCCCCCC		25.4724043423
2422PhosphorylationKIDLTVSSDHFSGQQ
CEEEEEECCCCCCCH		30.6724043423
2436AcetylationQENLNSMKKRNVNFS
HHHHHHHHHHCCCCC		48.6918586819
2443O-linked_GlycosylationKKRNVNFSAAETKSD
HHHCCCCCHHCCCCC		22.7430379171
2484PhosphorylationLQKFLKNSPDPTQKS
HHHHHHCCCCCCHHH		29.14-
2488PhosphorylationLKNSPDPTQKSCLSD
HHCCCCCCHHHHCCC		56.88-
2548PhosphorylationVNSSIKNSSCMTSPE
CCCCCCCCCCCCCCC		21.6617924679
2549PhosphorylationNSSIKNSSCMTSPEP
CCCCCCCCCCCCCCC		19.8017924679
2578PhosphorylationLQPTETESEDKYMKD
CCCCCCCCHHHHHHH		59.5225627689
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TEX15_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TEX15_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TEX15_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TEX15_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TEX15_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2548 AND SER-2549, ANDMASS SPECTROMETRY.

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