SYT10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYT10_HUMAN
• UniProt AC: Q6XYQ8
• Protein Name: Synaptotagmin-10
• Gene Name: SYT10
• Organism: Homo sapiens (Human).
• Sequence Length: 523
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein . Localizes to neuronal vesicles containing IGF1 that are not enriched at synapses. Does not colocalize with synaptic vesicles or with the Golgi apparatus.
• Protein Description: Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity)..
• Protein Sequence: MSFHKEDGVNSLCQKALHIVTELCFAGQVEWEKCSGIFPRDRGSQGGSSTDISVSLLAVVVSFCGLALLVVSLFVFWKLCWPCWKSKPVTSNITTLPQSISSAPTEVFETEEKKEIKENEKPAVKAIEPAIKISHTSPDIPAEVQTALKEHLIKHARVQRQITEPTSSTRHSSFRRHLPRQMQVSSVDFSMGTEPVLQRGETTTSIGRIKPELYKQKSVDSEGNQNEDVKICGKLNFTLQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKMYLLPDRKKKFQTRVHRKTLNPLFDETFQFPVAYDQLSNRKLHFSVYDFDRFSRHDMIGEVILDNLFEVSDLSREATVWKDIHCATTESIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLSIAVMDYDRVGHNEVIGVCRTGLDAEGLGRDHWNEMLAYHRKPITHWHPLLELPGRATSFDSQGSCPSPKPPSTP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	RGSQGGSSTDISVSL CCCCCCCCCHHHHHH	33.11	28387310
136	Phosphorylation	PAIKISHTSPDIPAE CCEECCCCCCCCCHH	34.85	-
185	Phosphorylation	LPRQMQVSSVDFSMG CCCCCEEEEEECCCC	14.04	30206219
186	Phosphorylation	PRQMQVSSVDFSMGT CCCCEEEEEECCCCC	27.18	30206219
190	Phosphorylation	QVSSVDFSMGTEPVL EEEEEECCCCCCCCC	16.31	30206219
203	Phosphorylation	VLQRGETTTSIGRIK CCCCCCCCCCHHCCC	17.78	-
204	Phosphorylation	LQRGETTTSIGRIKP CCCCCCCCCHHCCCH	26.26	-
218	Phosphorylation	PELYKQKSVDSEGNQ HHHHHCCCCCCCCCC	28.76	27135362
317	Phosphorylation	SNRKLHFSVYDFDRF CCCEEEEEEECCCCC	14.71	24076635
398	Phosphorylation	KAMDITGSSDPYVKV CCEECCCCCCCCEEE	23.94	30631047
399	Phosphorylation	AMDITGSSDPYVKVS CEECCCCCCCCEEEE	43.90	30631047
419	Phosphorylation	RRLKKRKTTTKKNTL CCCCCCCCCCCCCCC	43.67	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYT10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYT10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYT10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYT10_HUMAN	SYT10	physical	10531343

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.