GALK1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GALK1_HUMAN
• UniProt AC: P51570
• Protein Name: Galactokinase
• Gene Name: GALK1
• Organism: Homo sapiens (Human).
• Sequence Length: 392
• Protein Description: Major enzyme for galactose metabolism..
• Protein Sequence: MAALRQPQVAELLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELMTVLVGSPRKDGLVSLLTTSEGADEPQRLQFPLPTAQRSLEPGTPRWANYVKGVIQYYPAAPLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQLCPDSGTIAARAQVCQQAEHSFAGMPCGIMDQFISLMGQKGHALLIDCRSLETSLVPLSDPKLAVLITNSNVRHSLASSEYPVRRRQCEEVARALGKESLREVQLEELEAARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDYRAFGRLMVESHRSLRDDYEVSCPELDQLVEAALAVPGVYGSRMTGGGFGGCTVTLLEASAAPHAMRHIQEHYGGTATFYLSQAADGAKVLCL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	VNLIGEHTDYNQGLV EEEECCCCCCCCCCH	35.56	24043423
47	Phosphorylation	LIGEHTDYNQGLVLP EECCCCCCCCCCHHH	15.56	24043423
61	Phosphorylation	PMALELMTVLVGSPR HHHHHHHHHHHCCCC	24.26	28450419
66	Phosphorylation	LMTVLVGSPRKDGLV HHHHHHCCCCCCCCE	17.66	28450419
69	Ubiquitination	VLVGSPRKDGLVSLL HHHCCCCCCCCEEEE	60.58	21890473
94	Phosphorylation	RLQFPLPTAQRSLEP CCCCCCCCCHHCCCC	43.00	20068231
217	Ubiquitination	LVPLSDPKLAVLITN EEECCCCCEEEEEEC	54.81	21890473
223	Phosphorylation	PKLAVLITNSNVRHS CCEEEEEECCCHHHH	28.56	21406692
225	Phosphorylation	LAVLITNSNVRHSLA EEEEEECCCHHHHHC	28.22	21406692
230	Phosphorylation	TNSNVRHSLASSEYP ECCCHHHHHCCCCCC	18.31	11139256
233	Phosphorylation	NVRHSLASSEYPVRR CHHHHHCCCCCCCCH	29.06	28270605
234	Phosphorylation	VRHSLASSEYPVRRR HHHHHCCCCCCCCHH	35.23	28270605
236	Phosphorylation	HSLASSEYPVRRRQC HHHCCCCCCCCHHHH	14.69	28270605
252	Ubiquitination	EVARALGKESLREVQ HHHHHHCCHHHHHHH	45.00	-
272	Ubiquitination	AARDLVSKEGFRRAR HHHHHHHHHHHHHHH	55.14	21890473
282	Ubiquitination	FRRARHVVGEIRRTA HHHHHHHHHHHHHHH	4.68	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GALK1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GALK1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GALK1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
KCRU_HUMAN	CKMT1B	physical	26344197
GALM_HUMAN	GALM	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 230200: Galactosemia II (GALCT2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.