GALM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GALM_HUMAN
• UniProt AC: Q96C23
• Protein Name: Aldose 1-epimerase
• Gene Name: GALM
• Organism: Homo sapiens (Human).
• Sequence Length: 342
• Subcellular Localization: Cytoplasm .
• Protein Description: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)..
• Protein Sequence: MASVTRAVFGELPSGGGTVEKFQLQSDLLRVDIISWGCTITALEVKDRQGRASDVVLGFAELEGYLQKQPYFGAVIGRVANRIAKGTFKVDGKEYHLAINKEPNSLHGGVRGFDKVLWTPRVLSNGVQFSRISPDGEEGYPGELKVWVTYTLDGGELIVNYRAQASQATPVNLTNHSYFNLAGQASPNINDHEVTIEADTYLPVDETLIPTGEVAPVQGTAFDLRKPVELGKHLQDFHLNGFDHNFCLKGSKEKHFCARVHHAASGRVLEVYTTQPGVQFYTGNFLDGTLKGKNGAVYPKHSGFCLETQNWPDAVNQPRFPPVLLRPGEEYDHTTWFKFSVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASVTRAVF ------CCCHHHHHH	16.83	19413330
14	Phosphorylation	AVFGELPSGGGTVEK HHHCCCCCCCCCEEE	63.80	28857561
18	Phosphorylation	ELPSGGGTVEKFQLQ CCCCCCCCEEEEEEC	28.85	28857561
21	Ubiquitination	SGGGTVEKFQLQSDL CCCCCEEEEEECCCC	33.79	-
68	Ubiquitination	ELEGYLQKQPYFGAV HHHHHHHHCCCHHHH	51.12	-
85	Ubiquitination	RVANRIAKGTFKVDG HHHHHHHCEEEEECC	56.99	-
93	Ubiquitination	GTFKVDGKEYHLAIN EEEEECCEEEEEEEC	51.11	-
101	Acetylation	EYHLAINKEPNSLHG EEEEEECCCCCCCCC	69.32	7430741
101	Ubiquitination	EYHLAINKEPNSLHG EEEEEECCCCCCCCC	69.32	-
115	Ubiquitination	GGVRGFDKVLWTPRV CCCCCCCCEEECCEE	36.65	-
119	Phosphorylation	GFDKVLWTPRVLSNG CCCCEEECCEEECCC	9.32	-
124	Phosphorylation	LWTPRVLSNGVQFSR EECCEEECCCEEEEE	28.78	28857561
161	Phosphorylation	GGELIVNYRAQASQA CCEEEEEEEEECCCC	9.09	-
226	Ubiquitination	GTAFDLRKPVELGKH CCEEECCCCHHHHHH	61.79	-
291	Ubiquitination	NFLDGTLKGKNGAVY CCCCCCEECCCCCEE	68.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GALM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GALM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GALM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATOX1_HUMAN	ATOX1	physical	26344197
GALK2_HUMAN	GALK2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330