SGMR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SGMR2_HUMAN
• UniProt AC: Q5BJF2
• Protein Name: Sigma intracellular receptor 2 {ECO:0000305}
• Gene Name: TMEM97 {ECO:0000312|HGNC:HGNC:28106}
• Organism: Homo sapiens (Human).
• Sequence Length: 176
• Subcellular Localization: Nucleus membrane ; Multi-pass membrane protein . Rough endoplasmic reticulum membrane ; Multi-pass membrane protein . Localized at cell membrane and in lysosomes in sterol-depleted cells when expression of endogenous TMEM97 is stimulated.
• Protein Description: Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells. [PubMed: 28559337 Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation]
• Protein Sequence: MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Ubiquitination	VEFRNLLKWYAKEFK HHHHHHHHHHHHHCC		27667366
48	2-Hydroxyisobutyrylation	VEFRNLLKWYAKEFK HHHHHHHHHHHHHCC		-
52	Ubiquitination	NLLKWYAKEFKDPLL HHHHHHHHHCCCHHH		21890473
55	Ubiquitination	KWYAKEFKDPLLQEP HHHHHHCCCHHHCCC		21890473
87	Ubiquitination	FFPIATYAFLKGSCK CCCHHHHHHHHCCCH		21890473
91	Ubiquitination	ATYAFLKGSCKWIRT HHHHHHHCCCHHCCC		21890473
94	Ubiquitination	AFLKGSCKWIRTPAI HHHHCCCHHCCCCHH		21890473
103	Phosphorylation	IRTPAIIYSVHTMTT CCCCHHHHHHHHHHH		-
108	Sulfoxidation	IIYSVHTMTTLIPIL HHHHHHHHHHHHHHH		28183972
109	Phosphorylation	IYSVHTMTTLIPILS HHHHHHHHHHHHHHH		28270605
110	Phosphorylation	YSVHTMTTLIPILST HHHHHHHHHHHHHHH		28270605
116	Phosphorylation	TTLIPILSTFLFEDF HHHHHHHHHHHHCCH		28270605
117	Phosphorylation	TLIPILSTFLFEDFS HHHHHHHHHHHCCHH		28270605
124	Phosphorylation	TFLFEDFSKASGFKG HHHHCCHHHHCCCCC		28270605
125	Ubiquitination	FLFEDFSKASGFKGQ HHHCCHHHHCCCCCC		22817900
130	Ubiquitination	FSKASGFKGQRPETL HHHHCCCCCCCCCCH		27667366
164	Ubiquitination	LLIFMLRSPYYKYEE HHHHHHHCCCHHHHH		22817900
168	Ubiquitination	MLRSPYYKYEEKRKK HHHCCCHHHHHHHHC		27667366
169	Ubiquitination	LRSPYYKYEEKRKKK HHCCCHHHHHHHHCC		21890473
207	Ubiquitination	-------------------------------------- --------------------------------------		27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SGMR2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SGMR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SGMR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
STXB3_HUMAN	STXBP3	physical	26186194
KGUA_HUMAN	GUK1	physical	26186194
STXB3_HUMAN	STXBP3	physical	28514442
KGUA_HUMAN	GUK1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.