OTUL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OTUL_HUMAN
• UniProt AC: Q96BN8
• Protein Name: Ubiquitin thioesterase otulin {ECO:0000305}
• Gene Name: OTULIN {ECO:0000303|PubMed:23806334, ECO:0000312|HGNC:HGNC:25118}
• Organism: Homo sapiens (Human).
• Sequence Length: 352
• Subcellular Localization: Cytoplasm .
• Protein Description: Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. [PubMed: 23708998]
• Protein Sequence: MSRGTMPQPEAWPGASCAETPAREAAATARDGGKAAASGQPRPEMQCPAEHEEDMYRAADEIEKEKELLIHERGASEPRLSVAPEMDIMDYCKKEWRGNTQKATCMKMGYEEVSQKFTSIRRVRGDNYCALRATLFQAMSQAVGLPPWLQDPELMLLPEKLISKYNWIKQWKLGLKFDGKNEDLVDKIKESLTLLRKKWAGLAEMRTAEARQIACDELFTNEAEEYSLYEAVKFLMLNRAIELYNDKEKGKEVPFFSVLLFARDTSNDPGQLLRNHLNQVGHTGGLEQVEMFLLAYAVRHTIQVYRLSKYNTEEFITVYPTDPPKDWPVVTLIAEDDRHYNIPVRVCEETSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	PGASCAETPAREAAA CCCCCCCCHHHHHHH		28555341
31	Ubiquitination	EAAATARDGGKAAAS HHHHHHHCCCCCCCC		23000965
34	Ubiquitination	ATARDGGKAAASGQP HHHHCCCCCCCCCCC		21963094
38	Phosphorylation	DGGKAAASGQPRPEM CCCCCCCCCCCCCCC		28555341
56	Phosphorylation	AEHEEDMYRAADEIE CCCHHHHHHHHHHHH		28674151
64	Ubiquitination	RAADEIEKEKELLIH HHHHHHHHHHHHHHH		23000965
66	Ubiquitination	ADEIEKEKELLIHER HHHHHHHHHHHHHCC		23000965
76	Phosphorylation	LIHERGASEPRLSVA HHHCCCCCCCCCCCC		25159151
91	Ubiquitination	PEMDIMDYCKKEWRG CCCCHHHHHHHHHCC		22817900
93	Ubiquitination	MDIMDYCKKEWRGNT CCHHHHHHHHHCCCC		32015554
94	Ubiquitination	DIMDYCKKEWRGNTQ CHHHHHHHHHCCCCC		-
95	Ubiquitination	IMDYCKKEWRGNTQK HHHHHHHHHCCCCCH		22817900
102	Ubiquitination	EWRGNTQKATCMKMG HHCCCCCHHHHHHCC		29967540
104	Phosphorylation	RGNTQKATCMKMGYE CCCCCHHHHHHCCHH		-
107	Ubiquitination	TQKATCMKMGYEEVS CCHHHHHHCCHHHHH		32015554
110	Phosphorylation	ATCMKMGYEEVSQKF HHHHHCCHHHHHHHH		27642862
116	Ubiquitination	GYEEVSQKFTSIRRV CHHHHHHHHHCHHHH		23000965
119	Phosphorylation	EVSQKFTSIRRVRGD HHHHHHHCHHHHCCC		29496963
164	Acetylation	LPEKLISKYNWIKQW CCHHHHHHCCHHHHH		25953088
164	Ubiquitination	LPEKLISKYNWIKQW CCHHHHHHCCHHHHH		29967540
169	Ubiquitination	ISKYNWIKQWKLGLK HHHCCHHHHHHCCCE		29967540
176	Ubiquitination	KQWKLGLKFDGKNED HHHHCCCEECCCCHH		22817900
176	Acetylation	KQWKLGLKFDGKNED HHHHCCCEECCCCHH		12433833
180	Ubiquitination	LGLKFDGKNEDLVDK CCCEECCCCHHHHHH		21906983
180	Acetylation	LGLKFDGKNEDLVDK CCCEECCCCHHHHHH		12433843
187	Acetylation	KNEDLVDKIKESLTL CCHHHHHHHHHHHHH		12433853
187	Ubiquitination	KNEDLVDKIKESLTL CCHHHHHHHHHHHHH		29967540
189	2-Hydroxyisobutyrylation	EDLVDKIKESLTLLR HHHHHHHHHHHHHHH		-
189	Ubiquitination	EDLVDKIKESLTLLR HHHHHHHHHHHHHHH		29967540
193	Phosphorylation	DKIKESLTLLRKKWA HHHHHHHHHHHHHHH		24260401
244	Phosphorylation	LNRAIELYNDKEKGK HHHHHHHHCCHHCCC		-
247	2-Hydroxyisobutyrylation	AIELYNDKEKGKEVP HHHHHCCHHCCCCCC		-
257	Phosphorylation	GKEVPFFSVLLFARD CCCCCCEEEEEEECC		-
305	Phosphorylation	VRHTIQVYRLSKYNT HHHHHHHEECCCCCC		-
350	Phosphorylation	PVRVCEETSL----- CCEEEECCCC-----		28060719
351	Phosphorylation	VRVCEETSL------ CEEEECCCC------		28060719

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OTUL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OTUL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OTUL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_HUMAN	UBC	physical	23746843
UBC_HUMAN	UBC	physical	23708998
RNF31_HUMAN	RNF31	physical	23708998
HOIL1_HUMAN	RBCK1	physical	23708998
DVL2_HUMAN	DVL2	physical	23708998
RNF31_HUMAN	RNF31	physical	24726327
HOIL1_HUMAN	RBCK1	physical	24726327
UBC_HUMAN	UBC	physical	24726327
TERA_HUMAN	VCP	physical	24726323
RNF31_HUMAN	RNF31	physical	24726323
HOIL1_HUMAN	RBCK1	physical	24726323
SHRPN_HUMAN	SHARPIN	physical	24726323
UBC_HUMAN	UBC	physical	23827681
SBP1_HUMAN	SELENBP1	physical	26186194
DUS14_HUMAN	DUSP14	physical	26186194
LRC15_HUMAN	LRRC15	physical	26186194
UBC_HUMAN	UBC	physical	25527291
RNF31_HUMAN	RNF31	physical	26670046
HOIL1_HUMAN	RBCK1	physical	26670046
SHRPN_HUMAN	SHARPIN	physical	26670046
BCL10_HUMAN	BCL10	physical	27777308
LAMP2_HUMAN	LAMP2	physical	28514442
DUS14_HUMAN	DUSP14	physical	28514442
RNF31_HUMAN	RNF31	physical	27591049
RNF31_HUMAN	RNF31	physical	28244869
UBC_HUMAN	UBC	physical	28319114

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.