BIN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BIN3_HUMAN
• UniProt AC: Q9NQY0
• Protein Name: Bridging integrator 3
• Gene Name: BIN3
• Organism: Homo sapiens (Human).
• Sequence Length: 253
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Involved in cytokinesis and septation where it has a role in the localization of F-actin..
• Protein Sequence: MSWIPFKIGQPKKQIVPKTVERDFEREYGKLQQLEEQTRRLQKDMKKSTDADLAMSKSAVKISLDLLSNPLCEQDQDLLNMVTALDTAMKRMDAFNQEKVNQIQKTVIEPLKKFGSVFPSLNMAVKRREQALQDYRRLQAKVEKYEEKEKTGPVLAKLHQAREELRPVREDFEAKNRQLLEEMPRFYGSRLDYFQPSFESLIRAQVVYYSEMHKIFGDLSHQLDQPGHSDEQRERENEAKLSELRALSIVADD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Ubiquitination	-MSWIPFKIGQPKKQ -CCCCCCCCCCCCCC	40.34	-
12	Ubiquitination	PFKIGQPKKQIVPKT CCCCCCCCCCCCCCC	49.80	-
18	Ubiquitination	PKKQIVPKTVERDFE CCCCCCCCCCHHHHH	55.07	-
28	Phosphorylation	ERDFEREYGKLQQLE HHHHHHHHHHHHHHH	26.28	29496907
30	Ubiquitination	DFEREYGKLQQLEEQ HHHHHHHHHHHHHHH	42.07	-
47	Ubiquitination	RLQKDMKKSTDADLA HHHHHHHHCCHHHHH	52.53	-
48	Phosphorylation	LQKDMKKSTDADLAM HHHHHHHCCHHHHHH	26.46	18669648
49	Phosphorylation	QKDMKKSTDADLAMS HHHHHHCCHHHHHHC	44.05	18669648
56	Phosphorylation	TDADLAMSKSAVKIS CHHHHHHCHHHHHHH	20.18	18669648
57	Ubiquitination	DADLAMSKSAVKISL HHHHHHCHHHHHHHH	29.38	-
99	Ubiquitination	MDAFNQEKVNQIQKT HHHCCHHHHHHHHHH	36.40	-
105	Ubiquitination	EKVNQIQKTVIEPLK HHHHHHHHHHHHHHH	46.52	-
112	Ubiquitination	KTVIEPLKKFGSVFP HHHHHHHHHHCCCCH	57.69	-
113	Ubiquitination	TVIEPLKKFGSVFPS HHHHHHHHHCCCCHH	63.74	-
126	Ubiquitination	PSLNMAVKRREQALQ HHHHHHHHHHHHHHH	35.88	-
141	Ubiquitination	DYRRLQAKVEKYEEK HHHHHHHHHHHHHHH	37.66	-
157	Ubiquitination	KTGPVLAKLHQAREE CCCHHHHHHHHHHHH	42.20	-
240	Ubiquitination	RERENEAKLSELRAL HHHHHHHHHHHHHHH	46.50	-
242	Phosphorylation	RENEAKLSELRALSI HHHHHHHHHHHHHHH	33.60	29514088
248	Phosphorylation	LSELRALSIVADD-- HHHHHHHHHHCCC--	17.65	29514088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BIN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BIN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BIN3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERH_HUMAN	ERH	physical	17353931
OSBL1_HUMAN	OSBPL1A	physical	26186194
SNX5_HUMAN	SNX5	physical	26186194
ARH37_HUMAN	ARHGEF37	physical	26186194
DNMBP_HUMAN	DNMBP	physical	26186194
SNX1_HUMAN	SNX1	physical	26186194
PICK1_HUMAN	PICK1	physical	26186194
FBX8_HUMAN	FBXO8	physical	28514442
PCM1_HUMAN	PCM1	physical	28514442
SNX5_HUMAN	SNX5	physical	28514442
PX11B_HUMAN	PEX11B	physical	28514442
COG1_HUMAN	COG1	physical	28514442
TF3C6_HUMAN	GTF3C6	physical	28514442
COG7_HUMAN	COG7	physical	28514442
PYGB_HUMAN	PYGB	physical	28514442
TF3C3_HUMAN	GTF3C3	physical	28514442
SEC63_HUMAN	SEC63	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.