ARH37_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARH37_HUMAN
• UniProt AC: A1IGU5
• Protein Name: Rho guanine nucleotide exchange factor 37
• Gene Name: ARHGEF37
• Organism: Homo sapiens (Human).
• Sequence Length: 675
• Protein Description: May act as a guanine nucleotide exchange factor (GEF)..
• Protein Sequence: MAKHGADEPSSRSGSPDREGRASEDRSLLHQRLAVRELIDTEVSYLHMLQLCASDIRSRLQQLPQGDLDVLFSNIDDIIKVNSRFLHDLQETASKEEEQVQLVGNIFLEFQEELEQVYKVYCASYDQALLLVDTYRKEPELQRHIQGIVEAVVPQAGSSGLSFLLVIPLQRITRYPLLLQKILENTVPDASAYPVLQRAVSALQDVNTNINEYKMRKEVASKYTKVEQLTLRERLARINTHTLSKKTTRLSQLLKQEAGLIPRTEDKEFDDLEERFQWVSLCVTELKNNVAAYLDNLQAFLYFRPHEYNLDIPEGPAVQYCNLARDLHLEAFLKFKQRLEGLVWQPLCSLAKALLGPQNLIKKRLDKLLDFERVEEKLLEVGSVTYQEEAARHTYQALNSLLVAELPQFNQLVMQWLGQIMCTFVTLQRDLAKQVLQRAEGSMAQLPHHHVPEPAFRKLVEDALGRTSNQLRSFQETFEKVQPPPTTQPLLPGSERQVQALLSRYGPGKLYQVTSNISGTGTLDLTLPRGQIVAILQNKDTKGNSGRWLVDTGGHRGYVPAGKLQLYHVVPSAEELRRQAGLNKDPRCLTPEPSPALVPSIPTMNQVIAAYPFVARSSHEVSLQAGQPVTILEAQDKKGNPEWSLVEVNGQRGYVPSGFLARARSPVLWGWSLPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	KHGADEPSSRSGSPD CCCCCCCCCCCCCCC	36.01	25002506
11	Phosphorylation	HGADEPSSRSGSPDR CCCCCCCCCCCCCCC	40.98	26437602
13	Phosphorylation	ADEPSSRSGSPDREG CCCCCCCCCCCCCCC	45.64	26437602
15	Phosphorylation	EPSSRSGSPDREGRA CCCCCCCCCCCCCCC	25.52	26437602
175	Phosphorylation	PLQRITRYPLLLQKI EHHHHHCHHHHHHHH	6.92	-
186	Phosphorylation	LQKILENTVPDASAY HHHHHHCCCCCHHHH	24.84	23401153
191	Phosphorylation	ENTVPDASAYPVLQR HCCCCCHHHHHHHHH	35.40	22210691
193	Phosphorylation	TVPDASAYPVLQRAV CCCCHHHHHHHHHHH	7.44	23401153
201	Phosphorylation	PVLQRAVSALQDVNT HHHHHHHHHHHHHCC	23.44	28857561
223	Phosphorylation	RKEVASKYTKVEQLT HHHHHHCCCHHHHHH	14.86	-
240	Phosphorylation	ERLARINTHTLSKKT HHHHHHCHHHHCHHH	17.54	28857561
242	Phosphorylation	LARINTHTLSKKTTR HHHHCHHHHCHHHHH	30.59	28857561
244	Phosphorylation	RINTHTLSKKTTRLS HHCHHHHCHHHHHHH	33.01	23312004
247	Phosphorylation	THTLSKKTTRLSQLL HHHHCHHHHHHHHHH	22.38	23312004
248	Phosphorylation	HTLSKKTTRLSQLLK HHHCHHHHHHHHHHH	38.19	23312004
251	Phosphorylation	SKKTTRLSQLLKQEA CHHHHHHHHHHHHHC	18.58	28857561
383	Phosphorylation	EKLLEVGSVTYQEEA HHHHHHCCEECHHHH	19.23	28857561
511	Phosphorylation	RYGPGKLYQVTSNIS HHCCCCEEEEEECCC	12.38	-
514	Phosphorylation	PGKLYQVTSNISGTG CCCEEEEEECCCCCE	10.67	-
518	Phosphorylation	YQVTSNISGTGTLDL EEEEECCCCCEEEEE	34.25	-
526	Phosphorylation	GTGTLDLTLPRGQIV CCEEEEEEECCCEEE	34.09	24719451
567	Phosphorylation	PAGKLQLYHVVPSAE CCCCEEEEEECCCHH	4.60	23898821
572	Phosphorylation	QLYHVVPSAEELRRQ EEEEECCCHHHHHHH	36.38	23898821
590	Phosphorylation	NKDPRCLTPEPSPAL CCCCCCCCCCCCCCC	29.27	24719451
600	Phosphorylation	PSPALVPSIPTMNQV CCCCCCCCCCCHHHH	33.45	27251275
654	Phosphorylation	EVNGQRGYVPSGFLA EECCEECCCCCCHHH	16.04	-
657	Phosphorylation	GQRGYVPSGFLARAR CEECCCCCCHHHHCC	31.94	-
665	Phosphorylation	GFLARARSPVLWGWS CHHHHCCCCCEECCC	20.55	29507054
672	Phosphorylation	SPVLWGWSLPS---- CCCEECCCCCC----	26.85	28857561
675	Phosphorylation	LWGWSLPS------- EECCCCCC-------	59.14	28102081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARH37_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARH37_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARH37_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ARH37_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.