| UniProt ID | FBX8_HUMAN | |
|---|---|---|
| UniProt AC | Q9NRD0 | |
| Protein Name | F-box only protein 8 | |
| Gene Name | FBXO8 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 319 | |
| Subcellular Localization | ||
| Protein Description | May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential).. | |
| Protein Sequence | MGQGLWRVVRNQQLQQEGYSEQGYLTREQSRRMAASNISNTNHRKQVQGGIDIYHLLKARKSKEQEGFINLEMLPPELSFTILSYLNATDLCLASCVWQDLANDELLWQGLCKSTWGHCSIYNKNPPLGFSFRKLYMQLDEGSLTFNANPDEGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDERRDVLDDLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRAAQNISEDFVGHLYDNIYLIGHVAA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 19 | Phosphorylation | QQLQQEGYSEQGYLT HHHHHCCCCHHCCCC | 14.31 | 24043423 | |
| 20 | Phosphorylation | QLQQEGYSEQGYLTR HHHHCCCCHHCCCCH | 34.01 | 24043423 | |
| 24 | Phosphorylation | EGYSEQGYLTREQSR CCCCHHCCCCHHHHH | 12.47 | 24043423 | |
| 26 | Phosphorylation | YSEQGYLTREQSRRM CCHHCCCCHHHHHHH | 24.55 | 24043423 | |
| 30 | Phosphorylation | GYLTREQSRRMAASN CCCCHHHHHHHHHHC | 19.66 | 29978859 | |
| 131 | Phosphorylation | KNPPLGFSFRKLYMQ CCCCCCCEEEHEEEE | 23.49 | 24719451 | |
| 156 | Phosphorylation | NPDEGVNYFMSKGIL CCCCCHHHHHHCCCC | 9.76 | - | |
| 168 | Ubiquitination | GILDDSPKEIAKFIF CCCCCCHHHHHHHHE | 66.75 | - | |
| 201 | Phosphorylation | DVLDDLVTLHNFRNQ HHHHHHHHHHHHHHC | 29.60 | 29083192 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FBX8_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FBX8_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FBX8_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SKP1_HUMAN | SKP1 | physical | 18094045 | |
| CUL1_HUMAN | CUL1 | physical | 18094045 | |
| ARF6_HUMAN | ARF6 | physical | 18094045 | |
| MYC_HUMAN | MYC | physical | 20848231 | |
| MTOR_HUMAN | MTOR | physical | 27916606 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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