COG7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COG7_HUMAN
• UniProt AC: P83436
• Protein Name: Conserved oligomeric Golgi complex subunit 7
• Gene Name: COG7
• Organism: Homo sapiens (Human).
• Sequence Length: 770
• Subcellular Localization: Golgi apparatus membrane ; Peripheral membrane protein .
• Protein Description: Required for normal Golgi function..
• Protein Sequence: MDFSKFLADDFDVKEWINAAFRAGSKEAASGKADGHAATLVMKLQLFIQEVNHAVEETSHQALQNMPKVLRDVEALKQEASFLKEQMILVKEDIKKFEQDTSQSMQVLVEIDQVKSRMQLAAESLQEADKWSTLSADIEETFKTQDIAVISAKLTGMQNSLMMLVDTPDYSEKCVHLEALKNRLEALASPQIVAAFTSQAVDQSKVFVKVFTEIDRMPQLLAYYYKCHKVQLLAAWQELCQSDLSLDRQLTGLYDALLGAWHTQIQWATQVFQKPHEVVMVLLIQTLGALMPSLPSCLSNGVERAGPEQELTRLLEFYDATAHFAKGLEMALLPHLHEHNLVKVTELVDAVYDPYKPYQLKYGDMEESNLLIQMSAVPLEHGEVIDCVQELSHSVNKLFGLASAAVDRCVRFTNGLGTCGLLSALKSLFAKYVSDFTSTLQSIRKKCKLDHIPPNSLFQEDWTAFQNSIRIIATCGELLRHCGDFEQQLANRILSTAGKYLSDSCSPRSLAGFQESILTDKKNSAKNPWQEYNYLQKDNPAEYASLMEILYTLKEKGSSNHNLLAAPRAALTRLNQQAHQLAFDSVFLRIKQQLLLISKMDSWNTAGIGETLTDELPAFSLTPLEYISNIGQYIMSLPLNLEPFVTQEDSALELALHAGKLPFPPEQGDELPELDNMADNWLGSIARATMQTYCDAILQIPELSPHSAKQLATDIDYLINVMDALGLQPSRTLQHIVTLLKTRPEDYRQVSKGLPRRLATTVATMRSVNY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Ubiquitination	SKEAASGKADGHAAT CHHHHCCCCCCHHHH	40.59	-
68	Ubiquitination	QALQNMPKVLRDVEA HHHHCHHHHHHHHHH	43.03	-
77	Ubiquitination	LRDVEALKQEASFLK HHHHHHHHHHHHHHH	53.81	-
81	Phosphorylation	EALKQEASFLKEQMI HHHHHHHHHHHHHHH	30.29	24719451
84	Ubiquitination	KQEASFLKEQMILVK HHHHHHHHHHHHHHH	43.84	-
91	Ubiquitination	KEQMILVKEDIKKFE HHHHHHHHHHHHHHH	46.34	-
91	Acetylation	KEQMILVKEDIKKFE HHHHHHHHHHHHHHH	46.34	23236377
101	Phosphorylation	IKKFEQDTSQSMQVL HHHHHCCCHHHHHHH	28.49	29978859
102	Phosphorylation	KKFEQDTSQSMQVLV HHHHCCCHHHHHHHH	28.66	29978859
104	Phosphorylation	FEQDTSQSMQVLVEI HHCCCHHHHHHHHHH	15.79	29978859
144	Phosphorylation	DIEETFKTQDIAVIS HHHHHHCCCCHHHHH	27.55	28270605
151	Phosphorylation	TQDIAVISAKLTGMQ CCCHHHHHHHHHCCC	16.86	28270605
155	Phosphorylation	AVISAKLTGMQNSLM HHHHHHHHCCCCCEE	29.87	28270605
160	Phosphorylation	KLTGMQNSLMMLVDT HHHCCCCCEEHHHCC	10.76	28270605
167	Phosphorylation	SLMMLVDTPDYSEKC CEEHHHCCCCHHHHH	15.58	28270605
170	Phosphorylation	MLVDTPDYSEKCVHL HHHCCCCHHHHHHHH	21.67	28270605
171	Phosphorylation	LVDTPDYSEKCVHLE HHCCCCHHHHHHHHH	37.65	28270605
181	Ubiquitination	CVHLEALKNRLEALA HHHHHHHHHHHHHHH	47.25	-
189	Phosphorylation	NRLEALASPQIVAAF HHHHHHHCHHHHHHH	20.42	-
212	Phosphorylation	KVFVKVFTEIDRMPQ HHHHHHHHHHHCHHH	34.71	30576142
223	Phosphorylation	RMPQLLAYYYKCHKV CHHHHHHHHHHHHHH	13.80	30576142
356	Ubiquitination	DAVYDPYKPYQLKYG HHHCCCCCCCCCCCC	42.51	-
403	Phosphorylation	NKLFGLASAAVDRCV HHHHHHHHHHHHHHH	23.08	20071362
413	Phosphorylation	VDRCVRFTNGLGTCG HHHHHHHCCCCCHHH	20.15	-
432	Phosphorylation	LKSLFAKYVSDFTST HHHHHHHHHHHHHHH	11.19	25599653
434	Phosphorylation	SLFAKYVSDFTSTLQ HHHHHHHHHHHHHHH	24.74	28122231
437	Phosphorylation	AKYVSDFTSTLQSIR HHHHHHHHHHHHHHH	26.28	28122231
438	Phosphorylation	KYVSDFTSTLQSIRK HHHHHHHHHHHHHHH	27.41	28122231
439	Phosphorylation	YVSDFTSTLQSIRKK HHHHHHHHHHHHHHH	26.26	28122231
480	Methylation	ATCGELLRHCGDFEQ HHHHHHHHHCCHHHH	35.36	-
499	Ubiquitination	RILSTAGKYLSDSCS HHHHHHHHHHCCCCC	40.32	-
500	Phosphorylation	ILSTAGKYLSDSCSP HHHHHHHHHCCCCCH	15.55	26552605
502	Phosphorylation	STAGKYLSDSCSPRS HHHHHHHCCCCCHHH	25.12	26552605
504	Phosphorylation	AGKYLSDSCSPRSLA HHHHHCCCCCHHHHC	17.08	16964243
506	Phosphorylation	KYLSDSCSPRSLAGF HHHCCCCCHHHHCCH	27.57	25159151
509	Phosphorylation	SDSCSPRSLAGFQES CCCCCHHHHCCHHHH	26.42	20873877
516	Phosphorylation	SLAGFQESILTDKKN HHCCHHHHHHCCCCC	16.47	28555341
516	O-linked_Glycosylation	SLAGFQESILTDKKN HHCCHHHHHHCCCCC	16.47	30059200
519	Phosphorylation	GFQESILTDKKNSAK CHHHHHHCCCCCCCC	44.07	28555341
521	Ubiquitination	QESILTDKKNSAKNP HHHHHCCCCCCCCCC	48.93	21906983
522	Ubiquitination	ESILTDKKNSAKNPW HHHHCCCCCCCCCCH	59.97	-
526	Ubiquitination	TDKKNSAKNPWQEYN CCCCCCCCCCHHHHH	64.46	-
585	Phosphorylation	AHQLAFDSVFLRIKQ HHHHHHHHHHHHHHH	14.33	20068231
713	Phosphorylation	HSAKQLATDIDYLIN HCHHHHHHHHHHHHH	41.92	25332170
717	Phosphorylation	QLATDIDYLINVMDA HHHHHHHHHHHHHHH	15.15	25332170
732	Phosphorylation	LGLQPSRTLQHIVTL CCCCCCHHHHHHHHH	34.80	27499020
738	Phosphorylation	RTLQHIVTLLKTRPE HHHHHHHHHHHHCHH	26.27	27499020
742	Phosphorylation	HIVTLLKTRPEDYRQ HHHHHHHHCHHHHHH	51.96	24719451
751	Phosphorylation	PEDYRQVSKGLPRRL HHHHHHHHCCCCHHH	16.81	-
752	Ubiquitination	EDYRQVSKGLPRRLA HHHHHHHCCCCHHHH	66.66	-
760	Phosphorylation	GLPRRLATTVATMRS CCCHHHHHHHHHHHC	26.79	28857561
764	Phosphorylation	RLATTVATMRSVNY- HHHHHHHHHHCCCC-	14.58	25690035

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COG7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COG7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COG7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COG5_HUMAN	COG5	physical	15047703
COG4_HUMAN	COG4	physical	15047703
COG8_HUMAN	COG8	physical	22939629
COG3_HUMAN	COG3	physical	22863883
COG5_HUMAN	COG5	physical	22863883
K2C7_HUMAN	KRT7	physical	22863883
MAP4_HUMAN	MAP4	physical	22863883

Drug and Disease Associations

• Kegg Disease
• H00119: Congenital disorders of glycosylation (CDG) type II
• OMIM Disease
• 608779: Congenital disorder of glycosylation 2E (CDG2E)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.