| UniProt ID | SYT9_HUMAN | |
|---|---|---|
| UniProt AC | Q86SS6 | |
| Protein Name | Synaptotagmin-9 | |
| Gene Name | SYT9 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 491 | |
| Subcellular Localization |
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Single-pass membrane protein. |
|
| Protein Description | May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.. | |
| Protein Sequence | MPGARDALCHQALQLLAELCARGALEHDSCQDFIYHLRDRARPRLRDPDISVSLLTLVVTACGLALFGVSLFVSWKLCWVPWRERGLPSGSKDNNQEPLNYMDTETNEQENSEDFLDPPTPCPDSSMKISHTSPDIPLSTQTGIQENCAHGVRVQRQVTEPTSSARHNSIRRQLNLSNPDFNIQQLQKQEQLTGIGRIKPELYKQRSLDNDDGRRSNSKACGKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIYLLPDRKTKHQTKVHRKTLNPVFDEVFLFPVPYNDLEARKLHFSVYDFDRFSRHDLIGQVVVDHFLDLADFPRECILWKDIEYVTNDNVDLGELMFSLCYLPTAGRLTITIIKARNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTKRNTLNPVYNEAIVFDVPPENIDQIHLSIAVMDYDRVGHNEIIGVCQVGNEAERLGRDHWSEMLSYPRKPIAHWHSLVEKR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 51 | Phosphorylation | RLRDPDISVSLLTLV CCCCCCCCHHHHHHH | 17.03 | 22468782 | |
| 53 | Phosphorylation | RDPDISVSLLTLVVT CCCCCCHHHHHHHHH | 15.75 | 22468782 | |
| 74 | Phosphorylation | FGVSLFVSWKLCWVP HHHHHHHEEEEECCC | 15.91 | 22468782 | |
| 130 | Phosphorylation | PDSSMKISHTSPDIP CCCCCCCCCCCCCCC | 18.39 | 27251275 | |
| 132 | Phosphorylation | SSMKISHTSPDIPLS CCCCCCCCCCCCCCC | 34.85 | 27251275 | |
| 133 | Phosphorylation | SMKISHTSPDIPLST CCCCCCCCCCCCCCC | 18.36 | 27251275 | |
| 169 | Phosphorylation | TSSARHNSIRRQLNL CCHHHHHHHHHHHCC | 16.02 | 22468782 | |
| 177 | Phosphorylation | IRRQLNLSNPDFNIQ HHHHHCCCCCCCCHH | 45.29 | 24719451 | |
| 207 | Phosphorylation | PELYKQRSLDNDDGR HHHHHCCCCCCCCCC | 37.27 | 24719451 | |
| 269 | Ubiquitination | IYLLPDRKTKHQTKV EEECCCCCCCCCCCC | 70.11 | - | |
| 271 | Ubiquitination | LLPDRKTKHQTKVHR ECCCCCCCCCCCCCH | 36.43 | 30230243 | |
| 275 | Ubiquitination | RKTKHQTKVHRKTLN CCCCCCCCCCHHHCC | 29.49 | - | |
| 306 | Phosphorylation | EARKLHFSVYDFDRF HHHCCCEEEECCCCC | 14.71 | 24076635 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SYT9_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SYT9_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SYT9_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TBB5_HUMAN | TUBB | physical | 12966166 | |
| HNRPQ_HUMAN | SYNCRIP | physical | 10734137 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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