PLP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLP2_HUMAN
• UniProt AC: Q04941
• Protein Name: Proteolipid protein 2
• Gene Name: PLP2
• Organism: Homo sapiens (Human).
• Sequence Length: 152
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: May play a role in cell differentiation in the intestinal epithelium..
• Protein Sequence: MADSERLSAPGCWAACTNFSRTRKGILLFAEIILCLVILICFSASTPGYSSLSVIEMILAAIFFVVYMCDLHTKIPFINWPWSDFFRTLIAAILYLITSIVVLVERGNHSKIVAGVLGLIATCLFGYDAYVTFPVRQPRHTAAPTDPADGPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MADSERLSAPG ----CCCHHCCCCCC	18.32	25159151
8	Phosphorylation	MADSERLSAPGCWAA CCCHHCCCCCCHHHH	38.34	25159151
12	S-palmitoylation	ERLSAPGCWAACTNF HCCCCCCHHHHHCCC	1.86	29575903
16	S-palmitoylation	APGCWAACTNFSRTR CCCHHHHHCCCCHHH	2.17	29575903
18	N-linked_Glycosylation	GCWAACTNFSRTRKG CHHHHHCCCCHHHHH	32.55	UniProtKB CARBOHYD
108	N-linked_Glycosylation	VVLVERGNHSKIVAG HHHHHCCCCHHHHHH	42.34	UniProtKB CARBOHYD
141	Phosphorylation	PVRQPRHTAAPTDPA CCCCCCCCCCCCCCC	26.29	23312004
141	O-linked_Glycosylation	PVRQPRHTAAPTDPA CCCCCCCCCCCCCCC	26.29	46266417
145	Phosphorylation	PRHTAAPTDPADGPV CCCCCCCCCCCCCCC	50.30	28985074
145	O-linked_Glycosylation	PRHTAAPTDPADGPV CCCCCCCCCCCCCCC	50.30	62162039

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELP1_HUMAN	IKBKAP	physical	16169070
PLP2_HUMAN	PLP2	physical	9124532
SFXN3_HUMAN	SFXN3	physical	22939629
S10AB_HUMAN	S100A11	physical	22939629
PTCD3_HUMAN	PTCD3	physical	22939629
PYRD_HUMAN	DHODH	physical	22939629
STT3B_HUMAN	STT3B	physical	22939629
S12A4_HUMAN	SLC12A4	physical	22939629
RM30_HUMAN	MRPL30	physical	22939629
RT63_HUMAN	MRPL57	physical	22939629
RM09_HUMAN	MRPL9	physical	22939629
RM41_HUMAN	MRPL41	physical	22939629
TMM79_HUMAN	TMEM79	physical	25416956
KASH5_HUMAN	CCDC155	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.