| UniProt ID | FBH1_HUMAN | |
|---|---|---|
| UniProt AC | Q8NFZ0 | |
| Protein Name | F-box DNA helicase 1 {ECO:0000303|PubMed:11956208} | |
| Gene Name | FBH1 {ECO:0000312|HGNC:HGNC:13620} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1043 | |
| Subcellular Localization | Nucleus . Chromosome . Accumulates at sites of DNA damage or replication stress (PubMed:19736316, PubMed:23677613). PCNA is required for localization to DNA damage sites (PubMed:23677613). Localizes to the nucleoplasm in absence of DNA damage (PubMed | |
| Protein Description | 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. [PubMed: 11956208] | |
| Protein Sequence | MRRFKRKHLTAIDCQHLARSHLAVTQPFGQRWTNRDPNHGLYPKPRTKRGSRGQGSQRCIPEFFLAGKQPCTNDMAKSNSVGQDSCQDSEGDMIFPAESSCALPQEGSAGPGSPGSAPPSRKRSWSSEEESNQATGTSRWDGVSKKAPRHHLSVPCTRPREARQEAEDSTSRLSAESGETDQDAGDVGPDPIPDSYYGLLGTLPCQEALSHICSLPSEVLRHVFAFLPVEDLYWNLSLVCHLWREIISDPLFIPWKKLYHRYLMNEEQAVSKVDGILSNCGIEKESDLCVLNLIRYTATTKCSPSVDPERVLWSLRDHPLLPEAEACVRQHLPDLYAAAGGVNIWALVAAVVLLSSSVNDIQRLLFCLRRPSSTVTMPDVTETLYCIAVLLYAMREKGINISNRIHYNIFYCLYLQENSCTQATKVKEEPSVWPGKKTIQLTHEQQLILNHKMEPLQVVKIMAFAGTGKTSTLVKYAEKWSQSRFLYVTFNKSIAKQAERVFPSNVICKTFHSMAYGHIGRKYQSKKKLNLFKLTPFMVNSVLAEGKGGFIRAKLVCKTLENFFASADEELTIDHVPIWCKNSQGQRVMVEQSEKLNGVLEASRLWDNMRKLGECTEEAHQMTHDGYLKLWQLSKPSLASFDAIFVDEAQDCTPAIMNIVLSQPCGKIFVGDPHQQIYTFRGAVNALFTVPHTHVFYLTQSFRFGVEIAYVGATILDVCKRVRKKTLVGGNHQSGIRGDAKGQVALLSRTNANVFDEAVRVTEGEFPSRIHLIGGIKSFGLDRIIDIWILLQPEEERRKQNLVIKDKFIRRWVHKEGFSGFKRYVTAAEDKELEAKIAVVEKYNIRIPELVQRIEKCHIEDLDFAEYILGTVHKAKGLEFDTVHVLDDFVKVPCARHNLPQLPHFRVESFSEDEWNLLYVAVTRAKKRLIMTKSLENILTLAGEYFLQAELTSNVLKTGVVRCCVGQCNNAIPVDTVLTMKKLPITYSNRKENKGGYLCHSCAEQRIGPLAFLTASPEQVRAMERTVENIVLPRHEALLFLVF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 20 | Phosphorylation | DCQHLARSHLAVTQP HHHHHHHHHCEEECC | 27251275 | ||
| 25 | Phosphorylation | ARSHLAVTQPFGQRW HHHHCEEECCCCCCC | 27251275 | ||
| 71 | Phosphorylation | FLAGKQPCTNDMAKS HHCCCCCCCCHHHHC | 27251275 | ||
| 72 | Phosphorylation | LAGKQPCTNDMAKSN HCCCCCCCCHHHHCC | 22210691 | ||
| 78 | Phosphorylation | CTNDMAKSNSVGQDS CCCHHHHCCCCCCCC | 22210691 | ||
| 113 | Phosphorylation | EGSAGPGSPGSAPPS CCCCCCCCCCCCCCC | 28348404 | ||
| 116 | Phosphorylation | AGPGSPGSAPPSRKR CCCCCCCCCCCCCCC | 22210691 | ||
| 124 | Phosphorylation | APPSRKRSWSSEEES CCCCCCCCCCCHHHH | 23927012 | ||
| 126 | Phosphorylation | PSRKRSWSSEEESNQ CCCCCCCCCHHHHHC | 23927012 | ||
| 127 | Phosphorylation | SRKRSWSSEEESNQA CCCCCCCCHHHHHCC | 23927012 | ||
| 131 | Phosphorylation | SWSSEEESNQATGTS CCCCHHHHHCCCCCC | 23403867 | ||
| 135 | Phosphorylation | EEESNQATGTSRWDG HHHHHCCCCCCCCCC | 23403867 | ||
| 153 | Phosphorylation | KAPRHHLSVPCTRPR CCCCCCCCCCCCCHH | 27251275 | ||
| 164 | Phosphorylation | TRPREARQEAEDSTS CCHHHHHHHHHHHCC | 27251275 | ||
| 175 | Phosphorylation | DSTSRLSAESGETDQ HHCCCHHHCCCCCCC | 27251275 | ||
| 177 | Phosphorylation | TSRLSAESGETDQDA CCCHHHCCCCCCCCC | 24719451 | ||
| 178 | Phosphorylation | SRLSAESGETDQDAG CCHHHCCCCCCCCCC | 27251275 | ||
| 204 | Phosphorylation | YGLLGTLPCQEALSH HHHHCCCCHHHHHHH | 27251275 | ||
| 257 | Ubiquitination | PLFIPWKKLYHRYLM CCCCCHHHHHHHHHC | - | ||
| 271 | Phosphorylation | MNEEQAVSKVDGILS CCHHHHHHHHCHHHH | 23532336 | ||
| 272 | Ubiquitination | NEEQAVSKVDGILSN CHHHHHHHHCHHHHH | - | ||
| 301 | Ubiquitination | IRYTATTKCSPSVDP HHHHHCCCCCCCCCH | - | ||
| 308 (in isoform 2) | Ubiquitination | - | - | ||
| 314 | Phosphorylation | DPERVLWSLRDHPLL CHHHHHHHHHCCCCC | 24719451 | ||
| 352 (in isoform 2) | Ubiquitination | - | - | ||
| 383 | Phosphorylation | TMPDVTETLYCIAVL CCCCHHHHHHHHHHH | 22210691 | ||
| 392 | Phosphorylation | YCIAVLLYAMREKGI HHHHHHHHHHHHCCC | 22210691 | ||
| 427 | Acetylation | CTQATKVKEEPSVWP CCCCCCCCCCCCCCC | 25953088 | ||
| 469 | Ubiquitination | MAFAGTGKTSTLVKY EEECCCCCHHHHHHH | - | ||
| 475 | Ubiquitination | GKTSTLVKYAEKWSQ CCHHHHHHHHHHHCC | - | ||
| 479 | Ubiquitination | TLVKYAEKWSQSRFL HHHHHHHHHCCCCEE | - | ||
| 547 | Ubiquitination | NSVLAEGKGGFIRAK HHHHHCCCCCHHHHH | - | ||
| 598 (in isoform 2) | Ubiquitination | - | - | ||
| 611 | Ubiquitination | RLWDNMRKLGECTEE HHHHHHHHHCCCCHH | - | ||
| 629 | Ubiquitination | MTHDGYLKLWQLSKP HCCCCHHHHHHCCCC | - | ||
| 662 (in isoform 2) | Ubiquitination | - | - | ||
| 725 | Ubiquitination | VCKRVRKKTLVGGNH HHHHHHHCCCCCCCC | - | ||
| 726 | Phosphorylation | CKRVRKKTLVGGNHQ HHHHHHCCCCCCCCC | - | ||
| 741 | Ubiquitination | SGIRGDAKGQVALLS CCCCCCCHHHEEEEE | - | ||
| 777 | Ubiquitination | IHLIGGIKSFGLDRI EEEECCHHHCCCCCE | - | ||
| 822 | Ubiquitination | KEGFSGFKRYVTAAE HHCCCCHHHEEHHHH | - | ||
| 828 (in isoform 2) | Ubiquitination | - | - | ||
| 836 | Ubiquitination | EDKELEAKIAVVEKY HHHHHHHHEEEEEHH | - | ||
| 842 | Ubiquitination | AKIAVVEKYNIRIPE HHEEEEEHHCCCHHH | - | ||
| 856 | Ubiquitination | ELVQRIEKCHIEDLD HHHHHHHHCCCCCCC | - | ||
| 876 | Ubiquitination | LGTVHKAKGLEFDTV HHHHHHHCCCCCEEE | - | ||
| 891 | Ubiquitination | HVLDDFVKVPCARHN EECCCCCCCCCHHCC | - | ||
| 893 (in isoform 2) | Ubiquitination | - | - | ||
| 927 (in isoform 2) | Ubiquitination | - | - | ||
| 942 (in isoform 2) | Ubiquitination | - | - | ||
| 982 | Ubiquitination | DTVLTMKKLPITYSN CCEEEEEECCCEECC | - | ||
| 994 | Ubiquitination | YSNRKENKGGYLCHS ECCCCCCCCCEECCC | - | ||
| 1042 (in isoform 2) | Ubiquitination | - | - | ||
| 1045 (in isoform 2) | Ubiquitination | - | - |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FBH1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FBH1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SKP1_HUMAN | SKP1 | physical | 11956208 | |
| CUL1_HUMAN | CUL1 | physical | 11956208 | |
| CUL1_HUMAN | CUL1 | physical | 15118074 | |
| SKP1_HUMAN | SKP1 | physical | 15118074 | |
| RBX1_HUMAN | RBX1 | physical | 15118074 | |
| RAD51_HUMAN | RAD51 | physical | 23393192 | |
| RFA1_HUMAN | RPA1 | physical | 23319600 | |
| RFA2_HUMAN | RPA2 | physical | 23319600 | |
| RFA3_HUMAN | RPA3 | physical | 23319600 | |
| SKP1_HUMAN | SKP1 | physical | 23319600 | |
| CUL1_HUMAN | CUL1 | physical | 23319600 | |
| RAD51_HUMAN | RAD51 | physical | 24108124 | |
| PCNA_HUMAN | PCNA | physical | 23677613 | |
| PRR3_HUMAN | PRR3 | physical | 26496610 | |
| ILKAP_HUMAN | ILKAP | physical | 26496610 | |
| RRFM_HUMAN | MRRF | physical | 26496610 | |
| RAD51_HUMAN | RAD51 | physical | 25585578 | |
| UBC_HUMAN | UBC | physical | 24667174 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
