SCMC2_HUMAN - dbPTM
SCMC2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SCMC2_HUMAN
UniProt AC Q6KCM7
Protein Name Calcium-binding mitochondrial carrier protein SCaMC-2
Gene Name SLC25A25
Organism Homo sapiens (Human).
Sequence Length 469
Subcellular Localization Mitochondrion inner membrane
Multi-pass membrane protein .
Protein Description Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria..
Protein Sequence MLCLCLYVPVIGEAQTEFQYFESKGLPAELKSIFKLSVFIPSQEFSTYRQWKQKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGVKISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQSR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3 (in isoform 2)Phosphorylation-2.1423663014
3 (in isoform 3)Phosphorylation-2.1423663014
4 (in isoform 2)Phosphorylation-1.6623663014
4 (in isoform 3)Phosphorylation-1.6623663014
7Phosphorylation-MLCLCLYVPVIGEA
-CEEEEEECCCCCCC		11.17-
10UbiquitinationCLCLYVPVIGEAQTE
EEEEECCCCCCCHHH		6.6523503661
10 (in isoform 6)Ubiquitination-6.6521906983
11 (in isoform 4)Phosphorylation-3.19-
11 (in isoform 5)Phosphorylation-3.19-
18 (in isoform 6)Ubiquitination-8.9521906983
20PhosphorylationEAQTEFQYFESKGLP
CCHHHHHHHHHCCCC		18.03-
32PhosphorylationGLPAELKSIFKLSVF
CCCHHHHHHHEEEEE		45.9724719451
42PhosphorylationKLSVFIPSQEFSTYR
EEEEEECCCHHHHHH		37.21-
46PhosphorylationFIPSQEFSTYRQWKQ
EECCCHHHHHHHHHH		24.63-
47PhosphorylationIPSQEFSTYRQWKQK
ECCCHHHHHHHHHHH		28.22-
48PhosphorylationPSQEFSTYRQWKQKI
CCCHHHHHHHHHHHH		10.29-
54UbiquitinationTYRQWKQKIVQAGDK
HHHHHHHHHHHCCCC		40.9129967540
61UbiquitinationKIVQAGDKDLDGQLD
HHHHCCCCCCCCCCC		60.3129967540
81UbiquitinationHYLQDHEKKLRLVFK
HHHHHHHHHHHHHHH		54.4029967540
92UbiquitinationLVFKSLDKKNDGRID
HHHHHCCCCCCCCCC		59.7924816145
101UbiquitinationNDGRIDAQEIMQSLR
CCCCCCHHHHHHHHH		36.6829967540
112UbiquitinationQSLRDLGVKISEQQA
HHHHHHCCCCCHHHH		6.9124816145
113UbiquitinationSLRDLGVKISEQQAE
HHHHHCCCCCHHHHH		38.4221906983
113 (in isoform 1)Ubiquitination-38.4221906983
115UbiquitinationRDLGVKISEQQAEKI
HHHCCCCCHHHHHHH		24.5129967540
121UbiquitinationISEQQAEKILKSMDK
CCHHHHHHHHHHCCC		57.2521906983
121 (in isoform 1)Ubiquitination-57.2521906983
126UbiquitinationAEKILKSMDKNGTMT
HHHHHHHCCCCCCEE		8.9824816145
133UbiquitinationMDKNGTMTIDWNEWR
CCCCCCEEEEHHHHC		18.6723503661
133 (in isoform 4)Ubiquitination-18.6721906983
133 (in isoform 5)Ubiquitination-18.6721906983
141UbiquitinationIDWNEWRDYHLLHPV
EEHHHHCEEECCCCC		35.9629967540
141 (in isoform 4)Ubiquitination-35.9621906983
141 (in isoform 5)Ubiquitination-35.9621906983
147UbiquitinationRDYHLLHPVENIPEI
CEEECCCCCCCCCHH		34.7823503661
147 (in isoform 2)Ubiquitination-34.7821906983
147 (in isoform 3)Ubiquitination-34.7821906983
148 (in isoform 5)Phosphorylation-6.4828387310
149UbiquitinationYHLLHPVENIPEIIL
EECCCCCCCCCHHHE		54.6227667366
149 (in isoform 6)Ubiquitination-54.6221906983
155UbiquitinationVENIPEIILYWKHST
CCCCCHHHEEEECCC		1.9929967540
155 (in isoform 3)Ubiquitination-1.9921906983
155 (in isoform 2)Ubiquitination-1.9921906983
161UbiquitinationIILYWKHSTIFDVGE
HHEEEECCCCEECCC		21.3327667366
162 (in isoform 3)Phosphorylation-25.9428387310
165UbiquitinationWKHSTIFDVGENLTV
EECCCCEECCCCCCC		43.6023503661
165 (in isoform 5)Phosphorylation-43.6028387310
165 (in isoform 6)Ubiquitination-43.6021906983
177UbiquitinationLTVPDEFTVEERQTG
CCCCCCCEEEEHHHC		25.5923503661
179 (in isoform 3)Phosphorylation-44.3928387310
200PhosphorylationGGGAGAVSRTCTAPL
CCCCCHHHCCCCCCH		22.7223532336
202UbiquitinationGAGAVSRTCTAPLDR
CCCHHHCCCCCCHHH		13.5023503661
202 (in isoform 6)Ubiquitination-13.5021906983
214UbiquitinationLDRLKVLMQVHASRS
HHHHHHHHHHHHHCC		4.3523503661
241PhosphorylationIREGGARSLWRGNGI
HHHCCCCCCCCCCCC		31.5824719451
252UbiquitinationGNGINVLKIAPESAI
CCCCCEEEECCHHHH		32.3227667366
252 (in isoform 1)Ubiquitination-32.3221906983
257PhosphorylationVLKIAPESAIKFMAY
EEEECCHHHHHHHHH		33.95-
260UbiquitinationIAPESAIKFMAYEQI
ECCHHHHHHHHHHHH		28.89-
264PhosphorylationSAIKFMAYEQIKRLV
HHHHHHHHHHHHHHH		9.14-
264UbiquitinationSAIKFMAYEQIKRLV
HHHHHHHHHHHHHHH		9.1427667366
268UbiquitinationFMAYEQIKRLVGSDQ
HHHHHHHHHHHCCCH		39.1023503661
268 (in isoform 1)Ubiquitination-39.1021906983
272UbiquitinationEQIKRLVGSDQETLR
HHHHHHHCCCHHHHH		30.0527667366
272 (in isoform 4)Ubiquitination-30.0521906983
280UbiquitinationSDQETLRIHERLVAG
CCHHHHHHHHHHHHH		4.4423503661
284UbiquitinationTLRIHERLVAGSLAG
HHHHHHHHHHHHHHH		2.5627667366
284 (in isoform 5)Ubiquitination-2.5621906983
286UbiquitinationRIHERLVAGSLAGAI
HHHHHHHHHHHHHHH		13.3727667366
286 (in isoform 2)Ubiquitination-13.3721906983
288UbiquitinationHERLVAGSLAGAIAQ
HHHHHHHHHHHHHHH		12.8123503661
288 (in isoform 4)Ubiquitination-12.8121906983
298UbiquitinationGAIAQSSIYPMEVLK
HHHHHCCCCCHHHHH		5.6127667366
298 (in isoform 3)Ubiquitination-5.6121906983
300UbiquitinationIAQSSIYPMEVLKTR
HHHCCCCCHHHHHHH		15.7023503661
300 (in isoform 5)Ubiquitination-15.7021906983
302UbiquitinationQSSIYPMEVLKTRMA
HCCCCCHHHHHHHHH		39.9523503661
302 (in isoform 2)Ubiquitination-39.9521906983
305UbiquitinationIYPMEVLKTRMALRK
CCCHHHHHHHHHHHH		38.982190698
305 (in isoform 1)Ubiquitination-38.9821906983
312UbiquitinationKTRMALRKTGQYSGM
HHHHHHHHHCCCCCH		58.83-
313PhosphorylationTRMALRKTGQYSGML
HHHHHHHHCCCCCHH		24.08-
314UbiquitinationRMALRKTGQYSGMLD
HHHHHHHCCCCCHHH		27.7123503661
314 (in isoform 3)Ubiquitination-27.7121906983
316PhosphorylationALRKTGQYSGMLDCA
HHHHHCCCCCHHHHH		14.45-
317PhosphorylationLRKTGQYSGMLDCAR
HHHHCCCCCHHHHHH		15.16-
317UbiquitinationLRKTGQYSGMLDCAR
HHHHCCCCCHHHHHH		15.1623503661
325UbiquitinationGMLDCARRILAREGV
CHHHHHHHHHHHHCH		15.1123503661
325 (in isoform 4)Ubiquitination-15.1121906983
337UbiquitinationEGVAAFYKGYVPNML
HCHHHHHCCCCCCCC		36.9923503661
337 (in isoform 5)Ubiquitination-36.9921906983
339UbiquitinationVAAFYKGYVPNMLGI
HHHHHCCCCCCCCCC		14.4723503661
339 (in isoform 2)Ubiquitination-14.4721906983
351UbiquitinationLGIIPYAGIDLAVYE
CCCCCCCCCCHHHHH		14.2223503661
351 (in isoform 3)Ubiquitination-14.2221906983
358 (in isoform 3)Ubiquitination-40.85-
372PhosphorylationLQHYAVNSADPGVFV
HHHHHCCCCCCCEEE		27.7022210691
395PhosphorylationSTCGQLASYPLALVR
CCHHHHHCHHHHHHH		35.5622210691
396PhosphorylationTCGQLASYPLALVRT
CHHHHHCHHHHHHHH		9.1722210691
421PhosphorylationAPEVTMSSLFKHILR
CCCCCHHHHHHHHHH		27.3124719451
429PhosphorylationLFKHILRTEGAFGLY
HHHHHHHHCCCHHHH		35.01-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SCMC2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SCMC2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SCMC2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SCMC3_HUMANSLC25A23physical
28514442
MAP2_HUMANMETAP2physical
28514442
ST38L_HUMANSTK38Lphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SCMC2_HUMAN

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Related Literatures of Post-Translational Modification

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