SYT8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYT8_HUMAN
• UniProt AC: Q8NBV8
• Protein Name: Synaptotagmin-8
• Gene Name: SYT8
• Organism: Homo sapiens (Human).
• Sequence Length: 401
• Subcellular Localization: Cell membrane; Single-pass type III membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome.
• Protein Description: Isoform 4 may play a role in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells (By similarity)..
• Protein Sequence: MLHLHGWQTMQGRKMGHPPVSPSAPAPAGTTAIPGLIPDLVAGTPWPRWALIAGALAAGVLLVSCLLCAACCCCRRHRKKPRDKESVGLGSARGTTTTHLVQPDVDGLESSPGDAQQWGCLQLSLEFDFGSQEIRVGLRQAADLRPGGTVDPYARVSVSTQAGHRHETKVHRGTLCPVFDETCCFHIPQAELPGATLQVQLFNFKRFSGHEPLGELRLPLGTVDLQHVLEHWYLLGPPAATQPEQVGELCFSLRYVPSSGRLTVVVLEARGLRPGLAEPYVKVQLMLNQRKWKKRKTATKKGTAAPYFNEAFTFLVPFSQVQNVDLVLAVWDRSLPLRTEPVGKVHLGARASGQPLQHWADMLAHARRPIAQRHPLRPAREVDRMLALQPRLRLRLPLPHS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	LHLHGWQTMQGRKMG CCCCCCCCCCCCCCC	12.64	24043423
86	Phosphorylation	KKPRDKESVGLGSAR CCCCCCCCCCCCCCC	27.50	22964224
91	Phosphorylation	KESVGLGSARGTTTT CCCCCCCCCCCCCEE	21.60	22964224
153	Phosphorylation	PGGTVDPYARVSVST CCCCCCCCCEEEEEC	11.54	-
255	Phosphorylation	ELCFSLRYVPSSGRL HHEEEEEECCCCCEE	23.23	24719451
258	Phosphorylation	FSLRYVPSSGRLTVV EEEEECCCCCEEEEE	35.07	28348404
259	Phosphorylation	SLRYVPSSGRLTVVV EEEECCCCCEEEEEE	23.12	28348404
263	Phosphorylation	VPSSGRLTVVVLEAR CCCCCEEEEEEEEEC	15.19	24719451
334	Phosphorylation	VLAVWDRSLPLRTEP EEEEECCCCCCCCCC	31.69	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYT8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYT8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYT8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HNRPQ_HUMAN	SYNCRIP	physical	10734137

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.