Z286A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: Z286A_HUMAN
• UniProt AC: Q9HBT8
• Protein Name: Zinc finger protein 286A
• Gene Name: ZNF286A
• Organism: Homo sapiens (Human).
• Sequence Length: 521
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: METDLAEMPEKGALSSQDSPHFQEKSTEEGEVAALRLTARSQETVTFKDVAMDFTPEEWGKLDPAQRDVMLENYRNLVSLWLPVSKPESYNLENGKEPLKLERKAPKSSYSDMETRPQSKDSTSVQDFSKAESCKVAIIDRLTRNSVYDSNLEAALECENWLENQQGNQERHLREMFTHMNSLSEETDHKHDVYWKSFNQKSVLITEDRVPKGSYAFHTLEKSLKQKSNLMKKQRTYKEKKPHKCNDCGELFTYHSVLIRHQRVHTGEKPYTCNECGKSFSHRANLTKHQRTHTRILFECSECKKTFTESSSLATHQRIHVGERPYECNECGKGFNRSTHLVQHQLIHTGVKPYECNECDKAFIHSSALIKHQRTHTGEKPYKCQECGKAFSHCSSLTKHQRVHTGEKPYECSECGKTFSQSTHLVQHQRIHTGEKPYECNECGKTFSRSSNFAKHQRIHIGKKPYKCSECGKAFIHSSALIQHQRTHTGEKPFRCNECGKSFKCSSSLIRHQRVHTEEQP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----METDLAEMPE -----CCCCHHHCCC	34.71	-
9 (in isoform 2)	Phosphorylation	-	31.49	25849741
15	Phosphorylation	MPEKGALSSQDSPHF CCCCCCCCCCCCCCC	25.97	30266825
16	Phosphorylation	PEKGALSSQDSPHFQ CCCCCCCCCCCCCCC	38.57	30266825
19	Phosphorylation	GALSSQDSPHFQEKS CCCCCCCCCCCCCCC	16.79	30266825
41	Phosphorylation	ALRLTARSQETVTFK EEEEEECCCCEEEEE	29.88	27499020
55	Phosphorylation	KDVAMDFTPEEWGKL EEEECCCCHHHHCCC	26.06	19835603
74	Phosphorylation	RDVMLENYRNLVSLW HHHHHHHHHHHHHHE	7.48	19835603
129	Phosphorylation	STSVQDFSKAESCKV CCCHHHHHHHHCCCE	38.97	29759185
178	Phosphorylation	RHLREMFTHMNSLSE HHHHHHHHHHHCCCC	20.93	22210691
182	Phosphorylation	EMFTHMNSLSEETDH HHHHHHHCCCCCCCC	26.20	22210691
184	Phosphorylation	FTHMNSLSEETDHKH HHHHHCCCCCCCCCC	32.96	22210691
214	Phosphorylation	EDRVPKGSYAFHTLE CCCCCCCHHHHHHHH	21.29	-
215	Phosphorylation	DRVPKGSYAFHTLEK CCCCCCHHHHHHHHH	23.19	-
266	Phosphorylation	IRHQRVHTGEKPYTC EEECCCCCCCCCEEC	44.15	-
305	Ubiquitination	FECSECKKTFTESSS EECHHHCCEECCCCC	61.60	-
375	Phosphorylation	ALIKHQRTHTGEKPY HHHHCCCCCCCCCCE	19.74	28348404
377	Phosphorylation	IKHQRTHTGEKPYKC HHCCCCCCCCCCEEH	46.56	26270265
380	Ubiquitination	QRTHTGEKPYKCQEC CCCCCCCCCEEHHHC	55.80	-
392	Phosphorylation	QECGKAFSHCSSLTK HHCHHHHHCHHHCCC	28.57	25002506
395	Phosphorylation	GKAFSHCSSLTKHQR HHHHHCHHHCCCCCC	23.98	25002506
396	Phosphorylation	KAFSHCSSLTKHQRV HHHHCHHHCCCCCCC	45.51	25002506
398	Phosphorylation	FSHCSSLTKHQRVHT HHCHHHCCCCCCCCC	28.55	25002506
405	Phosphorylation	TKHQRVHTGEKPYEC CCCCCCCCCCCCEEC	44.15	28348404
413	Phosphorylation	GEKPYECSECGKTFS CCCCEECCCCCCEEC	24.79	-
426	Ubiquitination	FSQSTHLVQHQRIHT ECCCCCCEECCEECC	3.56	-
433	Phosphorylation	VQHQRIHTGEKPYEC EECCEECCCCCCEEC	44.67	28152594
435	Ubiquitination	HQRIHTGEKPYECNE CCEECCCCCCEECCC	52.60	-
436	Ubiquitination	QRIHTGEKPYECNEC CEECCCCCCEECCCC	55.00	-
438	Phosphorylation	IHTGEKPYECNECGK ECCCCCCEECCCCCC	44.15	28152594
445	Ubiquitination	YECNECGKTFSRSSN EECCCCCCEECCCCC	59.04	-
487	Phosphorylation	ALIQHQRTHTGEKPF HHHHCCCCCCCCCCE	19.74	-
489	Phosphorylation	IQHQRTHTGEKPFRC HHCCCCCCCCCCEEC	46.56	29496963
492	Ubiquitination	QRTHTGEKPFRCNEC CCCCCCCCCEECCCC	51.29	-
507	Phosphorylation	GKSFKCSSSLIRHQR CCEEECCHHHHHHCC	38.34	24719451
508	Phosphorylation	KSFKCSSSLIRHQRV CEEECCHHHHHHCCC	16.12	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of Z286A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of Z286A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of Z286A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
K1C40_HUMAN	KRT40	physical	25416956
KR101_HUMAN	KRTAP10-1	physical	25416956
NEUL4_HUMAN	NEURL4	physical	28514442
HERC2_HUMAN	HERC2	physical	28514442
ZN121_HUMAN	ZNF121	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
ECI2_HUMAN	ECI2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.