HBG2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HBG2_HUMAN
• UniProt AC: P69892
• Protein Name: Hemoglobin subunit gamma-2
• Gene Name: HBG2
• Organism: Homo sapiens (Human).
• Sequence Length: 147
• Protein Description: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains..
• Protein Sequence: MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPKVKAHGKKVLTSLGDAIKHLDDLKGTFAQLSELHCDKLHVDPENFKLLGNVLVTVLAIHFGKEFTPEVQASWQKMVTGVASALSSRYH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MGHFTEEDK ------CCCCCHHHH	25.31	5554303
5	Phosphorylation	---MGHFTEEDKATI ---CCCCCHHHHHHH	32.56	24719451
9	Acetylation	GHFTEEDKATITSLW CCCCHHHHHHHHHHH	51.19	30584561
9	Ubiquitination	GHFTEEDKATITSLW CCCCHHHHHHHHHHH	51.19	-
11	Phosphorylation	FTEEDKATITSLWGK CCHHHHHHHHHHHEE	30.45	23186163
13	Phosphorylation	EEDKATITSLWGKVN HHHHHHHHHHHEEEC	17.26	23186163
14	Phosphorylation	EDKATITSLWGKVNV HHHHHHHHHHEEECH	20.48	23917254
18	Ubiquitination	TITSLWGKVNVEDAG HHHHHHEEECHHHCC	21.03	-
28	Phosphorylation	VEDAGGETLGRLLVV HHHCCCCCCHHHEEE	37.47	28857561
36	Phosphorylation	LGRLLVVYPWTQRFF CHHHEEEECCHHHHH	5.88	24927040
39	Phosphorylation	LLVVYPWTQRFFDSF HEEEECCHHHHHHHC	12.83	28857561
45	Phosphorylation	WTQRFFDSFGNLSSA CHHHHHHHCCCCCCH	29.87	22673903
50	Phosphorylation	FDSFGNLSSASAIMG HHHCCCCCCHHHHCC	28.05	30242111
51	Phosphorylation	DSFGNLSSASAIMGN HHCCCCCCHHHHCCC	29.43	30242111
53	Phosphorylation	FGNLSSASAIMGNPK CCCCCCHHHHCCCCC	21.92	30242111
60	Ubiquitination	SAIMGNPKVKAHGKK HHHCCCCCHHHHHHH	61.44	-
60	Acetylation	SAIMGNPKVKAHGKK HHHCCCCCHHHHHHH	61.44	30584569
62	Ubiquitination	IMGNPKVKAHGKKVL HCCCCCHHHHHHHHH	40.57	-
62	Acetylation	IMGNPKVKAHGKKVL HCCCCCHHHHHHHHH	40.57	7289975
66	Acetylation	PKVKAHGKKVLTSLG CCHHHHHHHHHHHHH	29.82	30584573
66	Ubiquitination	PKVKAHGKKVLTSLG CCHHHHHHHHHHHHH	29.82	-
67	Ubiquitination	KVKAHGKKVLTSLGD CHHHHHHHHHHHHHH	47.25	-
70	Phosphorylation	AHGKKVLTSLGDAIK HHHHHHHHHHHHHHH	25.54	28857561
71	Phosphorylation	HGKKVLTSLGDAIKH HHHHHHHHHHHHHHC	26.62	28857561
77	Ubiquitination	TSLGDAIKHLDDLKG HHHHHHHHCHHHHCC	39.57	-
77	Acetylation	TSLGDAIKHLDDLKG HHHHHHHHCHHHHCC	39.57	30584577
83	Acetylation	IKHLDDLKGTFAQLS HHCHHHHCCHHHHHH	64.00	156877
83	Ubiquitination	IKHLDDLKGTFAQLS HHCHHHHCCHHHHHH	64.00	-
94	S-nitrosylation	AQLSELHCDKLHVDP HHHHHHCCCCCCCCH	8.46	-
96	Ubiquitination	LSELHCDKLHVDPEN HHHHCCCCCCCCHHH	45.98	-
96	Acetylation	LSELHCDKLHVDPEN HHHHCCCCCCCCHHH	45.98	30584565
113	Phosphorylation	LLGNVLVTVLAIHFG HHHHHHHHHHHHHHC	12.97	-
124	Phosphorylation	IHFGKEFTPEVQASW HHHCCCCCHHHHHHH	21.45	30242111
130	Phosphorylation	FTPEVQASWQKMVTG CCHHHHHHHHHHHHH	16.98	28857561
133	Ubiquitination	EVQASWQKMVTGVAS HHHHHHHHHHHHHHH	29.13	-
136	Phosphorylation	ASWQKMVTGVASALS HHHHHHHHHHHHHHH	23.57	30242111
140	Phosphorylation	KMVTGVASALSSRYH HHHHHHHHHHHHCCC	27.60	30242111
143	Phosphorylation	TGVASALSSRYH--- HHHHHHHHHCCC---	16.70	30242111
144	Phosphorylation	GVASALSSRYH---- HHHHHHHHCCC----	37.39	6186522

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HBG2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
2	G	Acetylation	Acetylation of Gly-2 converts Hb F to the minor Hb F1.	5554303

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HBG2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HBG2_HUMAN	HBG2	physical	11514664
A4_HUMAN	APP	physical	21832049
RSSA_HUMAN	RPSA	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613977: Cyanosis transient neonatal (TNCY)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Human fetal hemoglobin F 1. Acetylation status.";
Stegink L.D., Meyer P.D., Brummel M.C.;
J. Biol. Chem. 246:3001-3007(1971).
Cited for: ACETYLATION AT GLY-2.
PubMed: 5554303

Phosphorylation

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-36, AND MASSSPECTROMETRY.
PubMed: 18083107