HBE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HBE_HUMAN
• UniProt AC: P02100
• Protein Name: Hemoglobin subunit epsilon
• Gene Name: HBE1
• Organism: Homo sapiens (Human).
• Sequence Length: 147
• Protein Description: The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin..
• Protein Sequence: MVHFTAEEKAAVTSLWSKMNVEEAGGEALGRLLVVYPWTQRFFDSFGNLSSPSAILGNPKVKAHGKKVLTSFGDAIKNMDNLKPAFAKLSELHCDKLHVDPENFKLLGNVMVIILATHFGKEFTPEVQAAWQKLVSAVAIALAHKYH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	EEKAAVTSLWSKMNV HHHHHHHHHHHHCCH	22.65	23917254
17	Phosphorylation	AAVTSLWSKMNVEEA HHHHHHHHHCCHHHH	27.59	26074081
18	Ubiquitination	AVTSLWSKMNVEEAG HHHHHHHHCCHHHHH	23.94	-
36	Phosphorylation	LGRLLVVYPWTQRFF HHHHEEHHHCHHHHH	5.88	24927040
39	Phosphorylation	LLVVYPWTQRFFDSF HEEHHHCHHHHHHCC	12.83	28857561
45	Phosphorylation	WTQRFFDSFGNLSSP CHHHHHHCCCCCCCH	29.87	23186163
50	Phosphorylation	FDSFGNLSSPSAILG HHCCCCCCCHHHHHC	44.17	22817900
51	Phosphorylation	DSFGNLSSPSAILGN HCCCCCCCHHHHHCC	26.49	23917254
53	Phosphorylation	FGNLSSPSAILGNPK CCCCCCHHHHHCCCC	29.86	23917254
60	Acetylation	SAILGNPKVKAHGKK HHHHCCCCHHHCCEE	61.44	132949
60	Ubiquitination	SAILGNPKVKAHGKK HHHHCCCCHHHCCEE	61.44	-
66	Acetylation	PKVKAHGKKVLTSFG CCHHHCCEEEHHHHH	29.82	30589107
67	Ubiquitination	KVKAHGKKVLTSFGD CHHHCCEEEHHHHHH	47.25	-
70	Phosphorylation	AHGKKVLTSFGDAIK HCCEEEHHHHHHHHH	25.62	21082442
71	Phosphorylation	HGKKVLTSFGDAIKN CCEEEHHHHHHHHHC	24.07	19664995
77	Ubiquitination	TSFGDAIKNMDNLKP HHHHHHHHCHHHCHH	48.19	-
77	Acetylation	TSFGDAIKNMDNLKP HHHHHHHHCHHHCHH	48.19	30589113
83	Acetylation	IKNMDNLKPAFAKLS HHCHHHCHHHHHHHH	40.32	30589101
83	Ubiquitination	IKNMDNLKPAFAKLS HHCHHHCHHHHHHHH	40.32	-
145	Acetylation	VAIALAHKYH----- HHHHHHHHCC-----	39.14	30589095

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HBE_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HBE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HBE_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HBE_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-36, AND MASSSPECTROMETRY.
PubMed: 18083107