LYPA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LYPA2_HUMAN
• UniProt AC: O95372
• Protein Name: Acyl-protein thioesterase 2
• Gene Name: LYPLA2
• Organism: Homo sapiens (Human).
• Sequence Length: 231
• Subcellular Localization: Cytoplasm .
• Protein Description: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. [PubMed: 21152083]
• Protein Sequence: MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAILQCHGELDPMVPVRFGALTAEKLRSVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	S-palmitoylation	------MCGNTMSVP ------CCCCCCCCE	6.06	28826475
18	Phosphorylation	LTDAATVSGAERETA ECCCCCCCCCHHHHE	28.12	22210691
39	Phosphorylation	GLGDTGHSWADALST CCCCCCCCHHHHHHH	25.88	21406692
45	Phosphorylation	HSWADALSTIRLPHV CCHHHHHHHCCCCCC	24.41	21406692
46	Phosphorylation	SWADALSTIRLPHVK CHHHHHHHCCCCCCE	15.80	21406692
53	Ubiquitination	TIRLPHVKYICPHAP HCCCCCCEEECCCCC	26.34	-
53	Acetylation	TIRLPHVKYICPHAP HCCCCCCEEECCCCC	26.34	25953088
54	Phosphorylation	IRLPHVKYICPHAPR CCCCCCEEECCCCCC	13.48	28152594
56	S-nitrosocysteine	LPHVKYICPHAPRIP CCCCEEECCCCCCCC	1.51	-
56	S-nitrosylation	LPHVKYICPHAPRIP CCCCEEECCCCCCCC	1.51	19483679
82	Phosphorylation	WFDLMGLSPDAPEDE HHHHHCCCCCCCCCH	18.27	28348404
93	Ubiquitination	PEDEAGIKKAAENIK CCCHHHHHHHHHHHH	35.13	-
100	Ubiquitination	KKAAENIKALIEHEM HHHHHHHHHHHHHHH	49.04	21890473
107	Sulfoxidation	KALIEHEMKNGIPAN HHHHHHHHHHCCCCC	4.39	30846556
108	Acetylation	ALIEHEMKNGIPANR HHHHHHHHHCCCCCC	49.38	25953088
108	Ubiquitination	ALIEHEMKNGIPANR HHHHHHHHHCCCCCC	49.38	21890473
164	Ubiquitination	QAANGSAKDLAILQC HHHCCCHHHEEEEEE	55.78	-
178	Sulfoxidation	CHGELDPMVPVRFGA ECCCCCCCCCCEECC	5.48	30846556
190	Acetylation	FGALTAEKLRSVVTP ECCCCHHHHHHCCCC	46.89	25953088
190	Ubiquitination	FGALTAEKLRSVVTP ECCCCHHHHHHCCCC	46.89	21890473
193	Phosphorylation	LTAEKLRSVVTPARV CCHHHHHHCCCCCEE	31.23	28857561
203	Ubiquitination	TPARVQFKTYPGVMH CCCEEEEECCCCCCC	30.02	-
221	Ubiquitination	PQEMAAVKEFLEKLL HHHHHHHHHHHHHHC	37.71	-
226	Ubiquitination	AVKEFLEKLLPPV-- HHHHHHHHHCCCC--	58.43	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LYPA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LYPA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LYPA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DKC1_HUMAN	DKC1	physical	16169070
SCMH1_HUMAN	SCMH1	physical	16169070
MED31_HUMAN	MED31	physical	16169070
A4_HUMAN	APP	physical	21832049
APT_HUMAN	APRT	physical	26344197
EI2BA_HUMAN	EIF2B1	physical	26344197
LACB2_HUMAN	LACTB2	physical	26344197
SPRE_HUMAN	SPR	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.