ITAD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ITAD_HUMAN
• UniProt AC: Q13349
• Protein Name: Integrin alpha-D
• Gene Name: ITGAD
• Organism: Homo sapiens (Human).
• Sequence Length: 1161
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood..
• Protein Sequence: MTFGTVLLLSVLASYHGFNLDVEEPTIFQEDAGGFGQSVVQFGGSRLVVGAPLEVVAANQTGRLYDCAAATGMCQPIPLHIRPEAVNMSLGLTLAASTNGSRLLACGPTLHRVCGENSYSKGSCLLLGSRWEIIQTVPDATPECPHQEMDIVFLIDGSGSIDQNDFNQMKGFVQAVMGQFEGTDTLFALMQYSNLLKIHFTFTQFRTSPSQQSLVDPIVQLKGLTFTATGILTVVTQLFHHKNGARKSAKKILIVITDGQKYKDPLEYSDVIPQAEKAGIIRYAIGVGHAFQGPTARQELNTISSAPPQDHVFKVDNFAALGSIQKQLQEKIYAVEGTQSRASSSFQHEMSQEGFSTALTMDGLFLGAVGSFSWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQNLVLGAPRYQHTGKAVIFTQVSRQWRKKAEVTGTQIGSYFGASLCSVDVDSDGSTDLILIGAPHYYEQTRGGQVSVCPLPRGRVQWQCDAVLRGEQGHPWGRFGAALTVLGDVNEDKLIDVAIGAPGEQENRGAVYLFHGASESGISPSHSQRIASSQLSPRLQYFGQALSGGQDLTQDGLMDLAVGARGQVLLLRSLPVLKVGVAMRFSPVEVAKAVYRCWEEKPSALEAGDATVCLTIQKSSLDQLGDIQSSVRFDLALDPGRLTSRAIFNETKNPTLTRRKTLGLGIHCETLKLLLPDCVEDVVSPIILHLNFSLVREPIPSPQNLRPVLAVGSQDLFTASLPFEKNCGQDGLCEGDLGVTLSFSGLQTLTVGSSLELNVIVTVWNAGEDSYGTVVSLYYPAGLSHRRVSGAQKQPHQSALRLACETVPTEDEGLRSSRCSVNHPIFHEGSNGTFIVTFDVSYKATLGDRMLMRASASSENNKASSSKATFQLELPVKYAVYTMISRQEESTKYFNFATSDEKKMKEAEHRYRVNNLSQRDLAISINFWVPVLLNGVAVWDVVMEAPSQSLPCVSERKPPQHSDFLTQISRSPMLDCSIADCLQFRCDVPSFSVQEELDFTLKGNLSFGWVRETLQKKVLVVSVAEITFDTSVYSQLPGQEAFMRAQMEMVLEEDEVYNAIPIIMGSSVGALLLLALITATLYKLGFFKRHYKEMLEDKPEDTATFSGDDFSCVAPNVPLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	N-linked_Glycosylation	PLEVVAANQTGRLYD CEEEEEECCCCCCCC	30.15	UniProtKB CARBOHYD
71	Phosphorylation	LYDCAAATGMCQPIP CCCHHHHCCCCEEEC	22.26	22210691
87	N-linked_Glycosylation	HIRPEAVNMSLGLTL CCCHHHHCCCCCCEE	22.75	UniProtKB CARBOHYD
89	Phosphorylation	RPEAVNMSLGLTLAA CHHHHCCCCCCEEEE	17.68	22210691
99	N-linked_Glycosylation	LTLAASTNGSRLLAC CEEEECCCCCEEEEE	43.90	UniProtKB CARBOHYD
119	Phosphorylation	RVCGENSYSKGSCLL HHCCCCCCCCCCEEE	26.44	-
391	N-linked_Glycosylation	NMSPTFINMSQENVD CCCCCEEECCCCCCC	21.62	UniProtKB CARBOHYD
573	Phosphorylation	SHSQRIASSQLSPRL CHHHHHHHCCCCHHH	19.08	25003641
577	Phosphorylation	RIASSQLSPRLQYFG HHHHCCCCHHHHHHH	10.59	25003641
582	Phosphorylation	QLSPRLQYFGQALSG CCCHHHHHHHHHHHC	17.80	22210691
588	Phosphorylation	QYFGQALSGGQDLTQ HHHHHHHHCCCCCCH	43.84	22210691
614	Phosphorylation	GQVLLLRSLPVLKVG CEEEEEECCCEEEEE	36.67	-
627	Phosphorylation	VGVAMRFSPVEVAKA EEEEECCCHHHHHHH	20.05	-
690	N-linked_Glycosylation	LTSRAIFNETKNPTL CHHHHHHCCCCCCCC	50.33	UniProtKB CARBOHYD
732	N-linked_Glycosylation	SPIILHLNFSLVREP HHHHHEECCCEECCC	17.45	UniProtKB CARBOHYD
839	Phosphorylation	AQKQPHQSALRLACE CCCCCCHHHHHHHHC	26.66	28787133
847	Phosphorylation	ALRLACETVPTEDEG HHHHHHCCCCCCCCC	31.50	28787133
850	Phosphorylation	LACETVPTEDEGLRS HHHCCCCCCCCCCCC	52.29	28787133
872	N-linked_Glycosylation	PIFHEGSNGTFIVTF CEEEECCCCEEEEEE	65.46	UniProtKB CARBOHYD
886	Phosphorylation	FDVSYKATLGDRMLM EEEEEEEECHHHHHH	27.41	-
896	Phosphorylation	DRMLMRASASSENNK HHHHHHCCCCCCCCC	20.51	22210691
919	Phosphorylation	QLELPVKYAVYTMIS EEECCCEEHHEEEEC	11.09	27174698
922	Phosphorylation	LPVKYAVYTMISRQE CCCEEHHEEEECCCH	5.17	27174698
923	Phosphorylation	PVKYAVYTMISRQEE CCEEHHEEEECCCHH	11.05	27174698
926	Phosphorylation	YAVYTMISRQEESTK EHHEEEECCCHHHHH	19.65	27174698
931	Phosphorylation	MISRQEESTKYFNFA EECCCHHHHHCCCCC	29.46	27174698
932	Phosphorylation	ISRQEESTKYFNFAT ECCCHHHHHCCCCCC	32.80	27174698
934	Phosphorylation	RQEESTKYFNFATSD CCHHHHHCCCCCCCC	12.12	27174698
956	N-linked_Glycosylation	EHRYRVNNLSQRDLA HHHHHHCCCCHHCCE	37.91	UniProtKB CARBOHYD
958	Phosphorylation	RYRVNNLSQRDLAIS HHHHCCCCHHCCEEE	25.87	22210691
1045	N-linked_Glycosylation	LDFTLKGNLSFGWVR ECEEEECCCCCHHHH	30.81	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ITAD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ITAD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ITAD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ITB2_HUMAN	ITGB2	physical	8777714
ICAM3_HUMAN	ICAM3	physical	8777714
SHRPN_HUMAN	SHARPIN	physical	24210817

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.