CCL22_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCL22_HUMAN
• UniProt AC: O00626
• Protein Name: C-C motif chemokine 22
• Gene Name: CCL22
• Organism: Homo sapiens (Human).
• Sequence Length: 93
• Subcellular Localization: Secreted.
• Protein Description: May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active..
• Protein Sequence: MDRLQTALLVVLVLLAVALQATEAGPYGANMEDSVCCRDYVRYRLPLRVVKHFYWTSDSCPRPGVVLLTFRDKEICADPRVPWVKMILNKLSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Phosphorylation	LRVVKHFYWTSDSCP EEEEEEEEECCCCCC	13.90	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCL22_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCL22_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCL22_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCR4_HUMAN	CCR4	physical	9430724
CRYAB_HUMAN	CRYAB	physical	21988832
GSH1_HUMAN	GCLC	physical	21988832
HERC3_HUMAN	HERC3	physical	21988832
KDM4A_HUMAN	KDM4A	physical	28514442
SPS2_HUMAN	SEPHS2	physical	28514442
PRUN1_HUMAN	PRUNE	physical	28514442
DPP8_HUMAN	DPP8	physical	28514442
GLSK_HUMAN	GLS	physical	28514442
PDIA5_HUMAN	PDIA5	physical	28514442
EME1_HUMAN	EME1	physical	28514442
F118B_HUMAN	FAM118B	physical	28514442
ITPA_HUMAN	ITPA	physical	28514442
RA51D_HUMAN	RAD51D	physical	28514442
CHD1L_HUMAN	CHD1L	physical	28514442
ITA8_HUMAN	ITGA8	physical	28514442
PREP_HUMAN	PITRM1	physical	28514442
CBWD1_HUMAN	CBWD1	physical	28514442
PLXA2_HUMAN	PLXNA2	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
LONF2_HUMAN	LONRF2	physical	28514442
CD109_HUMAN	CD109	physical	28514442
LCAP_HUMAN	LNPEP	physical	28514442
PPM1A_HUMAN	PPM1A	physical	28514442
HS12A_HUMAN	HSPA12A	physical	28514442
YTHD1_HUMAN	YTHDF1	physical	28514442
DUSTY_HUMAN	DSTYK	physical	28514442
TAB1_HUMAN	TAB1	physical	28514442
OAF_HUMAN	OAF	physical	28514442
EF1A1_HUMAN	EEF1A1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.