PRUN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRUN1_HUMAN
• UniProt AC: Q86TP1
• Protein Name: Exopolyphosphatase PRUNE1
• Gene Name: PRUNE1 {ECO:0000312|HGNC:HGNC:13420}
• Organism: Homo sapiens (Human).
• Sequence Length: 453
• Subcellular Localization: Cytoplasm. Nucleus. Cell junction, focal adhesion. In some transfected cells a nuclear staining is also observed.
• Protein Description: Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. [PubMed: 28334956 Involved in the regulation of microtubule polymerization]
• Protein Sequence: MEDYLQGCRAALQESRPLHVVLGNEACDLDSTVSALALAFYLAKTTEAEEVFVPVLNIKRSELPLRGDIVFFLQKVHIPESILIFRDEIDLHALYQAGQLTLILVDHHILSKSDTALEEAVAEVLDHRPIEPKHCPPCHVSVELVGSCATLVTERILQGAPEILDRQTAALLHGTIILDCVNMDLKIGKATPKDSKYVEKLEALFPDLPKRNDIFDSLQKAKFDVSGLTTEQMLRKDQKTIYRQGVKVAISAIYMDLEAFLQRSNLLADLHAFCQAHSYDVLVAMTIFFNTHNEPVRQLAIFCPHVALQTTICEVLERSHSPPLKLTPASSTHPNLHAYLQGNTQVSRKKLLPLLQEALSAYFDSMKIPSGQPETADVSREQVDKELDRASNSLISGLSQDEEDPPLPPTPMNSLVDECPLDQGLPKLSAEAVFEKCSQISLSQSTTASLSKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEDYLQGC -------CHHHHHHH		22814378
18	Ubiquitination	ALQESRPLHVVLGNE HHHHCCCCEEEECCC		29967540
28	Ubiquitination	VLGNEACDLDSTVSA EECCCCCCCHHHHHH		29967540
40	Ubiquitination	VSALALAFYLAKTTE HHHHHHHHHHHCCCC		29967540
200	Ubiquitination	KDSKYVEKLEALFPD CCCHHHHHHHHHCCC		29967540
210	Ubiquitination	ALFPDLPKRNDIFDS HHCCCCCCCCCHHHH		29967540
220	Ubiquitination	DIFDSLQKAKFDVSG CHHHHHHHHCCCCCC		-
222	Ubiquitination	FDSLQKAKFDVSGLT HHHHHHHCCCCCCCC		29967540
226	Phosphorylation	QKAKFDVSGLTTEQM HHHCCCCCCCCHHHH		27174698
229	Phosphorylation	KFDVSGLTTEQMLRK CCCCCCCCHHHHHHH		27174698
230	Phosphorylation	FDVSGLTTEQMLRKD CCCCCCCHHHHHHHC		27174698
319	Phosphorylation	ICEVLERSHSPPLKL HHHHHHHCCCCCCCC		29396449
321	Phosphorylation	EVLERSHSPPLKLTP HHHHHCCCCCCCCCC		25849741
331	Phosphorylation	LKLTPASSTHPNLHA CCCCCCCCCCCCHHH		-
332	Phosphorylation	KLTPASSTHPNLHAY CCCCCCCCCCCHHHH		-
360	Phosphorylation	PLLQEALSAYFDSMK HHHHHHHHHHHHHCC		29083192
362	Phosphorylation	LQEALSAYFDSMKIP HHHHHHHHHHHCCCC		29083192
365	Phosphorylation	ALSAYFDSMKIPSGQ HHHHHHHHCCCCCCC		29083192
379	Phosphorylation	QPETADVSREQVDKE CCCCCCCCHHHHHHH		28555341
391	Phosphorylation	DKELDRASNSLISGL HHHHHHHHHHHHHCC		28060719
393	Phosphorylation	ELDRASNSLISGLSQ HHHHHHHHHHHCCCC		28060719
396	Phosphorylation	RASNSLISGLSQDEE HHHHHHHHCCCCCCC		28060719
399	Phosphorylation	NSLISGLSQDEEDPP HHHHHCCCCCCCCCC		28102081
410	Phosphorylation	EDPPLPPTPMNSLVD CCCCCCCCCCHHHCC		28060719
414	Phosphorylation	LPPTPMNSLVDECPL CCCCCCHHHCCCCCC		28060719

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRUN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRUN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRUN1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PRUN1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.