CCR4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCR4_HUMAN
• UniProt AC: P51679
• Protein Name: C-C chemokine receptor type 4
• Gene Name: CCR4
• Organism: Homo sapiens (Human).
• Sequence Length: 360
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival..
• Protein Sequence: MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	O-linked_Glycosylation	TLDESIYSNYYLYES CCCHHHHHCCCCHHC	19.38	OGP
183	N-linked_Glycosylation	STCYTERNHTYCKTK HHHECCCCCCEEEEE	26.14	UniProtKB CARBOHYD
191	Phosphorylation	HTYCKTKYSLNSTTW CCEEEEEEECCCCHH	24.50	-
194	N-linked_Glycosylation	CKTKYSLNSTTWKVL EEEEEECCCCHHHHH	31.22	17660510

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCR4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCR4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCR4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARBK1_HUMAN	ADRBK1	physical	10754297
ARBK2_HUMAN	ADRBK2	physical	10754297
CCL5_HUMAN	CCL5	physical	8573157
CCL3_HUMAN	CCL3	physical	8573157
ZN335_HUMAN	ZNF335	physical	18180299

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D09761: Mogamulizumab (genetical recombination) (JAN); Mogamulizumab (USAN); KW-0761; Poteligeo (TN)
• DrugBank
• There are no disease associations of PTM sites.