dbPTM

ARBK2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ARBK2_HUMAN
UniProt AC	P35626
Protein Name	Beta-adrenergic receptor kinase 2
Gene Name	GRK3 {ECO:0000312\|MIM:109636}
Organism	Homo sapiens (Human).
Sequence Length	688
Subcellular Localization
Protein Description	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors..
Protein Sequence	MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKPRSGTVELPKPSLCHRNSNGL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	AVLADVSYLMAMEKS HHHHHHHHHHHHHHC	10.59	16725308
45	Ubiquitination	SIRSVMQKYLAERNE HHHHHHHHHHHHHCC	24.92	-
57	Ubiquitination	RNEITFDKIFNQKIG HCCCCHHHHHHHHHH	45.03	-
62	Ubiquitination	FDKIFNQKIGFLLFK HHHHHHHHHHHHHHH	45.99	-
84	Ubiquitination	NEAVPQVKFYEEIKE HHHCHHHHHHHHHHH	36.66	-
90	Ubiquitination	VKFYEEIKEYEKLDN HHHHHHHHHHHHCCC	58.48	-
94	Ubiquitination	EEIKEYEKLDNEEDR HHHHHHHHCCCHHHH	61.31	-
109	Phosphorylation	LCRSRQIYDAYIMKE HHHHHHHHHHHHHHH	6.03	22817900
112	Phosphorylation	SRQIYDAYIMKELLS HHHHHHHHHHHHHHC	9.92	22817900
115	Ubiquitination	IYDAYIMKELLSCSH HHHHHHHHHHHCCCC	35.33	-
119	Phosphorylation	YIMKELLSCSHPFSK HHHHHHHCCCCCCCH	26.63	29083192
121	Phosphorylation	MKELLSCSHPFSKQA HHHHHCCCCCCCHHH	30.71	24719451
125	Phosphorylation	LSCSHPFSKQAVEHV HCCCCCCCHHHHHHH	28.45	29083192
126	Ubiquitination	SCSHPFSKQAVEHVQ CCCCCCCHHHHHHHH	42.53	-
138	Ubiquitination	HVQSHLSKKQVTSTL HHHHHHCHHHHHHHH	54.29	-
139	Ubiquitination	VQSHLSKKQVTSTLF HHHHHCHHHHHHHHH	46.77	-
164	Ubiquitination	LRGDIFQKFMESDKF HCCCHHHHHHHCCCC	35.61	-
170	Ubiquitination	QKFMESDKFTRFCQW HHHHHCCCCHHHHCC	58.89	-
206	Phosphorylation	RGGFGEVYGCRKADT CCCCCCCCCCCCCCC	13.25	-
213	Phosphorylation	YGCRKADTGKMYAMK CCCCCCCCCCEEEEH	43.49	22964224
215	Ubiquitination	CRKADTGKMYAMKCL CCCCCCCCEEEEHHH	30.72	-
220	Ubiquitination	TGKMYAMKCLDKKRI CCCEEEEHHHCHHHC	24.39	-
230	Ubiquitination	DKKRIKMKQGETLAL CHHHCCCCCCCEEEE	50.58	-
247	Phosphorylation	RIMLSLVSTGDCPFI HHHHHHHCCCCCCEE	31.78	22817900
248	Phosphorylation	IMLSLVSTGDCPFIV HHHHHHCCCCCCEEE	29.56	-
319	Ubiquitination	FVVYRDLKPANILLD EEEEECCCHHHEEEC	46.50	-
344	Ubiquitination	GLACDFSKKKPHASV CCCCCCCCCCCCCCC	65.88	-
345	Ubiquitination	LACDFSKKKPHASVG CCCCCCCCCCCCCCC	71.04	-
346	Ubiquitination	ACDFSKKKPHASVGT CCCCCCCCCCCCCCC	45.85	-
350	Phosphorylation	SKKKPHASVGTHGYM CCCCCCCCCCCCCCC	20.32	19369195
353	Phosphorylation	KPHASVGTHGYMAPE CCCCCCCCCCCCCHH	15.24	22817900
356	Phosphorylation	ASVGTHGYMAPEVLQ CCCCCCCCCCHHHHH	5.19	-
389	Phosphorylation	FKLLRGHSPFRQHKT HHHHHCCCHHHHCCC	28.67	27067055
406	Phosphorylation	KHEIDRMTLTVNVEL HHHCCEEEEEEEEEC	21.85	21406692
408	Phosphorylation	EIDRMTLTVNVELPD HCCEEEEEEEEECCC	10.81	21406692
416	Phosphorylation	VNVELPDTFSPELKS EEEECCCCCCHHHHH	24.87	21406692
418	Phosphorylation	VELPDTFSPELKSLL EECCCCCCHHHHHHH	21.40	24719451
423	Phosphorylation	TFSPELKSLLEGLLQ CCCHHHHHHHHHHHH	51.30	21406692
448	Ubiquitination	GGGSQEVKEHSFFKG CCCCHHHHHCCCCCC	49.29	-
454	Ubiquitination	VKEHSFFKGVDWQHV HHHCCCCCCCCCEEE	56.89	-
465	Ubiquitination	WQHVYLQKYPPPLIP CEEEEECCCCCCCCC	58.07	-
487	Phosphorylation	ADAFDIGSFDEEDTK HHCCCCCCCCHHHCC	29.83	29978859
493	Phosphorylation	GSFDEEDTKGIKLLD CCCCHHHCCCEEEEE	34.15	27732954
494	Ubiquitination	SFDEEDTKGIKLLDC CCCHHHCCCEEEEEC	71.59	-
497	Ubiquitination	EEDTKGIKLLDCDQE HHHCCCEEEEECCHH	52.22	-
506	Phosphorylation	LDCDQELYKNFPLVI EECCHHHHHHCCEEE	11.79	27642862
507	Ubiquitination	DCDQELYKNFPLVIS ECCHHHHHHCCEEEE	65.81	-
514	Phosphorylation	KNFPLVISERWQQEV HHCCEEEEHHHHHHH	17.40	21406692
522	Phosphorylation	ERWQQEVTETVYEAV HHHHHHHHHHHHHHH	25.78	22210691
524	Phosphorylation	WQQEVTETVYEAVNA HHHHHHHHHHHHHHC	21.01	28796482
526	Phosphorylation	QEVTETVYEAVNADT HHHHHHHHHHHHCCH	12.94	28796482
533	Phosphorylation	YEAVNADTDKIEARK HHHHHCCHHHHHHHH	36.46	22210691
545	Ubiquitination	ARKRAKNKQLGHEED HHHHHHHHCCCCHHH	46.31	-
564	Phosphorylation	KDCIMHGYMLKLGNP HHHHHHCHHHHCCCC	5.65	-
612	Phosphorylation	QILSVEETQIKDKKC HHHCCCHHHCCCCEE	23.30	-
625	Acetylation	KCILFRIKGGKQFVL EEEEEEEECCEEEEE	58.30	7959355
628	Ubiquitination	LFRIKGGKQFVLQCE EEEEECCEEEEEEEC	49.59	-
628	Acetylation	LFRIKGGKQFVLQCE EEEEECCEEEEEEEC	49.59	7959367
644	Ubiquitination	DPEFVQWKKELNETF CHHHHHHHHHHHHHH	21.19	-
645	Ubiquitination	PEFVQWKKELNETFK HHHHHHHHHHHHHHH	65.56	-
652	Acetylation	KELNETFKEAQRLLR HHHHHHHHHHHHHHH	60.61	25953088
652	Ubiquitination	KELNETFKEAQRLLR HHHHHHHHHHHHHHH	60.61	-
670	Phosphorylation	KFLNKPRSGTVELPK HHHCCCCCCCCCCCC	47.55	28634120
672	Phosphorylation	LNKPRSGTVELPKPS HCCCCCCCCCCCCCC	16.44	-
679	Phosphorylation	TVELPKPSLCHRNSN CCCCCCCCCCCCCCC	50.16	30576142
685	Phosphorylation	PSLCHRNSNGL---- CCCCCCCCCCC----	32.03	23898821

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:20804422

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ARBK2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ARBK2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CXCR4_HUMAN	CXCR4	physical	11668182

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00171	Adenosine triphosphate

Regulatory Network of ARBK2_HUMAN

Related Literatures of Post-Translational Modification