CH034_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CH034_HUMAN
• UniProt AC: Q49A92
• Protein Name: Uncharacterized protein C8orf34
• Gene Name: C8orf34
• Organism: Homo sapiens (Human).
• Sequence Length: 538
• Protein Sequence: MSSPLASELSELAALRPGFRLSAPHARVAPRAATHARGRGRASHAGQPRLRSSCPGPSPGKRRVVPSGGAQPRVLPALSSRSHLFPMASHPQTRIQAYLEKNKIGPLFEELMTKLITETPDQPIPFLIDHLQSKQGNRGQLQRTLSGSAALWAESEKSESKGTRRDFRSYDKPWQLNAKKPKKSKSDLAVSNISPPSPDSKSLPRSVEHPKWNWRTKPQSRDFDELNHILQESKKLGKALENLSRSIAISDELDKETVTFNSSLLRPRVIGEWIGREENDADPLAAEMLQPPIPRSKNDQWESEDSGSSPAGSLKMEPKNKGLKQQQQQHKKLLAAMLSQDSFESIHSPTPSVTEEDIDNEDDAMELLEDLNDLRMEGVTTLVPSGSKFNQGRPTYPAEPQAKVTLNICSRCARLQGDNLEERTEESLPILHSPDEKIPDSFDSLPGTEEALMEEGDEFEKASKLTGPGEASSGVGHSLKNYMEEDESLKQLQVVHQPWILPSDTESEGVEAEQEKRSADLLLCVPCSSCPTLVYSGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 6)	Phosphorylation	-	19.29	27732954
3 (in isoform 6)	Phosphorylation	-	34.11	27732954
3	Phosphorylation	-----MSSPLASELS -----CCCHHHHHHH	34.11	29514088
7 (in isoform 6)	Phosphorylation	-	33.90	27732954
7	Phosphorylation	-MSSPLASELSELAA -CCCHHHHHHHHHHH	33.90	29514088
10 (in isoform 6)	Phosphorylation	-	22.21	24719451
10	Phosphorylation	SPLASELSELAALRP CHHHHHHHHHHHHCC	22.21	24719451
12	Phosphorylation	LASELSELAALRPGF HHHHHHHHHHHCCCC	10.06	29514088
33	Phosphorylation	ARVAPRAATHARGRG CCCCCCHHHHHCCCC	24.42	25332170
72	Phosphorylation	VPSGGAQPRVLPALS CCCCCCCCCCHHCCC	42.95	-
83	Phosphorylation	PALSSRSHLFPMASH HCCCCCCCCCCCCCC	37.36	-
84	Phosphorylation	ALSSRSHLFPMASHP CCCCCCCCCCCCCCC	24.59	-
98	Phosphorylation	PQTRIQAYLEKNKIG CHHHHHHHHHHCCCH	43.44	28857561
108	Phosphorylation	KNKIGPLFEELMTKL HCCCHHHHHHHHHHH	34.70	-
111	Phosphorylation	IGPLFEELMTKLITE CHHHHHHHHHHHHHC	44.73	28857561
114	Phosphorylation	LFEELMTKLITETPD HHHHHHHHHHHCCCC	27.77	24719451
158	Phosphorylation	LWAESEKSESKGTRR HHHHCCCCCCCCCCC	35.25	-
177	Phosphorylation	YDKPWQLNAKKPKKS CCCCCCCCCCCCCCC	32.31	24719451
197	Phosphorylation	VSNISPPSPDSKSLP CCCCCCCCCCCCCCC	26.14	19413330
210	Phosphorylation	LPRSVEHPKWNWRTK CCCCCCCCCCCCCCC	30.38	24719451
220	Phosphorylation	NWRTKPQSRDFDELN CCCCCCCCCCHHHHH	36.20	23532336
233	Acetylation	LNHILQESKKLGKAL HHHHHHHHHHHHHHH	58.97	-
235	Acetylation	HILQESKKLGKALEN HHHHHHHHHHHHHHH	72.28	7834081
301	Phosphorylation	PRSKNDQWESEDSGS CCCCCCCCCCCCCCC	38.11	32142685
347	Phosphorylation	QDSFESIHSPTPSVT HHCHHHCCCCCCCCC	30.51	22985185
378	Acetylation	LNDLRMEGVTTLVPS HHHHHHCCCEEECCC	55.73	-
386	Phosphorylation	VTTLVPSGSKFNQGR CEEECCCCCCCCCCC	24.27	28634298
387	Phosphorylation	TTLVPSGSKFNQGRP EEECCCCCCCCCCCC	44.54	28634298
392	Phosphorylation	SGSKFNQGRPTYPAE CCCCCCCCCCCCCCC	34.80	23186163
419	Phosphorylation	CARLQGDNLEERTEE HHHHCCCCHHHHCHH	45.83	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CH034_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CH034_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CH034_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CH034_HUMAN	C8orf34	physical	25416956
ASB7_HUMAN	ASB7	physical	26186194
CNDP2_HUMAN	CNDP2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111, AND MASSSPECTROMETRY.
PubMed: 19413330