CNGB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNGB1_HUMAN
• UniProt AC: Q14028
• Protein Name: Cyclic nucleotide-gated cation channel beta-1
• Gene Name: CNGB1
• Organism: Homo sapiens (Human).
• Sequence Length: 1251
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP.; Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties: it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit..
• Protein Sequence: MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFKEEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHSITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVWRDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQAQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQVEPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEEEEEEEEEEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEKAKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLMAEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSDPTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKPSPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRSNNKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELAALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSPPPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	Phosphorylation	ETKEAALTSTISLRA HHHHHHHHHHEEHHH	21.06	25690035
84	Phosphorylation	AALTSTISLRAQGAE HHHHHHEEHHHCCCC	16.34	25690035
104	Phosphorylation	SPSRRVLTWLMKGVE CCHHHHHHHHHHCHH	17.44	-
494	Phosphorylation	STVLPPPSPAKSDTL CCCCCCCCCCCCCEE	43.17	-
517	Phosphorylation	THRKKLPSEDDEAEE CCCCCCCCCCCHHHH	65.18	29457462
592	Phosphorylation	KLIDPDVTSDEESPK HHCCCCCCCCCCCCC	37.53	27732954
593	Phosphorylation	LIDPDVTSDEESPKP HCCCCCCCCCCCCCC	42.76	24719451
597	Phosphorylation	DVTSDEESPKPSPAK CCCCCCCCCCCCCCC	35.85	24719451
777	Phosphorylation	MAFFEFNSRLESILS HHHHHCHHHHHHHHH	43.49	26074081
781	Phosphorylation	EFNSRLESILSKAYV HCHHHHHHHHHHHHH	33.16	26074081
784	Phosphorylation	SRLESILSKAYVYRV HHHHHHHHHHHHHHH	17.36	26074081
787	Phosphorylation	ESILSKAYVYRVIRT HHHHHHHHHHHHHHH	11.18	26074081
789	Phosphorylation	ILSKAYVYRVIRTTA HHHHHHHHHHHHHHH	6.11	26074081
842	Phosphorylation	CYYFAVKTLITIGGL HHHHEEEEHHHCCCC	19.45	-
854	Phosphorylation	GGLPDPKTLFEIVFQ CCCCCHHHHHHHHHH	41.91	26074081
865	Phosphorylation	IVFQLLNYFTGVFAF HHHHHHHHHHHHHHH	11.50	26074081
867	Phosphorylation	FQLLNYFTGVFAFSV HHHHHHHHHHHHHHH	23.29	26074081
873	Phosphorylation	FTGVFAFSVMIGQMR HHHHHHHHHHHHCHH	13.82	26074081
895	Phosphorylation	AGQTYYRSCMDSTVK CCCHHHHHHHHHHHH	9.55	-
899	Phosphorylation	YYRSCMDSTVKYMNF HHHHHHHHHHHHCEE	14.28	-
903	Phosphorylation	CMDSTVKYMNFYKIP HHHHHHHHCEECCCC	7.92	-
919	Phosphorylation	SVQNRVKTWYEYTWH HHHHHHCHHHHHCCC	30.35	-
980	Phosphorylation	DMLKRLRSVVYLPND HHHHHHHHCEECCCC	22.11	-
1026	Phosphorylation	LVTLKAGSVFGEISL EEEEECCCCEEEEEE	21.09	27174698
1032	Phosphorylation	GSVFGEISLLAVGGG CCCEEEEEEEEECCC	17.02	27174698
1095	Phosphorylation	NKPKEEKSVLILPPR CCCCCCCCEEEECCC	25.99	-
1105	Phosphorylation	ILPPRAGTPKLFNAA EECCCCCCHHHHHHH	19.10	28978645
1239	Phosphorylation	EPGEQILSVKMPEER CCCCCEEEEECCHHH	22.71	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CNGB1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNGB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNGB1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CNGB1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.