OLIG2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OLIG2_HUMAN
• UniProt AC: Q13516
• Protein Name: Oligodendrocyte transcription factor 2
• Gene Name: OLIG2
• Organism: Homo sapiens (Human).
• Sequence Length: 323
• Subcellular Localization: Nucleus . Cytoplasm. The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2..
• Protein Description: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity)..
• Protein Sequence: MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSAELRGAMGSAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEIYGGHHAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSSASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPCPCSMCQVPPPHHHVSAMGAGSLPRLTSDAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	DSDASLVSSRPSSPE CCCHHHCCCCCCCCC	26.39	24719451
29	Phosphorylation	LPARSKGSSGSAFTG ECCCCCCCCCCCCCC	34.95	29083192
30	Phosphorylation	PARSKGSSGSAFTGG CCCCCCCCCCCCCCC	45.49	29083192
32	Phosphorylation	RSKGSSGSAFTGGTV CCCCCCCCCCCCCCC	23.35	29083192
35	Phosphorylation	GSSGSAFTGGTVSSS CCCCCCCCCCCCCCC	34.12	29083192
38	Phosphorylation	GSAFTGGTVSSSTPS CCCCCCCCCCCCCCC	20.68	29083192
40	Phosphorylation	AFTGGTVSSSTPSDC CCCCCCCCCCCCCCC	20.57	29083192
41	Phosphorylation	FTGGTVSSSTPSDCP CCCCCCCCCCCCCCC	33.62	29083192
42	Phosphorylation	TGGTVSSSTPSDCPP CCCCCCCCCCCCCCH	36.51	29083192
43	Phosphorylation	GGTVSSSTPSDCPPE CCCCCCCCCCCCCHH	28.85	29083192
45	Phosphorylation	TVSSSTPSDCPPELS CCCCCCCCCCCHHHC	52.51	29083192
61	Phosphorylation	ELRGAMGSAGAHPGD HHHHHHHCCCCCCCC	15.50	-
73	Phosphorylation	PGDKLGGSGFKSSSS CCCCCCCCCCCCCCC	38.98	-
77	Phosphorylation	LGGSGFKSSSSSTSS CCCCCCCCCCCCCCC	32.94	-
80	Phosphorylation	SGFKSSSSSTSSSTS CCCCCCCCCCCCCCC	39.31	-
83	Phosphorylation	KSSSSSTSSSTSSAA CCCCCCCCCCCCCHH	25.00	-
84	Phosphorylation	SSSSSTSSSTSSAAA CCCCCCCCCCCCHHH	37.41	-
85	Phosphorylation	SSSSTSSSTSSAAAS CCCCCCCCCCCHHHH	31.88	-
151	Phosphorylation	RKLSKIATLLLARNY HHHHHHHHHHHHHHH	22.78	-
163	Phosphorylation	RNYILMLTNSLEEMK HHHHHHHCCCHHHHH	14.59	-
165	Phosphorylation	YILMLTNSLEEMKRL HHHHHCCCHHHHHHH	31.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OLIG2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OLIG2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OLIG2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of OLIG2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.