AT11A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AT11A_HUMAN
• UniProt AC: P98196
• Protein Name: Probable phospholipid-transporting ATPase IH
• Gene Name: ATP11A
• Organism: Homo sapiens (Human).
• Sequence Length: 1134
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Early endosome . Recycling endosome . Endoplasmic reticulum . Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in th
• Protein Description: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib..
• Protein Sequence: MDCSLVRTLVHRYCAGEENWVDSRTIYVGHREPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLIIFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSSNRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLHATIECEQPQPDLYKFVGRINVYSDLNDPVVRPLGSENLLLRGATLKNTEKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVLKYMWQSEPFRDEPWYNQKTESERQRNLFLKAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMEFKECCIEGHVYVPHVICNGQVLPESSGIDMIDSSPSVNGREREELFFRALCLCHTVQVKDDDSVDGPRKSPDGGKSCVYISSSPDEVALVEGVQRLGFTYLRLKDNYMEILNRENHIERFELLEILSFDSVRRRMSVIVKSATGEIYLFCKGADSSIFPRVIEGKVDQIRARVERNAVEGLRTLCVAYKRLIQEEYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQLLELTTKRIEEQSLHDVLFELSKTVLRHSGSLTRDNLSGLSADMQDYGLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRMAPLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYKNVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDVAKNALLRWRVFIYWTLLGLFDALVFFFGAYFVFENTTVTSNGQIFGNWTFGTLVFTVMVFTVTLKLALDTHYWTWINHFVIWGSLLFYVVFSLLWGGVIWPFLNYQRMYYVFIQMLSSGPAWLAIVLLVTISLLPDVLKKVLCRQLWPTATERVQTKSQCLSVEQSTIFMLSQTSSSLSF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MDCSLVRTLVH ----CCHHHHHHHHH	42.08	24719451
14	S-palmitoylation	RTLVHRYCAGEENWV HHHHHHHHCCCCCCC	3.85	19801377
40	Phosphorylation	PPPGAEAYIPQRYPD CCCCCCCCCCCCCCC	12.49	20736484
45	Phosphorylation	EAYIPQRYPDNRIVS CCCCCCCCCCCCEEC	15.08	20736484
137	Ubiquitination	VHFIQHGKLVRKQSR HHHHHCCHHHHHHCC	41.50	-
187	Phosphorylation	TASLDGESSHKTHYA EEECCCCCCCCCEEE	43.18	28857561
188	Phosphorylation	ASLDGESSHKTHYAV EECCCCCCCCCEEEE	25.38	28857561
257	Ubiquitination	LLRGATLKNTEKIFG EECCCCCCCHHHEEE	58.42	-
279	Phosphorylation	ETKMALNYQSKSQKR HHHHHHHCCCHHHHH	18.27	30622161
281	Phosphorylation	KMALNYQSKSQKRSA HHHHHCCCHHHHHHH	24.74	30622161
283	Phosphorylation	ALNYQSKSQKRSAVE HHHCCCHHHHHHHHH	46.29	29978859
285	Acetylation	NYQSKSQKRSAVEKS HCCCHHHHHHHHHHH	56.25	18585829
287	Phosphorylation	QSKSQKRSAVEKSMN CCHHHHHHHHHHHHH	43.64	19835603
292	Phosphorylation	KRSAVEKSMNAFLIV HHHHHHHHHHHHHHH	12.08	19835603
300	Phosphorylation	MNAFLIVYLCILISK HHHHHHHHHHHHHHH	6.72	19835603
306	Phosphorylation	VYLCILISKALINTV HHHHHHHHHHHHHHH	14.39	20068231
329	Phosphorylation	PFRDEPWYNQKTESE CCCCCCCCCCCCHHH	20.59	-
367	Phosphorylation	IPVSMYVTVEMQKFL CCHHHHHHHHHHHHH	8.02	20068231
436	Phosphorylation	CCIEGHVYVPHVICN HEEECEEEECEEEEC	11.55	-
459	Phosphorylation	GIDMIDSSPSVNGRE CCCCCCCCCCCCHHH	19.90	25159151
488	Phosphorylation	VQVKDDDSVDGPRKS EECCCCCCCCCCCCC	29.15	28787133
494	Ubiquitination	DSVDGPRKSPDGGKS CCCCCCCCCCCCCCC	70.27	-
495	Phosphorylation	SVDGPRKSPDGGKSC CCCCCCCCCCCCCCE	29.51	20873877
507	Phosphorylation	KSCVYISSSPDEVAL CCEEEECCCCHHHHH	36.01	-
529	Ubiquitination	GFTYLRLKDNYMEIL CCEEEEECHHHHHHH	37.18	21906983
561	Phosphorylation	DSVRRRMSVIVKSAT HHHHHHHEEEEECCC	13.59	25072903
566	Phosphorylation	RMSVIVKSATGEIYL HHEEEEECCCCCEEE	21.84	25072903
568	Phosphorylation	SVIVKSATGEIYLFC EEEEECCCCCEEEEE	42.30	25072903
572	Phosphorylation	KSATGEIYLFCKGAD ECCCCCEEEEECCCC	6.88	25072903
580	Phosphorylation	LFCKGADSSIFPRVI EEECCCCCCCCHHHH	25.46	25072903
581	Phosphorylation	FCKGADSSIFPRVIE EECCCCCCCCHHHHC	28.88	25072903
590	Ubiquitination	FPRVIEGKVDQIRAR CHHHHCCCHHHHHHH	29.83	21906983
614	Ubiquitination	RTLCVAYKRLIQEEY HHHHHHHHHHHHHHH	30.87	-
626	Ubiquitination	EEYEGICKLLQAAKV HHHHHHHHHHHHHHH	50.76	-
632	Ubiquitination	CKLLQAAKVALQDRE HHHHHHHHHHHHHHH	30.93	21890473
641	Ubiquitination	ALQDREKKLAEAYEQ HHHHHHHHHHHHHHH	48.45	-
651	Ubiquitination	EAYEQIEKDLTLLGA HHHHHHHHHHHHHCC	60.72	-
668	Ubiquitination	VEDRLQEKAADTIEA HHHHHHHHHHHHHHH	35.59	21906983
672	Phosphorylation	LQEKAADTIEALQKA HHHHHHHHHHHHHHC	18.91	27174698
678	Ubiquitination	DTIEALQKAGIKVWV HHHHHHHHCCCEEEE	49.81	21890473
702	Ubiquitination	AATCYACKLFRRNTQ HHHHHHHHHHHHCCH	42.35	21890473
708	Phosphorylation	CKLFRRNTQLLELTT HHHHHHCCHHHHHHH	20.84	21659604
714	Phosphorylation	NTQLLELTTKRIEEQ CCHHHHHHHHHHHHC	22.39	-
715	Phosphorylation	TQLLELTTKRIEEQS CHHHHHHHHHHHHCC	30.83	-
716	Ubiquitination	QLLELTTKRIEEQSL HHHHHHHHHHHHCCH	46.25	21890473
732	Ubiquitination	DVLFELSKTVLRHSG HHHHHHHHHHHHHCC	56.10	-
733	Phosphorylation	VLFELSKTVLRHSGS HHHHHHHHHHHHCCC	22.77	23663014
738	Phosphorylation	SKTVLRHSGSLTRDN HHHHHHHCCCCCCCC	24.52	10470851
740	Phosphorylation	TVLRHSGSLTRDNLS HHHHHCCCCCCCCCC	29.58	25159151
742	Phosphorylation	LRHSGSLTRDNLSGL HHHCCCCCCCCCCCC	37.36	23663014
747	Phosphorylation	SLTRDNLSGLSADMQ CCCCCCCCCCCCCHH	43.90	28857561
750	Phosphorylation	RDNLSGLSADMQDYG CCCCCCCCCCHHHHE	26.25	28857561
756	Phosphorylation	LSADMQDYGLIIDGA CCCCHHHHEEEEECH	9.28	28857561
766	Phosphorylation	IIDGAALSLIMKPRE EEECHHHHEEECCCC	15.89	28857561
776	Phosphorylation	MKPREDGSSGNYREL ECCCCCCCCCCHHHH	47.60	-
777	Phosphorylation	KPREDGSSGNYRELF CCCCCCCCCCHHHHH	36.27	-
780	Phosphorylation	EDGSSGNYRELFLEI CCCCCCCHHHHHHHH	14.69	-
809	Ubiquitination	LQKAQIVKLIKFSKE CCHHHHHHHHHHCCC	46.23	21890473
812	Ubiquitination	AQIVKLIKFSKEHPI HHHHHHHHHCCCCCE	54.76	-
854	Phosphorylation	GRQAARNSDYAIPKF HHHHHHCCCCCCCHH	26.84	27251275
949	Phosphorylation	DVLKRDPTLYRDVAK HHHCCCCCCHHHHHH	40.48	21815630

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AT11A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AT11A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AT11A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CC50A_HUMAN	TMEM30A	physical	21914794

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.