NEC1_HUMAN - dbPTM
NEC1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NEC1_HUMAN
UniProt AC P29120
Protein Name Neuroendocrine convertase 1
Gene Name PCSK1
Organism Homo sapiens (Human).
Sequence Length 753
Subcellular Localization Cytoplasmic vesicle, secretory vesicle. Localized in the secretion granules.
Protein Description Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP..
Protein Sequence MERRAWSLQCTAFVLFCAWCALNSAKAKRQFVNEWAAEIPGGPEAASAIAEELGYDLLGQIGSLENHYLFKHKNHPRRSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSALRDSALNLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALKANGEVIIEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIVNWKLILHGTSSQPEHMKQPRVYTSYNTVQNDRRGVEKMVDPGEEQPTQENPKENTLVSKSPSSSSVGGRRDELEEGAPSQAMLRLLQSAFSKNSPPKQSPKKSPSAKLNIPYENFYEALEKLNKPSQLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEEN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
79PhosphorylationHKNHPRRSRRSAFHI
CCCCCCHHHCCHHHH
33.0717081983
87PhosphorylationRRSAFHITKRLSDDD
HCCHHHHHHCCCCCC
11.09-
173N-linked_GlycosylationLDDGLEWNHTDIYAN
ECCCCCCCCCCEECC
20.85UniProtKB CARBOHYD
401N-linked_GlycosylationLALEANPNLTWRDMQ
HHHHCCCCCCHHHCC
50.32UniProtKB CARBOHYD
632O-linked_GlycosylationDPGEEQPTQENPKEN
CCCCCCCCCCCCCCC
48.4855830845
640O-linked_GlycosylationQENPKENTLVSKSPS
CCCCCCCCCCCCCCC
29.6355835819
643O-linked_GlycosylationPKENTLVSKSPSSSS
CCCCCCCCCCCCCCC
30.4555835823
649PhosphorylationVSKSPSSSSVGGRRD
CCCCCCCCCCCCCHH
33.1230631047
701PhosphorylationNIPYENFYEALEKLN
CCCHHHHHHHHHHCC
16.3327642862
711PhosphorylationLEKLNKPSQLKDSED
HHHCCCHHHCCCCCC
50.1629396449
719PhosphorylationQLKDSEDSLYNDYVD
HCCCCCCCCCHHHCH
28.8026503514
721PhosphorylationKDSEDSLYNDYVDVF
CCCCCCCCHHHCHHH
15.2226503514
729PhosphorylationNDYVDVFYNTKPYKH
HHHCHHHHCCCCCCC
23.0526503514

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NEC1_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NEC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NEC1_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ENV_HV1H2envphysical
8940009

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NEC1_HUMAN

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Related Literatures of Post-Translational Modification

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