UniProt ID | NEC1_HUMAN | |
---|---|---|
UniProt AC | P29120 | |
Protein Name | Neuroendocrine convertase 1 | |
Gene Name | PCSK1 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 753 | |
Subcellular Localization | Cytoplasmic vesicle, secretory vesicle. Localized in the secretion granules. | |
Protein Description | Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.. | |
Protein Sequence | MERRAWSLQCTAFVLFCAWCALNSAKAKRQFVNEWAAEIPGGPEAASAIAEELGYDLLGQIGSLENHYLFKHKNHPRRSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSALRDSALNLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALKANGEVIIEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIVNWKLILHGTSSQPEHMKQPRVYTSYNTVQNDRRGVEKMVDPGEEQPTQENPKENTLVSKSPSSSSVGGRRDELEEGAPSQAMLRLLQSAFSKNSPPKQSPKKSPSAKLNIPYENFYEALEKLNKPSQLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEEN | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
79 | Phosphorylation | HKNHPRRSRRSAFHI CCCCCCHHHCCHHHH | 33.07 | 17081983 | |
87 | Phosphorylation | RRSAFHITKRLSDDD HCCHHHHHHCCCCCC | 11.09 | - | |
173 | N-linked_Glycosylation | LDDGLEWNHTDIYAN ECCCCCCCCCCEECC | 20.85 | UniProtKB CARBOHYD | |
401 | N-linked_Glycosylation | LALEANPNLTWRDMQ HHHHCCCCCCHHHCC | 50.32 | UniProtKB CARBOHYD | |
632 | O-linked_Glycosylation | DPGEEQPTQENPKEN CCCCCCCCCCCCCCC | 48.48 | 55830845 | |
640 | O-linked_Glycosylation | QENPKENTLVSKSPS CCCCCCCCCCCCCCC | 29.63 | 55835819 | |
643 | O-linked_Glycosylation | PKENTLVSKSPSSSS CCCCCCCCCCCCCCC | 30.45 | 55835823 | |
649 | Phosphorylation | VSKSPSSSSVGGRRD CCCCCCCCCCCCCHH | 33.12 | 30631047 | |
701 | Phosphorylation | NIPYENFYEALEKLN CCCHHHHHHHHHHCC | 16.33 | 27642862 | |
711 | Phosphorylation | LEKLNKPSQLKDSED HHHCCCHHHCCCCCC | 50.16 | 29396449 | |
719 | Phosphorylation | QLKDSEDSLYNDYVD HCCCCCCCCCHHHCH | 28.80 | 26503514 | |
721 | Phosphorylation | KDSEDSLYNDYVDVF CCCCCCCCHHHCHHH | 15.22 | 26503514 | |
729 | Phosphorylation | NDYVDVFYNTKPYKH HHHCHHHHCCCCCCC | 23.05 | 26503514 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NEC1_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NEC1_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NEC1_HUMAN !! |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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