dbPTM

NEC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NEC1_HUMAN
UniProt AC	P29120
Protein Name	Neuroendocrine convertase 1
Gene Name	PCSK1
Organism	Homo sapiens (Human).
Sequence Length	753
Subcellular Localization	Cytoplasmic vesicle, secretory vesicle. Localized in the secretion granules.
Protein Description	Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP..
Protein Sequence	MERRAWSLQCTAFVLFCAWCALNSAKAKRQFVNEWAAEIPGGPEAASAIAEELGYDLLGQIGSLENHYLFKHKNHPRRSRRSAFHITKRLSDDDRVIWAEQQYEKERSKRSALRDSALNLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRSVPEKKECVVKDNDFEPRALKANGEVIIEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIVNWKLILHGTSSQPEHMKQPRVYTSYNTVQNDRRGVEKMVDPGEEQPTQENPKENTLVSKSPSSSSVGGRRDELEEGAPSQAMLRLLQSAFSKNSPPKQSPKKSPSAKLNIPYENFYEALEKLNKPSQLKDSEDSLYNDYVDVFYNTKPYKHRDDRLLQALVDILNEEN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Phosphorylation	HKNHPRRSRRSAFHI CCCCCCHHHCCHHHH	33.07	17081983
87	Phosphorylation	RRSAFHITKRLSDDD HCCHHHHHHCCCCCC	11.09	-
173	N-linked_Glycosylation	LDDGLEWNHTDIYAN ECCCCCCCCCCEECC	20.85	UniProtKB CARBOHYD
401	N-linked_Glycosylation	LALEANPNLTWRDMQ HHHHCCCCCCHHHCC	50.32	UniProtKB CARBOHYD
632	O-linked_Glycosylation	DPGEEQPTQENPKEN CCCCCCCCCCCCCCC	48.48	55830845
640	O-linked_Glycosylation	QENPKENTLVSKSPS CCCCCCCCCCCCCCC	29.63	55835819
643	O-linked_Glycosylation	PKENTLVSKSPSSSS CCCCCCCCCCCCCCC	30.45	55835823
649	Phosphorylation	VSKSPSSSSVGGRRD CCCCCCCCCCCCCHH	33.12	30631047
701	Phosphorylation	NIPYENFYEALEKLN CCCHHHHHHHHHHCC	16.33	27642862
711	Phosphorylation	LEKLNKPSQLKDSED HHHCCCHHHCCCCCC	50.16	29396449
719	Phosphorylation	QLKDSEDSLYNDYVD HCCCCCCCCCHHHCH	28.80	26503514
721	Phosphorylation	KDSEDSLYNDYVDVF CCCCCCCCHHHCHHH	15.22	26503514
729	Phosphorylation	NDYVDVFYNTKPYKH HHHCHHHHCCCCCCC	23.05	26503514

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NEC1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NEC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NEC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ENV_HV1H2	env	physical	8940009

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NEC1_HUMAN

Related Literatures of Post-Translational Modification