RAI2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAI2_HUMAN
• UniProt AC: Q9Y5P3
• Protein Name: Retinoic acid-induced protein 2
• Gene Name: RAI2
• Organism: Homo sapiens (Human).
• Sequence Length: 530
• Protein Sequence: MDDLQSQNLSMDMTDSPPALANNRLENGMAQLITTEAWNINSTDLVKKALVTVPAPSILNPPAESQSGMALKVAATVLQPLCLGESPVVMPIHMQVEGSSAPELNPNGNATYVMTTQGPVQLPVVLEQHVFQHLNSPLVLPQEAPCSSSTIHNNLFQGAEDPEAQPQLLDLRIPSQPQEPTLPFEAVLQNLFPSQGTLGPPPCQPPPGYAPVPPQPFSSPLSPLVPPATLLVPYPVIVPLPVPVPIPIPIPMPQSSESKFSSSFPKPPSSFGLHPFKGTQTPLEKDELKPFDILQPKEYFQLSRHTVIKMGSENEALDLSMKSVPWLKAGEVSPPIFQEDAALDLSVAAHRKSEPPPETLYDSGASVDSSGHTVMEKLPSGMEISFAPATSHEAPAMMDSHISSSDAATEMLSQPNHPSGEVKAENNIEMVGESQAAKVIVSVEDAVPTIFCGKIKGLSGVSTKNFSFKREDSVLQGYDINSQGEESMGNAEPLRKPIKNRSIKLKKVNSQEIHMLPIKKQRLATFFPRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	DLQSQNLSMDMTDSP HHHHCCCCCCCCCCC	21.93	27251275
14	Phosphorylation	QNLSMDMTDSPPALA CCCCCCCCCCCHHHH	29.12	27251275
16	Phosphorylation	LSMDMTDSPPALANN CCCCCCCCCHHHHCC	24.50	27251275
216	Ubiquitination	YAPVPPQPFSSPLSP CCCCCCCCCCCCCCC	36.54	21890473
266	Ubiquitination	KFSSSFPKPPSSFGL CCCCCCCCCCCCCCC	68.50	21890473
279	Phosphorylation	GLHPFKGTQTPLEKD CCCCCCCCCCCCCCC	29.84	27251275
281	Phosphorylation	HPFKGTQTPLEKDEL CCCCCCCCCCCCCCC	29.67	24719451
299	Phosphorylation	DILQPKEYFQLSRHT CCCCHHHHHHCCCCE	11.62	26074081
303	Phosphorylation	PKEYFQLSRHTVIKM HHHHHHCCCCEEEEC	15.95	26074081
306	Phosphorylation	YFQLSRHTVIKMGSE HHHCCCCEEEECCCC	23.86	26074081
312	Phosphorylation	HTVIKMGSENEALDL CEEEECCCCCHHHCH	33.48	26074081
320	Phosphorylation	ENEALDLSMKSVPWL CCHHHCHHHCCCCCH	24.67	27251275
333	Phosphorylation	WLKAGEVSPPIFQED CHHCCCCCCCCCCCC	22.21	26074081
346	Phosphorylation	EDAALDLSVAAHRKS CCHHHCHHHHHHCCC	14.91	26074081
353	Phosphorylation	SVAAHRKSEPPPETL HHHHHCCCCCCCCHH	56.12	26074081
456	Ubiquitination	TIFCGKIKGLSGVST EEECCCCCCCCCCCC	58.23	-
467	Phosphorylation	GVSTKNFSFKREDSV CCCCCCCCEECCCCE	38.97	24719451
473	Phosphorylation	FSFKREDSVLQGYDI CCEECCCCEECCEEC	21.70	24719451
478	Phosphorylation	EDSVLQGYDINSQGE CCCEECCEECCCCCC	10.73	26074081
482	Phosphorylation	LQGYDINSQGEESMG ECCEECCCCCCHHCC	39.64	26074081
487	Phosphorylation	INSQGEESMGNAEPL CCCCCCHHCCCCCCC	27.90	26074081
510	Phosphorylation	IKLKKVNSQEIHMLP EEEEECCCCEEEEEE	31.98	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAI2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAI2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAI2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SGTB_HUMAN	SGTB	physical	16189514
A4_HUMAN	APP	physical	21832049
SGTB_HUMAN	SGTB	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.