| UniProt ID | SCAI_HUMAN | |
|---|---|---|
| UniProt AC | Q8N9R8 | |
| Protein Name | Protein SCAI | |
| Gene Name | SCAI | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 606 | |
| Subcellular Localization |
Membrane Single-pass membrane protein . Nucleus . Cytoplasm . Nuclear localization is required for inhibition of MKL1.. |
|
| Protein Description | Tumor suppressor which functions to suppress MKL1-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1.. | |
| Protein Sequence | MVRGARQPQQPRSRLAPRLTGTVEKPPRKRRSRTEFALKEIMSSGGAEDDIPQGERKTVTDFCYLLDKSKQLFNGLRDLPQYGQKQWQSYFGRTFDVYTKLWKFQQQHRQVLDNRYGLKRWQIGEIASKIGQLYYHYYLRTSETSYLNEAFSFYSAIRQRSYYSQVNKEDRPELVVKKLRYYARFIVVCLLLNKMDVVKDLVKELSDEIEDYTHRFNTEDQVEWNLVLQEVAAFIEADPVMVLNDDNTIVITSNRLAETGAPLLEQGMIVGQLSLADALIIGNCNNQVKFSELTVDMFRMLQALEREPMNLASQMNKPGMQESADKPTRRENPHKYLLYKPTFSQLYTFLAASFKELPANSVLLIYLSATGVFPTGRSDSEGPYDFGGVLTNSNRDIINGDAIHKRNQSHKEMHCLHPGDLYPFTRKPLFIIVDSSNSVAYKNFTNLFGQPLVCLLSPTAYPKALQDQSQRGSLFTLFLNNPLMAFLFVSGLSSMRRGLWEKCQEYLRKINRDIAQLLTHSRSIDQAFLQFFGDEFLRLLLTRFIFCSATMRMHKIFRETRNYPESYPQLPRDETVENPHLQKHILELASILDVRNVFFENTIDDY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 13 | Phosphorylation | RQPQQPRSRLAPRLT CCCCCCHHCCCCCCC | 38.03 | 24719451 | |
| 20 | Phosphorylation | SRLAPRLTGTVEKPP HCCCCCCCCCCCCCC | 31.89 | 24719451 | |
| 22 | Phosphorylation | LAPRLTGTVEKPPRK CCCCCCCCCCCCCCC | 21.91 | - | |
| 25 | Acetylation | RLTGTVEKPPRKRRS CCCCCCCCCCCCCCC | 56.86 | 25953088 | |
| 32 (in isoform 2) | Phosphorylation | - | 47.81 | 28634120 | |
| 32 | Phosphorylation | KPPRKRRSRTEFALK CCCCCCCCCHHHHHH | 47.81 | 24719451 | |
| 33 (in isoform 2) | Phosphorylation | - | 36.14 | 25999147 | |
| 57 | Ubiquitination | DIPQGERKTVTDFCY CCCCCCCCCHHHHHH | 42.94 | - | |
| 64 | Phosphorylation | KTVTDFCYLLDKSKQ CCHHHHHHHHHHHHH | 15.42 | 21082442 | |
| 68 | Acetylation | DFCYLLDKSKQLFNG HHHHHHHHHHHHHHC | 60.57 | 25953088 | |
| 80 (in isoform 2) | Ubiquitination | - | 29.63 | - | |
| 91 (in isoform 2) | Ubiquitination | - | 6.90 | - | |
| 100 | Acetylation | RTFDVYTKLWKFQQQ CHHHHHHHHHHHHHH | 34.36 | 25953088 | |
| 100 | Ubiquitination | RTFDVYTKLWKFQQQ CHHHHHHHHHHHHHH | 34.36 | - | |
| 103 | Acetylation | DVYTKLWKFQQQHRQ HHHHHHHHHHHHHHH | 43.67 | 25953088 | |
| 103 | Malonylation | DVYTKLWKFQQQHRQ HHHHHHHHHHHHHHH | 43.67 | 26320211 | |
| 123 (in isoform 2) | Ubiquitination | - | 4.19 | - | |
| 181 | Phosphorylation | LVVKKLRYYARFIVV HHHHHHHHHHHHHHH | 16.35 | - | |
| 353 | Phosphorylation | LYTFLAASFKELPAN HHHHHHHHCCCCCCC | 31.11 | 24719451 | |
| 405 | Ubiquitination | INGDAIHKRNQSHKE CCCCHHHHCCCCCCC | 47.10 | - | |
| 422 | Phosphorylation | CLHPGDLYPFTRKPL CCCCCCCCCCCCCCE | 10.88 | - | |
| 428 (in isoform 2) | Ubiquitination | - | 29.25 | - | |
| 435 | Phosphorylation | PLFIIVDSSNSVAYK CEEEEECCCCCCCCC | 22.11 | 20068231 | |
| 436 | Phosphorylation | LFIIVDSSNSVAYKN EEEEECCCCCCCCCC | 28.76 | 20068231 | |
| 438 | Phosphorylation | IIVDSSNSVAYKNFT EEECCCCCCCCCCHH | 15.29 | 20068231 | |
| 441 | Phosphorylation | DSSNSVAYKNFTNLF CCCCCCCCCCHHHHC | 12.33 | 20068231 | |
| 473 | Phosphorylation | QDQSQRGSLFTLFLN HCHHHCCCHHHHHHC | 23.62 | 23401153 | |
| 490 | Phosphorylation | LMAFLFVSGLSSMRR HHHHHHHHCHHHHHC | 27.04 | 23401153 | |
| 493 | Phosphorylation | FLFVSGLSSMRRGLW HHHHHCHHHHHCHHH | 26.13 | 23401153 | |
| 494 | Phosphorylation | LFVSGLSSMRRGLWE HHHHCHHHHHCHHHH | 22.73 | 23401153 | |
| 548 | Phosphorylation | LTRFIFCSATMRMHK HHHHHHHHHHHHHHH | 18.94 | 27135362 | |
| 550 | Phosphorylation | RFIFCSATMRMHKIF HHHHHHHHHHHHHHH | 6.76 | 27135362 | |
| 606 | Phosphorylation | FENTIDDY------- HHCCCCCC------- | 19.39 | 28796482 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SCAI_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SCAI_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SCAI_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SCAI_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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