KHNYN_HUMAN - dbPTM
KHNYN_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KHNYN_HUMAN
UniProt AC O15037
Protein Name Protein KHNYN
Gene Name KHNYN
Organism Homo sapiens (Human).
Sequence Length 678
Subcellular Localization
Protein Description
Protein Sequence MPTWGARPASPDRFAVSAEAENKVREQQPHVERIFSVGVSVLPKDCPDNPHIWLQLEGPKENASRAKEYLKGLCSPELQDEIHYPPKLHCIFLGAQGFFLDCLAWSTSAHLVPRAPGSLMISGLTEAFVMAQSRVEELAERLSWDFTPGPSSGASQCTGVLRDFSALLQSPGDAHREALLQLPLAVQEELLSLVQEASSGQGPGALASWEGRSSALLGAQCQGVRAPPSDGRESLDTGSMGPGDCRGARGDTYAVEKEGGKQGGPREMDWGWKELPGEEAWEREVALRPQSVGGGARESAPLKGKALGKEEIALGGGGFCVHREPPGAHGSCHRAAQSRGASLLQRLHNGNASPPRVPSPPPAPEPPWHCGDRGDCGDRGDVGDRGDKQQGMARGRGPQWKRGARGGNLVTGTQRFKEALQDPFTLCLANVPGQPDLRHIVIDGSNVAMVHGLQHYFSSRGIAIAVQYFWDRGHRDITVFVPQWRFSKDAKVRESHFLQKLYSLSLLSLTPSRVMDGKRISSYDDRFMVKLAEETDGIIVSNDQFRDLAEESEKWMAIIRERLLPFTFVGNLFMVPDDPLGRNGPTLDEFLKKPARTQGSSKAQHPSRGFAEHGKQQQGREEEKGSGGIRKTRETERLRRQLLEVFWGQDHKVDFILQREPYCRDINQLSEALLSLNF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MPTWGARPAS
-----CCCCCCCCCC		34.9223927012
10PhosphorylationTWGARPASPDRFAVS
CCCCCCCCCCCEEEC		29.9823927012
17PhosphorylationSPDRFAVSAEAENKV
CCCCEEECHHHHHHH		19.5727050516
36PhosphorylationPHVERIFSVGVSVLP
CCHHHHEEECEEECC		18.6524247654
40PhosphorylationRIFSVGVSVLPKDCP
HHEEECEEECCCCCC		16.4125262027
51PhosphorylationKDCPDNPHIWLQLEG
CCCCCCCCEEEEEEC		30.0619651622
58PhosphorylationHIWLQLEGPKENASR
CEEEEEECCHHCHHH		47.36-
64UbiquitinationEGPKENASRAKEYLK
ECCHHCHHHHHHHHH		44.33-
101UbiquitinationGAQGFFLDCLAWSTS
ECCCCHHHHHHHHCC		21.89-
108UbiquitinationDCLAWSTSAHLVPRA
HHHHHHCCCCCCCCC		14.26-
112UbiquitinationWSTSAHLVPRAPGSL
HHCCCCCCCCCCCCE		1.85-
118PhosphorylationLVPRAPGSLMISGLT
CCCCCCCCEEEECHH		17.4420068231
122PhosphorylationAPGSLMISGLTEAFV
CCCCEEEECHHHHHH		17.4920068231
125PhosphorylationSLMISGLTEAFVMAQ
CEEEECHHHHHHHHH		28.8820068231
133PhosphorylationEAFVMAQSRVEELAE
HHHHHHHHHHHHHHH		28.8420068231
151PhosphorylationWDFTPGPSSGASQCT
CCCCCCCCCCHHHHC		47.5227251275
152PhosphorylationDFTPGPSSGASQCTG
CCCCCCCCCHHHHCH		41.3227251275
159PhosphorylationSGASQCTGVLRDFSA
CCHHHHCHHHHCHHH		24.8817081983
163PhosphorylationQCTGVLRDFSALLQS
HHCHHHHCHHHHHCC		37.3820068231
166PhosphorylationGVLRDFSALLQSPGD
HHHHCHHHHHCCCCH		16.5717081983
170PhosphorylationDFSALLQSPGDAHRE
CHHHHHCCCCHHHHH		30.7121712546
211PhosphorylationGALASWEGRSSALLG
CCCCEECCHHHHHHC		28.63-
213PhosphorylationLASWEGRSSALLGAQ
CCEECCHHHHHHCCC		30.7122210691
214PhosphorylationASWEGRSSALLGAQC
CEECCHHHHHHCCCC		22.9022210691
229PhosphorylationQGVRAPPSDGRESLD
CCCCCCCCCCCCCCC		52.1922210691
234PhosphorylationPPSDGRESLDTGSMG
CCCCCCCCCCCCCCC		30.1328985074
237PhosphorylationDGRESLDTGSMGPGD
CCCCCCCCCCCCCCC		36.1328348404
239PhosphorylationRESLDTGSMGPGDCR
CCCCCCCCCCCCCCC		23.7427470641
240SulfoxidationESLDTGSMGPGDCRG
CCCCCCCCCCCCCCC		8.7521406390
252PhosphorylationCRGARGDTYAVEKEG
CCCCCCCCEEEEECC		19.0628152594
253PhosphorylationRGARGDTYAVEKEGG
CCCCCCCEEEEECCC		17.2528270605
257UbiquitinationGDTYAVEKEGGKQGG
CCCEEEEECCCCCCC		55.87-
280PhosphorylationKELPGEEAWEREVAL
EECCCHHHHHHHEEC		14.77-
291PhosphorylationEVALRPQSVGGGARE
HEECCCCCCCCCCCC		25.9728985074
298UbiquitinationSVGGGARESAPLKGK
CCCCCCCCCCCCCCC		51.20-
299PhosphorylationVGGGARESAPLKGKA
CCCCCCCCCCCCCCC		29.6328555341
331PhosphorylationEPPGAHGSCHRAAQS
CCCCCCCHHHHHHHH		9.2528348404
332PhosphorylationPPGAHGSCHRAAQSR
CCCCCCHHHHHHHHH		2.74-
339MethylationCHRAAQSRGASLLQR
HHHHHHHHHHHHHHH		32.3954556993
342PhosphorylationAAQSRGASLLQRLHN
HHHHHHHHHHHHHHC		32.2223401153
350UbiquitinationLLQRLHNGNASPPRV
HHHHHHCCCCCCCCC		21.97-
353PhosphorylationRLHNGNASPPRVPSP
HHHCCCCCCCCCCCC		39.1623401153
359PhosphorylationASPPRVPSPPPAPEP
CCCCCCCCCCCCCCC		47.3723401153
372PhosphorylationEPPWHCGDRGDCGDR
CCCCCCCCCCCCCCC		57.70-
380MethylationRGDCGDRGDVGDRGD
CCCCCCCCCCCCCCH		38.40-
383PhosphorylationCGDRGDVGDRGDKQQ
CCCCCCCCCCCHHHH		24.52-
394PhosphorylationDKQQGMARGRGPQWK
HHHHHHCCCCCCHHC		26.8417081983
400PhosphorylationARGRGPQWKRGARGG
CCCCCCHHCCCCCCC		8.7517081983
405MethylationPQWKRGARGGNLVTG
CHHCCCCCCCCCCCC		57.2758858233
413PhosphorylationGGNLVTGTQRFKEAL
CCCCCCCHHHHHHHH		13.7528857561
417UbiquitinationVTGTQRFKEALQDPF
CCCHHHHHHHHCCCC		44.24-
417MethylationVTGTQRFKEALQDPF
CCCHHHHHHHHCCCC		44.24115971923
446MethylationHIVIDGSNVAMVHGL
EEEECCCCEEEEECH		30.97-
454PhosphorylationVAMVHGLQHYFSSRG
EEEEECHHHHHHHCC		33.55-
456PhosphorylationMVHGLQHYFSSRGIA
EEECHHHHHHHCCHH		7.6920090780
458MethylationHGLQHYFSSRGIAIA
ECHHHHHHHCCHHHH		16.38-
458PhosphorylationHGLQHYFSSRGIAIA
ECHHHHHHHCCHHHH		16.3828176486
458UbiquitinationHGLQHYFSSRGIAIA
ECHHHHHHHCCHHHH		16.38-
459PhosphorylationGLQHYFSSRGIAIAV
CHHHHHHHCCHHHHH		25.3228176486
495PhosphorylationKDAKVRESHFLQKLY
CCCCCCHHHHHHHHH		14.69-
497PhosphorylationAKVRESHFLQKLYSL
CCCCHHHHHHHHHHH		12.30-
502PhosphorylationSHFLQKLYSLSLLSL
HHHHHHHHHHHHHHC		18.0120090780
503PhosphorylationHFLQKLYSLSLLSLT
HHHHHHHHHHHHHCC		23.17-
505PhosphorylationLQKLYSLSLLSLTPS
HHHHHHHHHHHCCCC		22.71-
510PhosphorylationSLSLLSLTPSRVMDG
HHHHHHCCCCHHCCC		18.8220068231
523PhosphorylationDGKRISSYDDRFMVK
CCCCCCCCCCCHHHH		18.3128555341
526MethylationRISSYDDRFMVKLAE
CCCCCCCCHHHHHHH		20.75115480935
543PhosphorylationDGIIVSNDQFRDLAE
CCEEEECHHHHHHHH		41.30-
554UbiquitinationDLAEESEKWMAIIRE
HHHHHHHHHHHHHHH		52.1021890473
560MethylationEKWMAIIRERLLPFT
HHHHHHHHHHHCCEE		19.5024376655
560DimethylationEKWMAIIRERLLPFT
HHHHHHHHHHHCCEE		19.50-
567MethylationRERLLPFTFVGNLFM
HHHHCCEEEECCEEE		18.57-
571UbiquitinationLPFTFVGNLFMVPDD
CCEEEECCEEECCCC		25.46-
592UbiquitinationPTLDEFLKKPARTQG
CCHHHHHHCCHHCCC		63.13-
595UbiquitinationDEFLKKPARTQGSSK
HHHHHCCHHCCCCCC		35.71-
600PhosphorylationKPARTQGSSKAQHPS
CCHHCCCCCCCCCCC		20.88-
601PhosphorylationPARTQGSSKAQHPSR
CHHCCCCCCCCCCCC		38.54-
607PhosphorylationSSKAQHPSRGFAEHG
CCCCCCCCCCHHHCC		42.80-
615UbiquitinationRGFAEHGKQQQGREE
CCHHHCCCHHCCCCC		47.012190698
643UbiquitinationERLRRQLLEVFWGQD
HHHHHHHHHHHHCCC		3.90-
656UbiquitinationQDHKVDFILQREPYC
CCCCCEEEEECCCCC		2.50-
665UbiquitinationQREPYCRDINQLSEA
ECCCCCCCHHHHHHH		40.40-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KHNYN_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KHNYN_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KHNYN_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of KHNYN_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KHNYN_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118; THR-125; SER-353AND SER-359, AND MASS SPECTROMETRY.

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