| UniProt ID | G6PE_HUMAN | |
|---|---|---|
| UniProt AC | O95479 | |
| Protein Name | GDH/6PGL endoplasmic bifunctional protein | |
| Gene Name | H6PD | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 791 | |
| Subcellular Localization | Endoplasmic reticulum lumen. Microsomes, endoplasmic reticulum lumen. | |
| Protein Description | Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.. | |
| Protein Sequence | MWNMLIVAMCLALLGCLQAQELQGHVSIILLGATGDLAKKYLWQGLFQLYLDEAGRGHSFSFHGAALTAPKQGQELMAKALESLSCPKDMAPSHCAEHKDQFLQLSQYRQLKTAEDYQALNKDIEAQLQHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDHFSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRKALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRDVLQNHLTEVLTLVAMELPHNVSSAEAVLRHKLQVFQALRGLQRGSAVVGQYQSYSEQVRRELQKPDSFHSLTPTFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNQACCVQSEKHWAAAQSQCLPRQLVFHIGHGDLGSPAVLVSRNLFRPSLPSSWKEMEGPPGLRLFGSPLSDYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAHKAPRLYPGGAENGRLLDFEFSSGRLFFSQQQPEQLVPGPGPAPMPSDFQVLRAKYRESPLVSAWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHLLQHVRIPYYNIHPMPVHLQQRLCAEEDQGAQIYAREISALVANSSFDLVLLGMGADGHTASLFPQSPTGLDGEQLVVLTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLPHSGQLVWYMDYDAFLG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 20 | Pyrrolidone_carboxylic_acid | LLGCLQAQELQGHVS HHHHHHHHHHCCCEE | 38.68 | - | |
| 20 | Pyrrolidone_carboxylic_acid | LLGCLQAQELQGHVS HHHHHHHHHHCCCEE | 38.68 | - | |
| 83 | Phosphorylation | LMAKALESLSCPKDM HHHHHHHHCCCCCCC | 26.82 | 25072903 | |
| 85 | Phosphorylation | AKALESLSCPKDMAP HHHHHHCCCCCCCCH | 37.34 | 25072903 | |
| 106 | Phosphorylation | KDQFLQLSQYRQLKT HHHHHHHHHHHHCCC | 16.53 | 24043423 | |
| 108 | Phosphorylation | QFLQLSQYRQLKTAE HHHHHHHHHHCCCHH | 9.28 | 24043423 | |
| 117 | Phosphorylation | QLKTAEDYQALNKDI HCCCHHHHHHHHHHH | 6.28 | - | |
| 122 | Ubiquitination | EDYQALNKDIEAQLQ HHHHHHHHHHHHHHH | 62.02 | - | |
| 157 | N-linked_Glycosylation | EDIARNINSSCRPGP HHHHHHCCCCCCCCC | 31.27 | 19159218 | |
| 208 | Succinylation | RVDHYLGKQAVAQIL HHHHHCCHHHHHHHC | 32.27 | - | |
| 208 | Succinylation | RVDHYLGKQAVAQIL HHHHHCCHHHHHHHC | 32.27 | - | |
| 223 | Ubiquitination | PFRDQNRKALDGLWN CCCCCCHHHHHCHHH | 61.93 | - | |
| 251 | Phosphorylation | TVDAEGRTSFYEEYG ECCCCCCCCHHHHHH | 33.76 | 23403867 | |
| 257 | Phosphorylation | RTSFYEEYGVIRDVL CCCHHHHHHHHHHHH | 12.54 | 23403867 | |
| 282 | N-linked_Glycosylation | VAMELPHNVSSAEAV HHHHCCCCCCHHHHH | 33.17 | 19159218 | |
| 284 | Phosphorylation | MELPHNVSSAEAVLR HHCCCCCCHHHHHHH | 29.19 | 23403867 | |
| 285 | Phosphorylation | ELPHNVSSAEAVLRH HCCCCCCHHHHHHHH | 26.33 | 23403867 | |
| 301 | Methylation | LQVFQALRGLQRGSA HHHHHHHHHHHCCCC | 46.95 | - | |
| 305 | Methylation | QALRGLQRGSAVVGQ HHHHHHHCCCCHHHH | 46.18 | - | |
| 313 | Phosphorylation | GSAVVGQYQSYSEQV CCCHHHHHHCHHHHH | 8.10 | 28450419 | |
| 315 | Phosphorylation | AVVGQYQSYSEQVRR CHHHHHHCHHHHHHH | 26.20 | 28450419 | |
| 316 | Phosphorylation | VVGQYQSYSEQVRRE HHHHHHCHHHHHHHH | 10.74 | 17053785 | |
| 317 | Phosphorylation | VGQYQSYSEQVRREL HHHHHCHHHHHHHHH | 27.14 | 28450419 | |
| 358 | Phosphorylation | GVPFILMSGKALDER CCCEEEECCCHHHHH | 33.43 | 24719451 | |
| 409 | Phosphorylation | IGHGDLGSPAVLVSR ECCCCCCCCEEEEEC | 19.58 | - | |
| 426 | Phosphorylation | FRPSLPSSWKEMEGP CCCCCCCCHHHCCCC | 39.98 | - | |
| 449 | Phosphorylation | PLSDYYAYSPVRERD CHHHCCCCCCCCCCC | 9.44 | - | |
| 450 | Phosphorylation | LSDYYAYSPVRERDA HHHCCCCCCCCCCCC | 14.56 | - | |
| 683 | N-linked_Glycosylation | EISALVANSSFDLVL HHHHHHHCCCCCEEE | 30.61 | UniProtKB CARBOHYD | |
| 730 | Phosphorylation | SQPHRRMSLSLPLIN CCCCCCCCCCHHHHH | 17.00 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of G6PE_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of G6PE_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of G6PE_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of G6PE_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| OMIM Disease | ||||||
| 604931 | Cortisone reductase deficiency (CRD) | |||||
| Kegg Drug | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| N-linked Glycosylation | |
| Reference | PubMed |
| "Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-157 AND ASN-282, AND MASSSPECTROMETRY. | |
| Phosphorylation | |
| Reference | PubMed |
| "Tyrosine phosphorylated Par3 regulates epithelial tight junctionassembly promoted by EGFR signaling."; Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A.,Lottspeich F., Chen Z.; EMBO J. 25:5058-5070(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-316, AND MASSSPECTROMETRY. | |
