ADA11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADA11_HUMAN
• UniProt AC: O75078
• Protein Name: Disintegrin and metalloproteinase domain-containing protein 11
• Gene Name: ADAM11
• Organism: Homo sapiens (Human).
• Sequence Length: 769
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein..
• Protein Sequence: MRLLRRWAFAALLLSLLPTPGLGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGTTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGCREPGCLFAVPAQSAPPNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRREGLPEPSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEYGNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDTGFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQVLWGHAAADRFCYEKLNVEGTERGSCGRKGSGWVQCSKQDVLCGFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGSDLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLPTSPPTGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGFKNIRRGRSGGA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	LLLSLLPTPGLGTQG HHHHHCCCCCCCCCC	29.92	26853621
24	Phosphorylation	LPTPGLGTQGPAGAL CCCCCCCCCCCHHCH	35.08	46159007
51	Phosphorylation	APEVTEPSRLVRESS CCCCCCHHHHEECCC	31.82	17081983
57	Phosphorylation	PSRLVRESSGGEVRK HHHHEECCCCCCHHH	24.58	10400567
58	Phosphorylation	SRLVRESSGGEVRKQ HHHEECCCCCCHHHH	46.17	10400577
96	N-linked_Glycosylation	VIPAFNSNFTLDLEL EEECCCCCEEEEEEE	34.72	UniProtKB CARBOHYD
163	N-linked_Glycosylation	HGVFSDGNLTYIVEP EEECCCCCEEEEECC	33.91	UniProtKB CARBOHYD
308	Phosphorylation	VQDDLLETLARLMVY CCHHHHHHHHHHHHH	26.20	20058876
331	Phosphorylation	SDATHLFSGRTFQST CCCCCEECCCEEEEC	33.45	24719451
586	Phosphorylation	GSCGRKGSGWVQCSK CCCCCCCCCCEECCC	32.30	29759185
592	Phosphorylation	GSGWVQCSKQDVLCG CCCCEECCCCCEEEE	19.09	29759185
605	N-linked_Glycosylation	CGFLLCVNISGAPRL EEEEEEEECCCCCCH	23.01	UniProtKB CARBOHYD
673	N-linked_Glycosylation	CLPASAFNFSTCPGS EEECHHHCCCCCCCC	29.67	UniProtKB CARBOHYD
687	Phosphorylation	SGERRICSHHGVCSN CCCCEEECCCCEECC	19.02	23663014
693	Phosphorylation	CSHHGVCSNEGKCIC ECCCCEECCCCEEEE	35.19	23663014
739	Phosphorylation	GTNIIIGSIAGAVLV CCCEEEHHHHHHHHH	10.00	46159001

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADA11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADA11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADA11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STC2_HUMAN	STC2	physical	16169070

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.