CAH11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAH11_HUMAN
• UniProt AC: O75493
• Protein Name: Carbonic anhydrase-related protein 11
• Gene Name: CA11
• Organism: Homo sapiens (Human).
• Sequence Length: 328
• Subcellular Localization: Secreted .
• Protein Description: Does not have a catalytic activity..
• Protein Sequence: MGAAARLSAPRALVLWAALGAAAHIGPAPDPEDWWSYKDNLQGNFVPGPPFWGLVNAAWSLCAVGKRQSPVDVELKRVLYDPFLPPLRLSTGGEKLRGTLYNTGRHVSFLPAPRPVVNVSGGPLLYSHRLSELRLLFGARDGAGSEHQINHQGFSAEVQLIHFNQELYGNFSAASRGPNGLAILSLFVNVASTSNPFLSRLLNRDTITRISYKNDAYFLQDLSLELLFPESFGFITYQGSLSTPPCSETVTWILIDRALNITSLQMHSLRLLSQNPPSQIFQSLSGNSRPLQPLAHRALRGNRDPRHPERRCRGPNYRLHVDGVPHGR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MGAAARLSAPRALVL CCHHHHCCHHHHHHH	30.58	24719451
118	N-linked_Glycosylation	PAPRPVVNVSGGPLL CCCCCEEEECCCCEE	23.59	16335952
131	Phosphorylation	LLYSHRLSELRLLFG EEEECCHHHHHHHHC	34.24	29496963
170	N-linked_Glycosylation	FNQELYGNFSAASRG CCHHHHCCCCHHHCC	17.72	UniProtKB CARBOHYD
260	N-linked_Glycosylation	ILIDRALNITSLQMH HHHHCCCCCHHHHHH	34.21	UniProtKB CARBOHYD
328	Dimethylation	VDGVPHGR------- ECCCCCCC-------	40.09	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAH11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAH11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAH11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BIRC6_HUMAN	BIRC6	physical	26186194
P20D2_HUMAN	PM20D2	physical	26186194

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00909: Zonisamide

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-118, AND MASSSPECTROMETRY.
PubMed: 16335952