HYAL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HYAL2_HUMAN
• UniProt AC: Q12891
• Protein Name: Hyaluronidase-2
• Gene Name: HYAL2
• Organism: Homo sapiens (Human).
• Sequence Length: 473
• Subcellular Localization: Cell membrane ; Lipid-anchor, GPI-anchor .
• Protein Description: Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R..
• Protein Sequence: MRAGPGPTVTLALVLAVSWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAFDVQASPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYNHDYVQNWESYTGRCPDVEVARNDQLAWLWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTYSRRLTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNVSWATQYCSRAQCHGHGRCVRRNPSASTFLHLSTNSFRLVPGHAPGEPQLRPVGELSWADIDHLQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALAFTWTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	O-linked_Glycosylation	PTAPPIFTGRPFVVA CCCCCCCCCCCEEEE	32.76	OGP
74	N-linked_Glycosylation	NEGFVNQNITIFYRD CCCCCCCCEEEEEEC	28.32	UniProtKB CARBOHYD
103	N-linked_Glycosylation	VHGGVPQNVSLWAHR CCCCCCCCCHHHHHH	21.19	UniProtKB CARBOHYD
148	Ubiquitination	WVRNWQDKDVYRRLS EEECCCCHHHHHHHH	33.71	-
190	Phosphorylation	AQQFMLETLRYVKAV HHHHHHHHHHHHHHH	16.75	-
216	Phosphorylation	PDCYNHDYVQNWESY CCCCCCHHHCCHHHH	9.07	-
291	Phosphorylation	ANHALPVYVFTRPTY CCCCCEEEEEECCCC	6.47	-
297	Phosphorylation	VYVFTRPTYSRRLTG EEEEECCCCHHHCCC	30.73	-
298	Phosphorylation	YVFTRPTYSRRLTGL EEEECCCCHHHCCCC	11.67	-
303	Phosphorylation	PTYSRRLTGLSEMDL CCCHHHCCCCCHHHH	33.98	26307563
306	Phosphorylation	SRRLTGLSEMDLIST HHHCCCCCHHHHHHH	32.02	26307563
312	Phosphorylation	LSEMDLISTIGESAA CCHHHHHHHHHHHHH	22.67	26307563
313	Phosphorylation	SEMDLISTIGESAAL CHHHHHHHHHHHHHH	26.47	26307563
317	Phosphorylation	LISTIGESAALGAAG HHHHHHHHHHHCCCE	17.39	26307563
333	Phosphorylation	ILWGDAGYTTSTETC EEECCCCCCCCHHHH	14.47	26307563
334	Phosphorylation	LWGDAGYTTSTETCQ EECCCCCCCCHHHHH	17.22	26307563
335	Phosphorylation	WGDAGYTTSTETCQY ECCCCCCCCHHHHHH	25.76	26307563
336	Phosphorylation	GDAGYTTSTETCQYL CCCCCCCCHHHHHHH	19.22	26307563
337	Phosphorylation	DAGYTTSTETCQYLK CCCCCCCHHHHHHHH	32.97	26307563
339	Phosphorylation	GYTTSTETCQYLKDY CCCCCHHHHHHHHHH	12.66	26307563
342	Phosphorylation	TSTETCQYLKDYLTR CCHHHHHHHHHHHHH	20.19	26307563
357	N-linked_Glycosylation	LLVPYVVNVSWATQY HHHHEECCHHHHHHH	16.44	UniProtKB CARBOHYD
385	Phosphorylation	RRNPSASTFLHLSTN CCCCCCCCEEEECCC	29.90	24719451
391	Phosphorylation	STFLHLSTNSFRLVP CCEEEECCCCEECCC	41.04	24719451
448	GPI-anchor	DHRQAAGGASEAWAG CHHHHCCCCCHHHHH	22.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HYAL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HYAL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HYAL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KRA32_HUMAN	KRTAP3-2	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
PON2_HUMAN	PON2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.