VWDE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VWDE_HUMAN
• UniProt AC: Q8N2E2
• Protein Name: von Willebrand factor D and EGF domain-containing protein
• Gene Name: VWDE
• Organism: Homo sapiens (Human).
• Sequence Length: 1590
• Subcellular Localization: Secreted .
• Protein Sequence: MPGGACVLVIALMFLAWGEAQECSPGGHQFLRSPYRSVRFDSWHLQQSAVQDLICDHSLSPGWYRFLILDRPAEMPTKCVEMNHCGTQAPIWLSLRDSETLPSPGEIKQLTACATWQFLFSTTKDCCLFQIPVSVRNCGNFSVYLLQPTQGCMGYCAEAISDARLHPCGSDETETGGDCVRQLAASLPPPPAGRPEVLVELIESRLFCRCSFDVPATKNSVGFHIAWSRLSSQEVKEELTQETTVQAFSLLELDGINLRLGDRIFCSASVFFLENPHVQSVAIESQEFFAGFKLQPELSTISEDGKEYYLRIESTVPIICSEFSELDQECKISLKLKTIGQGREHLGLNLALSSCHVDLLQTSSCANGTCSHTFVYYTAVTDFSRDGDRVSNIVVQPIVNEDFLWNNYIPDSIQIKVKDVPTAYCYTFTDPHIITFDGRVYDNFKTGTFVLYKSMSRDFEVHVRQWDCRSLHYPVSCNCGFVAQEGGDIVTFDMCNGQLRESQPYLFIKSQDVTRNIKISESYLGRKVTIWFSSGAFIRADLGEWGMSLTIRAPSVDYRNTLGLCGTFDENPENDFHDKNGMQIDQNFNNYVAFINEWRILPGKSMSDTLPVSMTSPGKPSYCSCSLDTAAYPSSEDLDSVSRSEIALGCKDLNHVSLSSLIPELDVTSEYINSDTLVREINKHTSPEEYNLNLFLQEKKHINLTKLGLNVQKHPGNEKEDSLQYLANKKYTQGRGSHSQEMRYNRQNRWKRQNFHEFPPLFAFPSLSQTDLEELTYFFPEDHAEDVQQEFFPSWPTPSGLTEYSTLTLCQETLANSSIGRLCLAFLGKRLDSVIEMCVKDVLLKDDLSWAEAGVALLENECEKRIVEEGKYNTEEYGTSIEDILSVLKCPNLCSGNGQCMEWGCACSPSFSSYDCSDSYDKAPEITELGNAGFCDVQKYNCMMVRVFGKGFKELPSIKCEVTKLQYNSSEWMPGEPIYTQTVFHNSRAVDCQLPTDVQQFDTMDLVGGKPTGKWQLKVSNDGYKFSNPKITVIYDGACQVCGLYKNDSCTIKENVCIIDGLCYVEGDKNPTSPCLICRPKISRFTWSFLENNQPPVIQALQDKLQTFYGENFEYQFVAFDPEGSDIHFTLDSGPEGASVSSAGLFMWKTDLLTTQQITVRLNDDCDAETRVTIEVTVKSCDCLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDISGCQSNPCGLGSYISGFHSYSCDCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRKRHVKPTSGNAFTICKYPCGKSRECVAPNICKCKPGYIGSNCQTALCDPDCKNHGKCIKPNICQCLPGHGGATCDEEHCNPPCQHGGTCLAGNLCTCPYGFVGPRCETMVCNRHCENGGQCLTPDICQCKPGWYGPTCSTALCDPVCLNGGSCNKPNTCLCPNGFFGEHCQNAFCHPPCKNGGHCMRNNVCVCREGYTGRRFQKSICDPTCMNGGKCVGPSTCSCPSGWSGKRCNTPICLQKCKNGGECIAPSICHCPSSWEGVRCQIPICNPKCLYGGRCIFPNVCSCRTEYSGVKCEKKIQIRRH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
173	Phosphorylation	HPCGSDETETGGDCV CCCCCCCCCCCHHHH	43.78	26074081
175	Phosphorylation	CGSDETETGGDCVRQ CCCCCCCCCHHHHHH	54.61	26074081
186	Phosphorylation	CVRQLAASLPPPPAG HHHHHHHCCCCCCCC	35.48	26074081
220	Phosphorylation	DVPATKNSVGFHIAW CCCCCCCCEEEEEEH	25.77	28842319
228	Phosphorylation	VGFHIAWSRLSSQEV EEEEEEHHHCCCHHH	17.83	28842319
249	Phosphorylation	ETTVQAFSLLELDGI HHHHHHHHHEECCCC	34.75	-
367	N-linked_Glycosylation	LQTSSCANGTCSHTF EECCCCCCCCCCEEE	51.11	UniProtKB CARBOHYD
685	Phosphorylation	VREINKHTSPEEYNL HHHHHCCCCHHHHCH	47.81	24275569
703	N-linked_Glycosylation	LQEKKHINLTKLGLN HHCCCCCCCEECCEE	41.18	UniProtKB CARBOHYD
731	Phosphorylation	QYLANKKYTQGRGSH HHHHCCCCCCCCCCC	13.10	-
737	Phosphorylation	KYTQGRGSHSQEMRY CCCCCCCCCCHHHHH	20.71	-
840	Ubiquitination	SVIEMCVKDVLLKDD HHHHHHHHHHHCCCC	36.87	-
957	Phosphorylation	KGFKELPSIKCEVTK CCHHHCCCCEEEEEE	47.51	24719451
968	N-linked_Glycosylation	EVTKLQYNSSEWMPG EEEECEECCCCCCCC	26.54	UniProtKB CARBOHYD
1035	Phosphorylation	NPKITVIYDGACQVC CCEEEEEECCCCCEE	12.18	-
1045	Phosphorylation	ACQVCGLYKNDSCTI CCCEECCCCCCCCEE	7.95	-
1159	Phosphorylation	LLTTQQITVRLNDDC CCCCCEEEEECCCCC	8.67	23312004
1507	Phosphorylation	CVGPSTCSCPSGWSG EECCCCCCCCCCCCC	29.20	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VWDE_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VWDE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VWDE_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of VWDE_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.