dbPTM

ATS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ATS2_HUMAN
UniProt AC	O95450
Protein Name	A disintegrin and metalloproteinase with thrombospondin motifs 2
Gene Name	ADAMTS2
Organism	Homo sapiens (Human).
Sequence Length	1211
Subcellular Localization	Secreted, extracellular space, extracellular matrix.
Protein Description	Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis..
Protein Sequence	MDPPAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAVPVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVEWEYRDEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEERPETARTCRLGPCPRNISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPGYNKLCCKSCNLYNNLTNVEGRIEPPPGKHNDIDVFMPTLPVPTVAMEVRPSPSTPLEVPLNASSTNATEDHPETNAVDEPYKIHGLEDEVQPPNLIPRRPSPYEKTRNQRIQELIDEMRKKEMLGKF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
64	O-linked_Glycosylation	ILAVPVRTDAQGRLV EEEEEECCCCCCCCH	35.60	55828415
72	Phosphorylation	DAQGRLVSHVVSAAT CCCCCCHHHHHHHHH	18.37	22210691
112	N-linked_Glycosylation	PGSHLFYNVTVFGRD CCCEEEEEEEEECCE	18.69	UniProtKB CARBOHYD
238	Phosphorylation	ASLDSLDSLSRALGV CCHHHHHHHHHHHHH	33.27	26437602
240	Phosphorylation	LDSLDSLSRALGVLE HHHHHHHHHHHHHHH	21.32	22673903
251	N-linked_Glycosylation	GVLEEHANSSRRRAR HHHHHHHHHHHHHHH	42.28	UniProtKB CARBOHYD
524	Phosphorylation	CSHPDNPYFCKTKKG CCCCCCCCCCCCCCC	28.06	-
528	Phosphorylation	DNPYFCKTKKGPPLD CCCCCCCCCCCCCCC	38.89	30631047
537	Phosphorylation	KGPPLDGTMCAPGKH CCCCCCCCEECCCCC	14.56	46159313
658	Phosphorylation	AKERCHLYCESRETG HHHHCEEEECCCCCC	3.15	68731757
661	Phosphorylation	RCHLYCESRETGEVV HCEEEECCCCCCCEE	31.68	68731763
664	Phosphorylation	LYCESRETGEVVSMK EEECCCCCCCEEEEE	37.22	68731769
669	Phosphorylation	RETGEVVSMKRMVHD CCCCCEEEEEEEEEC	24.62	27251275
682	Phosphorylation	HDGTRCSYKDAFSLC ECCCCCCHHHHHHHH	19.26	7332591
687	Phosphorylation	CSYKDAFSLCVRGDC CCHHHHHHHHHCCCC	23.68	24719451
720	Phosphorylation	GVCGGDNSHCKVVKG CCCCCCCCCCEEEEE	34.69	46159307
899	Phosphorylation	RGFCAALSKPKAIRR CCHHHHHCCHHHHHH	42.03	24719451
949	N-linked_Glycosylation	CIQPLHDNTTRSVHA EECCCCCCCCCEEEH	32.38	UniProtKB CARBOHYD
953	Phosphorylation	LHDNTTRSVHAKHCN CCCCCCCEEEHHHCC	19.03	27174698
993	N-linked_Glycosylation	QCSVTCGNGTQERPV HCEEECCCCCCCCCE	53.11	UniProtKB CARBOHYD
1031	N-linked_Glycosylation	RLGPCPRNISDPSKK CCCCCCCCCCCCCCC	24.21	UniProtKB CARBOHYD
1098	N-linked_Glycosylation	KSCNLYNNLTNVEGR HHCCCCCCCCCCCCC	34.38	UniProtKB CARBOHYD
1127	O-linked_Glycosylation	MPTLPVPTVAMEVRP ECCCCCCEEEEEECC	22.56	OGP
1145	N-linked_Glycosylation	TPLEVPLNASSTNAT CCCEEECCCCCCCCC	31.54	UniProtKB CARBOHYD
1150	N-linked_Glycosylation	PLNASSTNATEDHPE ECCCCCCCCCCCCCC	46.98	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ATS2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ATS2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ATS2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ATS2_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ATS2_HUMAN

Related Literatures of Post-Translational Modification