LACC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LACC1_HUMAN
• UniProt AC: Q8IV20
• Protein Name: Laccase domain-containing protein 1
• Gene Name: LACC1 {ECO:0000303|PubMed:25220867, ECO:0000312|HGNC:HGNC:26789}
• Organism: Homo sapiens (Human).
• Sequence Length: 430
• Subcellular Localization: Peroxisome .
• Protein Description: Central regulator of the metabolic function and bioenergetic state of macrophages. In macrophages, promotes flux through de novo lipogenesis to concomitantly drive high levels of both fatty-acid oxidation and glycolysis..
• Protein Sequence: MAEAVLIDLFGLKLNSQKNCHQTLLKTLNAVQYHHAAKAKFLCIMCCSNISYERDGEQDNCEIETSNGLSALLEEFEIVSCPSMAATLYTIKQKIDEKNLSSIKVIVPRHRKTLMKAFIDQLFTDVYNFEFEDLQVTFRGGLFKQSIEINVITAQELRGIQNEIETFLRSLPALRGKLTIITSSLIPDIFIHGFTTRTGGISYIPTLSSFNLFSSSKRRDPKVVVQENLRRLANAAGFNVEKFYRIKTHHSNDIWIMGRKEPDSYDGITTNQRGVTIAALGADCIPIVFADPVKKACGVAHAGWKGTLLGVAMATVNAMIAEYGCSLEDIVVVLGPSVGPCCFTLPRESAEAFHNLHPACVQLFDSPNPCIDIRKATRILLEQGGILPQNIQDQNQDLNLCTSCHPDKFFSHVRDGLNFGTQIGFISIKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Ubiquitination	GLKLNSQKNCHQTLL CCCCCCCCCHHHHHH	62.45	29967540
101	Phosphorylation	KIDEKNLSSIKVIVP HCCCCCCCCCEEEEH	39.14	24719451
166	Phosphorylation	GIQNEIETFLRSLPA HHHHHHHHHHHHCHH	33.36	-
170	Phosphorylation	EIETFLRSLPALRGK HHHHHHHHCHHHCCC	40.63	30108239
206	Phosphorylation	GGISYIPTLSSFNLF CCCCEECCCCCCCCC	29.70	22210691
208	Phosphorylation	ISYIPTLSSFNLFSS CCEECCCCCCCCCCC	35.05	22210691
209	Phosphorylation	SYIPTLSSFNLFSSS CEECCCCCCCCCCCC	22.67	22210691
247	Acetylation	VEKFYRIKTHHSNDI HHHEEEEEECCCCCE	32.57	10730435
260	Ubiquitination	DIWIMGRKEPDSYDG CEEEECCCCCCCCCC	68.79	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LACC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LACC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
247	Acetylation	254 (7)	I ⇒ V	rs3764147	Crohn's disease	28067908 18587394 20018961 23128233 26192919

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIN3A_HUMAN	SIN3A	physical	26186194
NUFP2_HUMAN	NUFIP2	physical	26186194
ARI4B_HUMAN	ARID4B	physical	26186194
GPTC8_HUMAN	GPATCH8	physical	26186194
BRM1L_HUMAN	BRMS1L	physical	26186194
OSER1_HUMAN	OSER1	physical	26186194
HPHL1_HUMAN	HEPHL1	physical	26186194
TSNAX_HUMAN	TSNAX	physical	26186194
SPB5_HUMAN	SERPINB5	physical	26186194
PP2AA_HUMAN	PPP2CA	physical	26186194
SDS3_HUMAN	SUDS3	physical	26186194
PKP3_HUMAN	PKP3	physical	26186194
ALMS1_HUMAN	ALMS1	physical	26186194
SBP1_HUMAN	SELENBP1	physical	26186194
DUS14_HUMAN	DUSP14	physical	26186194
LRC15_HUMAN	LRRC15	physical	26186194
CKS2_HUMAN	CKS2	physical	26186194
DSG4_HUMAN	DSG4	physical	26186194
ZBT10_HUMAN	ZBTB10	physical	26186194
H2A2C_HUMAN	HIST2H2AC	physical	26186194
ATG9B_HUMAN	ATG9B	physical	26186194
PLP2_HUMAN	PLP2	physical	26186194
H2A2C_HUMAN	HIST2H2AC	physical	28514442
TSNAX_HUMAN	TSNAX	physical	28514442
DUS14_HUMAN	DUSP14	physical	28514442
BRM1L_HUMAN	BRMS1L	physical	28514442
SDS3_HUMAN	SUDS3	physical	28514442
CKS2_HUMAN	CKS2	physical	28514442
ZBT10_HUMAN	ZBTB10	physical	28514442
DSG4_HUMAN	DSG4	physical	28514442
PKP3_HUMAN	PKP3	physical	28514442
FA26D_HUMAN	FAM26D	physical	28514442
HPHL1_HUMAN	HEPHL1	physical	28514442
GPTC8_HUMAN	GPATCH8	physical	28514442
LYG2_HUMAN	LYG2	physical	28514442
LRC15_HUMAN	LRRC15	physical	28514442
SBP1_HUMAN	SELENBP1	physical	28514442
ARI4B_HUMAN	ARID4B	physical	28514442
SIN3A_HUMAN	SIN3A	physical	28514442
SPB5_HUMAN	SERPINB5	physical	28514442
ATG9B_HUMAN	ATG9B	physical	28514442
PLP2_HUMAN	PLP2	physical	28514442
PPAP_HUMAN	ACPP	physical	28514442
ALMS1_HUMAN	ALMS1	physical	28514442
PGFRB_HUMAN	PDGFRB	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.