NJMU_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NJMU_HUMAN
• UniProt AC: Q9HAS0
• Protein Name: Protein Njmu-R1
• Gene Name: C17orf75
• Organism: Homo sapiens (Human).
• Sequence Length: 396
• Protein Description: May have a role in spermatogenesis..
• Protein Sequence: MLPSLQESMDGDEKELESSEEGGSAEERRLEPPSSSHYCLYSYRGSRLAQQRGDSEDGSPSGTNAETPSGDDFSLSLADTNLPSEVEPELRSFIAKRLSRGAVFEGLGNVASVELKIPGYRVGCYYCLFQNEKLLPETVTIDSERNPSEYVVCFLGGSEKGLELFRLELDKYIQGLKNNMNCEARGLESHIKSYLSSWFEDVVCPIQRVVLLFQEKLTFLLHAALSYTPVEVKESDEKTKRDINRFLSVASLQGLIHEGTMTSLCMAMTEEQHKSVVIDCSSSQPQFCNAGSNRFCEDWMQAFLNGAKGGNPFLFRQVLENFKLKAIQDTNNLKRFIRQAEMNHYALFKCYMFLKNCGSGDILLKIVKVEHEEMPEAKNVIAVLEEFMKEALDQSF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MLPSLQESMDG ----CCCCHHHHCCC	38.43	29978859
8	Phosphorylation	MLPSLQESMDGDEKE CCCCHHHHCCCCHHH	14.82	25159151
18	Phosphorylation	GDEKELESSEEGGSA CCHHHHHCCCCCCCH	56.53	23401153
19	Phosphorylation	DEKELESSEEGGSAE CHHHHHCCCCCCCHH	30.23	30278072
24	Phosphorylation	ESSEEGGSAEERRLE HCCCCCCCHHHHCCC	43.28	23927012
42	Phosphorylation	SSHYCLYSYRGSRLA CCCEEEEEECCCHHH	8.73	24719451
43	Phosphorylation	SHYCLYSYRGSRLAQ CCEEEEEECCCHHHH	12.87	22817900
55	Phosphorylation	LAQQRGDSEDGSPSG HHHHHCCCCCCCCCC	40.17	30278072
59	Phosphorylation	RGDSEDGSPSGTNAE HCCCCCCCCCCCCCC	28.37	26657352
61	Phosphorylation	DSEDGSPSGTNAETP CCCCCCCCCCCCCCC	61.01	29523821
63	Phosphorylation	EDGSPSGTNAETPSG CCCCCCCCCCCCCCC	35.28	30278072
67	Phosphorylation	PSGTNAETPSGDDFS CCCCCCCCCCCCCCE	21.97	29116813
69	Phosphorylation	GTNAETPSGDDFSLS CCCCCCCCCCCCEEE	63.37	29116813
74	Phosphorylation	TPSGDDFSLSLADTN CCCCCCCEEEECCCC	24.84	29496963
76	Phosphorylation	SGDDFSLSLADTNLP CCCCCEEEECCCCCC	21.95	28102081
80	Phosphorylation	FSLSLADTNLPSEVE CEEEECCCCCCCCCC	32.80	28102081
92	Phosphorylation	EVEPELRSFIAKRLS CCCHHHHHHHHHHHH	33.36	24719451
99	Phosphorylation	SFIAKRLSRGAVFEG HHHHHHHHCCCCEEC	32.47	29514088
138	Phosphorylation	NEKLLPETVTIDSER CCCCCCCEEEECCCC	22.47	-
140	Phosphorylation	KLLPETVTIDSERNP CCCCCEEEECCCCCH	26.87	-
148	Phosphorylation	IDSERNPSEYVVCFL ECCCCCHHCEEEEEE	45.14	-
171	Ubiquitination	LFRLELDKYIQGLKN HHHHHHHHHHHHHHH	57.80	-
171	Acetylation	LFRLELDKYIQGLKN HHHHHHHHHHHHHHH	57.80	20167786
172	Phosphorylation	FRLELDKYIQGLKNN HHHHHHHHHHHHHHC	9.72	26074081
177	Ubiquitination	DKYIQGLKNNMNCEA HHHHHHHHHCCCHHH	53.77	29967540
177	Acetylation	DKYIQGLKNNMNCEA HHHHHHHHHCCCHHH	53.77	20167786
218	Phosphorylation	LLFQEKLTFLLHAAL HHHHHHHHHHHHHHH	24.25	25072903
226	Phosphorylation	FLLHAALSYTPVEVK HHHHHHHCCCCEECC	23.41	25072903
227	Phosphorylation	LLHAALSYTPVEVKE HHHHHHCCCCEECCC	18.86	25072903
228	Phosphorylation	LHAALSYTPVEVKES HHHHHCCCCEECCCC	19.92	25072903
248	Phosphorylation	RDINRFLSVASLQGL HHHHHHHHHHHHHHH	16.96	24043423
251	Phosphorylation	NRFLSVASLQGLIHE HHHHHHHHHHHHHCH	21.04	24043423
260	Phosphorylation	QGLIHEGTMTSLCMA HHHHCHHHHHHHHHH	17.81	24043423
262	Phosphorylation	LIHEGTMTSLCMAMT HHCHHHHHHHHHHCC	20.56	24043423
263	Phosphorylation	IHEGTMTSLCMAMTE HCHHHHHHHHHHCCH	14.56	24043423
269	Phosphorylation	TSLCMAMTEEQHKSV HHHHHHCCHHHHCCE	27.17	24043423
275	Phosphorylation	MTEEQHKSVVIDCSS CCHHHHCCEEEECCC	21.35	30177828
281	Phosphorylation	KSVVIDCSSSQPQFC CCEEEECCCCCCCCC	29.31	30177828
282	Phosphorylation	SVVIDCSSSQPQFCN CEEEECCCCCCCCCC	39.05	30177828
283	Phosphorylation	VVIDCSSSQPQFCNA EEEECCCCCCCCCCC	29.59	30177828
325	Ubiquitination	VLENFKLKAIQDTNN HHHHCCCEEEECCCH	43.99	29967540
330	Phosphorylation	KLKAIQDTNNLKRFI CCEEEECCCHHHHHH	15.05	-
334	2-Hydroxyisobutyrylation	IQDTNNLKRFIRQAE EECCCHHHHHHHHHH	47.59	-
334	Ubiquitination	IQDTNNLKRFIRQAE EECCCHHHHHHHHHH	47.59	29967540
365	Ubiquitination	GSGDILLKIVKVEHE CCCCEEEEEEEECHH	41.84	29967540
378	Ubiquitination	HEEMPEAKNVIAVLE HHHCHHHHHHHHHHH	50.51	29967540
395	Phosphorylation	MKEALDQSF------ HHHHHHHCC------	32.37	28176443

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NJMU_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NJMU_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NJMU_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WDR11_HUMAN	WDR11	physical	26186194
F91A1_HUMAN	FAM91A1	physical	26186194
F91A1_HUMAN	FAM91A1	physical	28514442
WDR11_HUMAN	WDR11	physical	28514442
AIFM1_HUMAN	AIFM1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-395, AND MASSSPECTROMETRY.
PubMed: 19413330