WDR11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR11_HUMAN
• UniProt AC: Q9BZH6
• Protein Name: WD repeat-containing protein 11
• Gene Name: WDR11
• Organism: Homo sapiens (Human).
• Sequence Length: 1224
• Subcellular Localization: Membrane ; Single-pass membrane protein . Cytoplasm . Nucleus . Might be shuttling between the nucleus and the cytoplasm.
• Protein Sequence: MLPYTVNFKVSARTLTGALNAHNKAAVDWGWQGLIAYGCHSLVVVIDSITAQTLQVLEKHKADVVKVKWARENYHHNIGSPYCLRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWLWNQDASRDLLLAIHPPNYIVLWNADTGTKLWKKSYADNILSFSFDPFDPSHLTLLTSEGIVFISDFSPSKPPSGPGKKVYISSPHSSPAHNKLATATGAKKALNKVKILITQEKPSAEFITLNDCLQLAYLPSKRNHMLLLYPREILILDLEVNQTVGVIAIERTGVPFLQVIPCFQRDGLFCLHENGCITLRVRRSYNNIFTTSNEEPDPDPVQELTYDLRSQCDAIRVTKTVRPFSMVCCPVNENAAALVVSDGRVMIWELKSAVCNRNSRNSSSGVSPLYSPVSFCGIPVGVLQNKLPDLSLDNMIGQSAIAGEEHPRGSILREVHLKFLLTGLLSGLPAPQFAIRMCPPLTTKNIKMYQPLLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLSFATSTPNNMGLVRNELQLVDLPTGRSIAFRGERGNDESAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKNFPTITALEWSPSHNLKSLRKKQLATREAMARQTVVSDTELSIVESSVISLLQEAESKSELSQNISAREHFVFTDIDGQVYHLTVEGNSVKDSARIPPDGSMGSITCIAWKGDTLVLGDMDGNLNFWDLKGRVSRGIPTHRSWVRKIRFAPGKGNQKLIAMYNDGAEVWDTKEVQMVSSLRSGRNVTFRILDVDWCTSDKVILASDDGCIRVLEMSMKSACFRMDEQELTEPVWCPYLLVPRASLALKAFLLHQPWNGQYSLDISHVDYPENEEIKNLLQEQLNSLSNDIKKLLLDPEFTLLQRCLLVSRLYGDESELHFWTVAAHYLHSLSQEKSASTTAPKEAAPRDKLSNPLDICYDVLCENAYFQKFQLERVNLQEVKRSTYDHTRKCTDQLLLLGQTDRAVQLLLETSADNQHYYCDSLKACLVTTVTSSGPSQSTIKLVATNMIANGKLAEGVQLLCLIDKAADACRYLQTYGEWNRAAWLAKVRLNPEECADVLRRWVDHLCSPQVNQKSKALLVLLSLGCFFSVAETLHSMRYFDRAALFVEACLKYGAFEVTEDTEKLITAIYADYARSLKNLGFKQGAVLFASKAGAAGKDLLNELESPKEEPIEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MLPYTVNFKVS ----CCCEEEEEEEE	35.64	21945579
5	Phosphorylation	---MLPYTVNFKVSA ---CCCEEEEEEEEE	13.66	21945579
9	Ubiquitination	LPYTVNFKVSARTLT CCEEEEEEEEEHHHH	30.03	32015554
11	Phosphorylation	YTVNFKVSARTLTGA EEEEEEEEEHHHHHH	16.78	27135362
137	Ubiquitination	DLLLAIHPPNYIVLW CEEEEECCCCEEEEE	16.84	21890473
179	Ubiquitination	SHLTLLTSEGIVFIS HHHEEEEECCEEEEE	33.52	21890473
200	Ubiquitination	PPSGPGKKVYISSPH CCCCCCCEEEEECCC	46.30	29967540
202	Phosphorylation	SGPGKKVYISSPHSS CCCCCEEEEECCCCC	12.17	23403867
204	Phosphorylation	PGKKVYISSPHSSPA CCCEEEEECCCCCHH	21.82	23927012
205	Phosphorylation	GKKVYISSPHSSPAH CCEEEEECCCCCHHH	19.64	23927012
208	Phosphorylation	VYISSPHSSPAHNKL EEEECCCCCHHHHHH	41.21	25159151
209	Phosphorylation	YISSPHSSPAHNKLA EEECCCCCHHHHHHH	24.07	23927012
214	Ubiquitination	HSSPAHNKLATATGA CCCHHHHHHHHHHHH	29.63	29967540
217	Phosphorylation	PAHNKLATATGAKKA HHHHHHHHHHHHHHH	34.88	29691806
219	Phosphorylation	HNKLATATGAKKALN HHHHHHHHHHHHHHH	33.06	24275569
222	2-Hydroxyisobutyrylation	LATATGAKKALNKVK HHHHHHHHHHHHCCE	39.67	-
255	Phosphorylation	LQLAYLPSKRNHMLL HHHHCCCCCCCCEEE	41.47	24719451
267	Ubiquitination	MLLLYPREILILDLE EEEECCCEEEEEEEE	37.33	22817900
290	Ubiquitination	AIERTGVPFLQVIPC EEECCCCCEEEEEEC	26.10	27667366
309	Ubiquitination	GLFCLHENGCITLRV CEEEEECCCEEEEEE	39.63	22817900
332	Ubiquitination	TTSNEEPDPDPVQEL ECCCCCCCCCCCHHH	64.61	27667366
349	Ubiquitination	DLRSQCDAIRVTKTV HHHHHCCEEEECCCC	10.10	21890473
354	Ubiquitination	CDAIRVTKTVRPFSM CCEEEECCCCCCCCE	42.01	-
394	Phosphorylation	SAVCNRNSRNSSSGV HHHHCCCCCCCCCCC	29.60	21712546
397	Phosphorylation	CNRNSRNSSSGVSPL HCCCCCCCCCCCCCC	25.44	21945579
398	Phosphorylation	NRNSRNSSSGVSPLY CCCCCCCCCCCCCCC	34.36	21945579
399	Phosphorylation	RNSRNSSSGVSPLYS CCCCCCCCCCCCCCC	42.93	21945579
402	Phosphorylation	RNSSSGVSPLYSPVS CCCCCCCCCCCCCCC	16.83	21945579
405	Phosphorylation	SSGVSPLYSPVSFCG CCCCCCCCCCCCCCC	17.82	21945579
406	Phosphorylation	SGVSPLYSPVSFCGI CCCCCCCCCCCCCCC	26.89	21945579
409	Phosphorylation	SPLYSPVSFCGIPVG CCCCCCCCCCCCCHH	20.43	21945579
426	Phosphorylation	QNKLPDLSLDNMIGQ CCCCCCCCHHHCCCC	40.85	25693802
428	Ubiquitination	KLPDLSLDNMIGQSA CCCCCCHHHCCCCHH	39.00	22817900
429	Ubiquitination	LPDLSLDNMIGQSAI CCCCCHHHCCCCHHH	29.30	21890473
470	Ubiquitination	LPAPQFAIRMCPPLT CCCCHHHHHHCCCCC	2.81	22817900
471	Ubiquitination	PAPQFAIRMCPPLTT CCCHHHHHHCCCCCC	19.74	21890473
479	Ubiquitination	MCPPLTTKNIKMYQP HCCCCCCCCCEEECC	51.98	22817900
500	Phosphorylation	SNGSVLVYHLTSGLL CCCCEEEEEECCCCC	6.22	-
502	Ubiquitination	GSVLVYHLTSGLLHK CCEEEEEECCCCCCC	1.92	27667366
503	Phosphorylation	SVLVYHLTSGLLHKE CEEEEEECCCCCCCC	13.87	-
504	Phosphorylation	VLVYHLTSGLLHKEL EEEEEECCCCCCCCE	33.53	-
512	Phosphorylation	GLLHKELSIHSCEVK CCCCCCEEECCCEEC	21.24	22210691
515	Phosphorylation	HKELSIHSCEVKGIE CCCEEECCCEECCEE	15.42	25159151
531	Phosphorylation	TSLTSFLSFATSTPN EEHHHHHHHHCCCCC	15.72	22210691
535	Phosphorylation	SFLSFATSTPNNMGL HHHHHHCCCCCCCCC	38.14	22210691
550	Ubiquitination	VRNELQLVDLPTGRS CCCEEEEEECCCCCE	4.60	21890473
599	Phosphorylation	LELWDVRTCTLLREM CCHHCHHHHHHHHHH	15.08	-
608	Ubiquitination	TLLREMSKNFPTITA HHHHHHHHCCCCEEE	62.39	21890473
612	Phosphorylation	EMSKNFPTITALEWS HHHHCCCCEEEEECC	27.16	26434776
614	Phosphorylation	SKNFPTITALEWSPS HHCCCCEEEEECCCC	27.89	26434776
619	Phosphorylation	TITALEWSPSHNLKS CEEEEECCCCCCHHH	13.72	25159151
621	Phosphorylation	TALEWSPSHNLKSLR EEEECCCCCCHHHHH	21.35	28857561
626	Phosphorylation	SPSHNLKSLRKKQLA CCCCCHHHHHHHHHH	36.25	28464451
626	Ubiquitination	SPSHNLKSLRKKQLA CCCCCHHHHHHHHHH	36.25	27667366
640	Ubiquitination	ATREAMARQTVVSDT HHHHHHHHCCCCCCC	21.44	22817900
641	Ubiquitination	TREAMARQTVVSDTE HHHHHHHCCCCCCCC	29.16	21890473
642	Phosphorylation	REAMARQTVVSDTEL HHHHHHCCCCCCCCH	19.81	25159151
645	Phosphorylation	MARQTVVSDTELSIV HHHCCCCCCCCHHHH	34.18	25159151
647	Phosphorylation	RQTVVSDTELSIVES HCCCCCCCCHHHHHH	31.18	25159151
650	Phosphorylation	VVSDTELSIVESSVI CCCCCCHHHHHHHHH	20.53	25867546
654	Phosphorylation	TELSIVESSVISLLQ CCHHHHHHHHHHHHH	21.00	25867546
655	Phosphorylation	ELSIVESSVISLLQE CHHHHHHHHHHHHHH	15.23	29496963
658	Phosphorylation	IVESSVISLLQEAES HHHHHHHHHHHHHHC	22.37	25867546
665	Phosphorylation	SLLQEAESKSELSQN HHHHHHHCHHHHHHC	48.83	25867546
668	Ubiquitination	QEAESKSELSQNISA HHHHCHHHHHHCCCC	57.06	27667366
680	Ubiquitination	ISAREHFVFTDIDGQ CCCCCCEEEEECCCC	5.64	22817900
703	Ubiquitination	NSVKDSARIPPDGSM CCEECCEECCCCCCC	45.99	27667366
717	Ubiquitination	MGSITCIAWKGDTLV CCEEEEEEECCCEEE	12.22	22817900
722	Ubiquitination	CIAWKGDTLVLGDMD EEEECCCEEEEECCC	27.68	21890473
738	Methylation	NLNFWDLKGRVSRGI CCCCCCCCCCHHCCC	42.04	-
738	Ubiquitination	NLNFWDLKGRVSRGI CCCCCCCCCCHHCCC	42.04	22817900
759	Ubiquitination	VRKIRFAPGKGNQKL HHHEEECCCCCCCEE	42.17	22817900
761	Ubiquitination	KIRFAPGKGNQKLIA HEEECCCCCCCEEEE	54.34	27667366
764	Ubiquitination	FAPGKGNQKLIAMYN ECCCCCCCEEEEEEC	51.07	21890473
765	Ubiquitination	APGKGNQKLIAMYND CCCCCCCEEEEEECC	45.95	-
780	Ubiquitination	GAEVWDTKEVQMVSS CCCEECCCCEEEEEE	54.11	-
786	Phosphorylation	TKEVQMVSSLRSGRN CCCEEEEEECCCCCC	20.50	24719451
787	Phosphorylation	KEVQMVSSLRSGRNV CCEEEEEECCCCCCE	19.18	24719451
790	Phosphorylation	QMVSSLRSGRNVTFR EEEEECCCCCCEEEE	47.61	29759185
795	Phosphorylation	LRSGRNVTFRILDVD CCCCCCEEEEEEEEE	15.67	24719451
824	Phosphorylation	CIRVLEMSMKSACFR HHHHHHHHHHHHHHC	17.43	24719451
838	Ubiquitination	RMDEQELTEPVWCPY CCCHHHCCCCCCCCH	37.17	27667366
841	Ubiquitination	EQELTEPVWCPYLLV HHHCCCCCCCCHHHH	7.18	22817900
842	Ubiquitination	QELTEPVWCPYLLVP HHCCCCCCCCHHHHH	6.51	21890473
899	Ubiquitination	NSLSNDIKKLLLDPE HHHCHHHHHHHCCHH	39.99	21906983
900	Ubiquitination	SLSNDIKKLLLDPEF HHCHHHHHHHCCHHH	44.71	21906983
917	Phosphorylation	LQRCLLVSRLYGDES HHHHHHHHHHHCCCH	19.28	24719451
929	Ubiquitination	DESELHFWTVAAHYL CCHHHHHHHHHHHHH	4.53	22817900
934	Ubiquitination	HFWTVAAHYLHSLSQ HHHHHHHHHHHHHCC	18.89	21890473
951	Ubiquitination	SASTTAPKEAAPRDK CCCCCCCCCCCCHHH	58.48	29967540
958	Ubiquitination	KEAAPRDKLSNPLDI CCCCCHHHCCCHHHH	55.91	29967540
960	Phosphorylation	AAPRDKLSNPLDICY CCCHHHCCCHHHHHH	41.99	28450419
967	Phosphorylation	SNPLDICYDVLCENA CCHHHHHHHHHCCCC	14.93	28450419
978	Ubiquitination	CENAYFQKFQLERVN CCCCHHHHHCEEECC	25.77	-
990	Ubiquitination	RVNLQEVKRSTYDHT ECCHHHHHHCCCHHH	39.62	29967540
999	Ubiquitination	STYDHTRKCTDQLLL CCCHHHHHHHHHHHH	42.51	-
1027	Phosphorylation	TSADNQHYYCDSLKA CCCCCCCEECCCCEE	8.95	22817900
1039	Ubiquitination	LKACLVTTVTSSGPS CEEEEEEEECCCCCC	17.82	27667366
1041	Phosphorylation	ACLVTTVTSSGPSQS EEEEEEECCCCCCHH	18.32	25693802
1042	Phosphorylation	CLVTTVTSSGPSQST EEEEEECCCCCCHHH	29.03	25693802
1043	Phosphorylation	LVTTVTSSGPSQSTI EEEEECCCCCCHHHE	45.41	25693802
1046	Phosphorylation	TVTSSGPSQSTIKLV EECCCCCCHHHEEEE	40.04	25693802
1048	Phosphorylation	TSSGPSQSTIKLVAT CCCCCCHHHEEEEEE	36.12	25693802
1049	Phosphorylation	SSGPSQSTIKLVATN CCCCCHHHEEEEEEC	17.94	25693802
1086	Phosphorylation	ACRYLQTYGEWNRAA HHHHHHHHCHHHHHH	10.49	19060867
1097	Ubiquitination	NRAAWLAKVRLNPEE HHHHHHHHCCCCHHH	26.22	27667366
1125	Phosphorylation	SPQVNQKSKALLVLL CCCCCHHHHHHHHHH	17.25	-
1130	Ubiquitination	QKSKALLVLLSLGCF HHHHHHHHHHHHHHH	5.41	22817900
1135	Ubiquitination	LLVLLSLGCFFSVAE HHHHHHHHHHHHHHH	11.65	21890473
1177	Phosphorylation	EDTEKLITAIYADYA CCHHHHHHHHHHHHH	19.89	29083192
1180	Phosphorylation	EKLITAIYADYARSL HHHHHHHHHHHHHHH	7.31	29083192
1183	Phosphorylation	ITAIYADYARSLKNL HHHHHHHHHHHHHHC	8.85	29083192
1186	Phosphorylation	IYADYARSLKNLGFK HHHHHHHHHHHCCCC	35.21	29083192
1188	Ubiquitination	ADYARSLKNLGFKQG HHHHHHHHHCCCCCC	51.91	22817900
1193	Ubiquitination	SLKNLGFKQGAVLFA HHHHCCCCCCEEEEE	46.13	21906983
1201	Phosphorylation	QGAVLFASKAGAAGK CCEEEEEECCCHHCH	18.72	-
1202	Ubiquitination	GAVLFASKAGAAGKD CEEEEEECCCHHCHH	47.62	-
1208	Ubiquitination	SKAGAAGKDLLNELE ECCCHHCHHHHHHCC	40.24	29967540
1216	Phosphorylation	DLLNELESPKEEPIE HHHHHCCCCCCCCCC	54.63	25159151
1218	Ubiquitination	LNELESPKEEPIEE- HHHCCCCCCCCCCC-	81.58	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NAA40_HUMAN	NAA40	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• : Note=A chromosomal aberration involving WDR11 is found in a form of glioblastoma. Translocation t(10
• : 19)(q26
• : q13.3) with ZNF320.
• 614858:
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-402 AND SER-406, ANDMASS SPECTROMETRY.
PubMed: 18691976