NAA40_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NAA40_HUMAN
• UniProt AC: Q86UY6
• Protein Name: N-alpha-acetyltransferase 40 {ECO:0000303|PubMed:19660095, ECO:0000312|HGNC:HGNC:25845}
• Gene Name: NAA40 {ECO:0000303|PubMed:19660095, ECO:0000312|HGNC:HGNC:25845}
• Organism: Homo sapiens (Human).
• Sequence Length: 237
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A. [PubMed: 21935442]
• Protein Sequence: MGRKSSKAKEKKQKRLEERAAMDAVCAKVDAANRLGDPLEAFPVFKKYDRNGLNVSIECKRVSGLEPATVDWAFDLTKTNMQTMYEQSEWGWKDREKREEMTDDRAWYLIAWENSSVPVAFSHFRFDVECGDEVLYCYEVQLESKVRRKGLGKFLIQILQLMANSTQMKKVMLTVFKHNHGAYQFFREALQFEIDDSSPSMSGCCGEDCSYEILSRRTKFGDSHHSHAGGHCGGCCH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGRKSSKAK ------CCCCCHHHH	45.80	-
14	Acetylation	KAKEKKQKRLEERAA HHHHHHHHHHHHHHH	68.76	90633
25	Ubiquitination	ERAAMDAVCAKVDAA HHHHHHHHHHHHHHH	2.58	-
26	Ubiquitination	RAAMDAVCAKVDAAN HHHHHHHHHHHHHHH	3.04	-
28	Ubiquitination	AMDAVCAKVDAANRL HHHHHHHHHHHHHHC	35.21	-
46	Ubiquitination	LEAFPVFKKYDRNGL HHHCCCCCEECCCCC	51.13	-
47	Ubiquitination	EAFPVFKKYDRNGLN HHCCCCCEECCCCCE	40.70	-
56	Phosphorylation	DRNGLNVSIECKRVS CCCCCEEEEEEEECC	16.17	25159151
165	Phosphorylation	ILQLMANSTQMKKVM HHHHHHCCCCHHHHH	15.52	21406692
166	Phosphorylation	LQLMANSTQMKKVML HHHHHCCCCHHHHHH	32.27	21406692
174	Phosphorylation	QMKKVMLTVFKHNHG CHHHHHHHHHHCCCH	13.05	20068231
183	Phosphorylation	FKHNHGAYQFFREAL HHCCCHHHHHHHHHH	15.50	25278378
215	Phosphorylation	DCSYEILSRRTKFGD CCCHHHHHCCCCCCC	25.94	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NAA40_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NAA40_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NAA40_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RL40_HUMAN	UBA52	physical	28514442
PARP2_HUMAN	PARP2	physical	28514442
ANGE2_HUMAN	ANGEL2	physical	28514442
SP16H_HUMAN	SUPT16H	physical	28514442
MAP11_HUMAN	METAP1	physical	28514442
XPC_HUMAN	XPC	physical	28514442
TPP2_HUMAN	TPP2	physical	28514442
SSRP1_HUMAN	SSRP1	physical	28514442
H2AY_HUMAN	H2AFY	physical	28514442
ATG7_HUMAN	ATG7	physical	28514442
GLRX3_HUMAN	GLRX3	physical	28514442
H2A2B_HUMAN	HIST2H2AB	physical	28514442
MCM2_HUMAN	MCM2	physical	28514442
H4_HUMAN	HIST1H4I	physical	25619998
H2A2C_HUMAN	HIST2H2AC	physical	25619998

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.