| UniProt ID | KCNK3_HUMAN | |
|---|---|---|
| UniProt AC | O14649 | |
| Protein Name | Potassium channel subfamily K member 3 | |
| Gene Name | KCNK3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 394 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . |
|
| Protein Description | pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.. | |
| Protein Sequence | MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRRCLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 53 | N-linked_Glycosylation | QELRARYNLSQGGYE HHHHHHHCCCCCCHH | 27.88 | UniProtKB CARBOHYD | |
| 64 | Methylation | GGYEELERVVLRLKP CCHHHHHHHHHHHCC | 36.15 | 24383347 | |
| 113 | Phosphorylation | GKVFCMFYALLGIPL HHHHHHHHHHHCCCH | 3.02 | 25850435 | |
| 281 | Phosphorylation | GGGGSAHTTDTASST CCCCCCCCCCCCCCC | 26.53 | 22210691 | |
| 286 | Phosphorylation | AHTTDTASSTAAAGG CCCCCCCCCCCCCCC | 30.25 | 22210691 | |
| 288 | Phosphorylation | TTDTASSTAAAGGGG CCCCCCCCCCCCCCC | 20.16 | 22210691 | |
| 300 | Phosphorylation | GGGFRNVYAEVLHFQ CCCHHHHHHHHHHHH | 10.70 | - | |
| 308 | Phosphorylation | AEVLHFQSMCSCLWY HHHHHHHHHHHHHHH | 22.32 | 28787133 | |
| 311 | Phosphorylation | LHFQSMCSCLWYKSR HHHHHHHHHHHHHCH | 12.00 | 28787133 | |
| 315 | Phosphorylation | SMCSCLWYKSREKLQ HHHHHHHHHCHHHHH | 6.02 | - | |
| 323 | Phosphorylation | KSREKLQYSIPMIIP HCHHHHHCCCCEEEC | 21.00 | 25884760 | |
| 334 | Phosphorylation | MIIPRDLSTSDTCVE EEECCCCCCCCCEEE | 30.10 | 27732954 | |
| 335 | Phosphorylation | IIPRDLSTSDTCVEQ EECCCCCCCCCEEEC | 37.61 | 27732954 | |
| 336 | Phosphorylation | IPRDLSTSDTCVEQS ECCCCCCCCCEEECC | 27.78 | 27732954 | |
| 338 | Phosphorylation | RDLSTSDTCVEQSHS CCCCCCCCEEECCCC | 20.44 | 27732954 | |
| 343 | Phosphorylation | SDTCVEQSHSSPGGG CCCEEECCCCCCCCC | 16.30 | 27732954 | |
| 345 | Phosphorylation | TCVEQSHSSPGGGGR CEEECCCCCCCCCCC | 43.40 | 27732954 | |
| 346 | Phosphorylation | CVEQSHSSPGGGGRY EEECCCCCCCCCCCC | 23.34 | 27732954 | |
| 358 | Phosphorylation | GRYSDTPSRRCLCSG CCCCCCCCCCCCCCC | 34.15 | 22817900 | |
| 364 | Phosphorylation | PSRRCLCSGAPRSAI CCCCCCCCCCCHHHH | 25.66 | - | |
| 369 | Phosphorylation | LCSGAPRSAISSVST CCCCCCHHHHHHHHH | 28.97 | - | |
| 372 | Phosphorylation | GAPRSAISSVSTGLH CCCHHHHHHHHHHHH | 25.14 | 28348404 | |
| 373 | Phosphorylation | APRSAISSVSTGLHS CCHHHHHHHHHHHHH | 17.61 | 28857561 | |
| 375 | Phosphorylation | RSAISSVSTGLHSLS HHHHHHHHHHHHHHH | 20.78 | 25921289 | |
| 383 | Phosphorylation | TGLHSLSTFRGLMKR HHHHHHHHHHHHHHH | 23.73 | 22817900 | |
| 392 | Phosphorylation | RGLMKRRSSV----- HHHHHHHCCC----- | 39.21 | - | |
| 393 | Phosphorylation | GLMKRRSSV------ HHHHHHCCC------ | 29.99 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 336 | S | Phosphorylation | Kinase | ROCK1 | Q13464 | PSP |
| 383 | T | Phosphorylation | Kinase | PRKCE | Q02156 | GPS |
| 393 | S | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
| 393 | S | Phosphorylation | Kinase | RPS6KA3 | P51812 | GPS |
| 393 | S | Phosphorylation | Kinase | ROCK1 | Q13464 | PSP |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KCNK3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KCNK3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| S10AA_HUMAN | S100A10 | physical | 12198146 | |
| 1433B_HUMAN | YWHAB | physical | 12437930 | |
| COPB_HUMAN | COPB1 | physical | 12437930 | |
| COPB_HUMAN | COPB1 | physical | 23772394 | |
| 1433B_HUMAN | YWHAB | physical | 23772394 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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