HSPB7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HSPB7_HUMAN
• UniProt AC: Q9UBY9
• Protein Name: Heat shock protein beta-7
• Gene Name: HSPB7
• Organism: Homo sapiens (Human).
• Sequence Length: 170
• Subcellular Localization: Cytoplasm . Nucleus . Nucleus, Cajal body . Resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
• Protein Sequence: MSHRTSSTFRAERSFHSSSSSSSSSTSSSASRALPAQDPPMEKALSMFSDDFGSFMRPHSEPLAFPARPGGAGNIKTLGDAYEFAVDVRDFSPEDIIVTTSNNHIEVRAEKLAADGTVMNTFAHKCQLPEDVDPTSVTSALREDGSLTIRARRHPHTEHVQQTFRTEIKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MSHRTSSTFRAE ---CCCCCCCCEEEE	22.93	26437602
6	Phosphorylation	--MSHRTSSTFRAER --CCCCCCCCEEEEE	27.60	26437602
7	Phosphorylation	-MSHRTSSTFRAERS -CCCCCCCCEEEEEE	30.84	26437602
8	Phosphorylation	MSHRTSSTFRAERSF CCCCCCCCEEEEEEC	19.53	26437602
14	Phosphorylation	STFRAERSFHSSSSS CCEEEEEECCCCCCC	20.86	26437602
17	Phosphorylation	RAERSFHSSSSSSSS EEEEECCCCCCCCCC	29.88	23312004
18	Phosphorylation	AERSFHSSSSSSSSS EEEECCCCCCCCCCC	26.18	23312004
19	Phosphorylation	ERSFHSSSSSSSSST EEECCCCCCCCCCCC	36.94	23312004
20	Phosphorylation	RSFHSSSSSSSSSTS EECCCCCCCCCCCCC	35.87	23312004
21	Phosphorylation	SFHSSSSSSSSSTSS ECCCCCCCCCCCCCC	35.87	23312004
22	Phosphorylation	FHSSSSSSSSSTSSS CCCCCCCCCCCCCCC	35.87	23312004
23	Phosphorylation	HSSSSSSSSSTSSSA CCCCCCCCCCCCCCH	30.20	23312004
24	Phosphorylation	SSSSSSSSSTSSSAS CCCCCCCCCCCCCHH	39.31	23312004
46	Phosphorylation	PPMEKALSMFSDDFG CCHHHHHHHHCCCCH	23.73	26437602
46 (in isoform 2)	Phosphorylation	-	23.73	26437602
60	Phosphorylation	GSFMRPHSEPLAFPA HHCCCCCCCCCCCCC	43.52	26437602
92	Phosphorylation	AVDVRDFSPEDIIVT EEECCCCCHHHEEEE	31.50	26657352

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HSPB7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HSPB7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HSPB7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSPB8_HUMAN	HSPB8	physical	14594798
A4_HUMAN	APP	physical	21832049
PRD14_HUMAN	PRDM14	physical	25416956
PKHF2_HUMAN	PLEKHF2	physical	25416956
CEP76_HUMAN	CEP76	physical	25416956
SYCE1_HUMAN	SYCE1	physical	25416956
FLNC_HUMAN	FLNC	physical	28514442
FLNA_HUMAN	FLNA	physical	28514442
FLNB_HUMAN	FLNB	physical	28514442
BPTF_HUMAN	BPTF	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.