dbPTM

RFLA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RFLA_HUMAN
UniProt AC	Q6ZTI6
Protein Name	Refilin-A
Gene Name	RFLNA {ECO:0000312\|HGNC:HGNC:27051}
Organism	Homo sapiens (Human).
Sequence Length	216
Subcellular Localization	Cytoplasm, cytoskeleton . Colocalizes with FLNA along actin bundle-like structures.
Protein Description	Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing cartilaginous cells..
Protein Sequence	MVGHLHLQGMEDSLKEQGREGLLDSPDSGLPPSPSPSPPFYSLAPGILDARAGGAGASSEPPGPSEARAPPSQLPNPPASEMRPRMLPVFFGESIKVNPEPTHEIRCNSEVKYASEKHFQDKVFYAPVPTVTAYSETIVAAPNCTWRNYRSQLTLEPRPRALRFRSTTIIFPKHARSTFRTTLHCSLGRPSRWFTASVQLQLCQDPAPSLLGPATL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
25	Phosphorylation	GREGLLDSPDSGLPP CCCCCCCCCCCCCCC	26657352
28	Phosphorylation	GLLDSPDSGLPPSPS CCCCCCCCCCCCCCC	26657352
33	Phosphorylation	PDSGLPPSPSPSPPF CCCCCCCCCCCCCCC	26657352
35	Phosphorylation	SGLPPSPSPSPPFYS CCCCCCCCCCCCCHH	26657352
37	Phosphorylation	LPPSPSPSPPFYSLA CCCCCCCCCCCHHCC	26657352
41	Phosphorylation	PSPSPPFYSLAPGIL CCCCCCCHHCCCCEE	29038488
163	Methylation	EPRPRALRFRSTTII CCCCCCCCEEEEEEE	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RFLA_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RFLA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RFLA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RFLA_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RFLA_HUMAN

Related Literatures of Post-Translational Modification