| UniProt ID | KCNE4_HUMAN | |
|---|---|---|
| UniProt AC | Q8WWG9 | |
| Protein Name | Potassium voltage-gated channel subfamily E member 4 | |
| Gene Name | KCNE4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 221 | |
| Subcellular Localization |
Membrane Single-pass membrane protein . |
|
| Protein Description | Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current.. | |
| Protein Sequence | MHFLTIYPNCSSGVVRAQSRTEQKNPLGLDDLGIQNLGQTVSLAPAVEAASMLKMEPLNSTHPGTAASSSPLESRAAGGGSGNGNEYFYILVVMSFYGIFLIGIMLGYMKSKRREKKSSLLLLYKDEERLWGEAMKPLPVVSGLRSVQVPLMLNMLQESVAPALSCTLCSMEGDSVSSESSSPDVHLTIQEEGADDELEETSETPLNESSEGSSENIHQNS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | N-linked_Glycosylation | HFLTIYPNCSSGVVR CEEEECCCCCCCCCC | 35.46 | UniProtKB CARBOHYD | |
| 68 | Phosphorylation | THPGTAASSSPLESR CCCCCCCCCCCCCCC | 31.73 | 24719451 | |
| 73 | Phosphorylation | AASSSPLESRAAGGG CCCCCCCCCCCCCCC | 19.16 | 24719451 | |
| 118 | Phosphorylation | SKRREKKSSLLLLYK HHCCCCCCCEEEEEE | 1.64 | 28348404 | |
| 119 | Phosphorylation | KRREKKSSLLLLYKD HCCCCCCCEEEEEEC | 23.99 | 23312004 | |
| 124 | Phosphorylation | KSSLLLLYKDEERLW CCCEEEEEECHHHHH | 34.45 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KCNE4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KCNE4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KCNE4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KCND2_HUMAN | KCND2 | physical | 20498229 | |
| KCIP2_HUMAN | KCNIP2 | physical | 20498229 | |
| FLNA_HUMAN | FLNA | physical | 20498229 | |
| OBSL1_HUMAN | OBSL1 | physical | 20498229 | |
| TSNAX_HUMAN | TSNAX | physical | 20498229 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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