CASR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CASR_HUMAN
• UniProt AC: P41180
• Protein Name: Extracellular calcium-sensing receptor {ECO:0000305}
• Gene Name: CASR {ECO:0000312|HGNC:HGNC:1514}
• Organism: Homo sapiens (Human).
• Sequence Length: 1078
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. [PubMed: 7759551]
• Protein Sequence: MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGETDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVVNS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	N-linked_Glycosylation	SSPALLPNLTLGYRI CCCCCCCCCCCCCEE	45.70	9852126
90	N-linked_Glycosylation	SSPALLPNLTLGYRI CCCCCCCCCCCCCEE	45.70	9852126
130	N-linked_Glycosylation	LNLDEFCNCSEHIPS CCHHHHCCCCCCCCC	37.36	9852126
130	N-linked_Glycosylation	LNLDEFCNCSEHIPS CCHHHHCCCCCCCCC	37.36	9852126
182	Phosphorylation	SNKNQFKSFLRTIPN CCHHHHHHHHHHCCC	30.70	24719451
186	Phosphorylation	QFKSFLRTIPNDEHQ HHHHHHHHCCCCHHH	42.82	-
195	Phosphorylation	PNDEHQATAMADIIE CCCHHHHHHHHHHHH	15.47	-
261	N-linked_Glycosylation	HVVEVIQNSTAKVIV HHHHHHHCCCCEEEE	30.15	27434672
261	N-linked_Glycosylation	HVVEVIQNSTAKVIV HHHHHHHCCCCEEEE	30.15	27434672
287	N-linked_Glycosylation	IKEIVRRNITGKIWL HHHHHHCCCCCCEEE	26.13	27434672
287	N-linked_Glycosylation	IKEIVRRNITGKIWL HHHHHHCCCCCCEEE	26.13	27434672
336	Acetylation	GFREFLKKVHPRKSV CHHHHHHHHCCCCCC	48.17	30587449
342	Phosphorylation	KKVHPRKSVHNGFAK HHHCCCCCCCCCCHH	29.86	16674116
386	N-linked_Glycosylation	ESGDRFSNSSTAFRP CCCCCCCCCCCCCCC	36.95	UniProtKB CARBOHYD
400	N-linked_Glycosylation	PLCTGDENISSVETP CCCCCCCCCCCCCCC	44.15	UniProtKB CARBOHYD
446	N-linked_Glycosylation	PGRGLFTNGSCADIK CCCCCCCCCCCCCHH	32.80	27434672
446	N-linked_Glycosylation	PGRGLFTNGSCADIK CCCCCCCCCCCCCHH	32.80	27434672
468	N-linked_Glycosylation	LKHLRHLNFTNNMGE HHHHHHCCCCCCCCC	35.25	27434672
468	N-linked_Glycosylation	LKHLRHLNFTNNMGE HHHHHHCCCCCCCCC	35.25	27434672
488	N-linked_Glycosylation	ECGDLVGNYSIINWH HCCCEECCEEEEEEE	21.65	27434672
488	N-linked_Glycosylation	ECGDLVGNYSIINWH HCCCEECCEEEEEEE	21.65	27434672
541	N-linked_Glycosylation	SREVPFSNCSRDCLA CCCCCCCCCCCCCCC	28.32	27434672
594	N-linked_Glycosylation	DDFWSNENHTSCIAK CCCCCCCCCCHHHHH	48.24	27434672
794	Phosphorylation	CFFFAFKSRKLPENF HHHHHHHCCCCCCCC	28.35	29083192
875	Phosphorylation	TIEEVRCSTAAHAFK CCCHHHHHHHHHHHH	15.54	-
888	Phosphorylation	FKVAARATLRRSNVS HHHHHHHHHHHHCCC	18.42	20233724
892	Phosphorylation	ARATLRRSNVSRKRS HHHHHHHHCCCCCCC	34.84	20798521
895	Phosphorylation	TLRRSNVSRKRSSSL HHHHHCCCCCCCCCC	36.01	23911959
899	Phosphorylation	SNVSRKRSSSLGGST HCCCCCCCCCCCCCC	27.58	20798521
900	Phosphorylation	NVSRKRSSSLGGSTG CCCCCCCCCCCCCCC	33.35	28857561
901	Phosphorylation	VSRKRSSSLGGSTGS CCCCCCCCCCCCCCC	32.07	26657352
906	Phosphorylation	SSSLGGSTGSTPSSS CCCCCCCCCCCCCCC	38.13	-
912	Phosphorylation	STGSTPSSSISSKSN CCCCCCCCCCCCCCC	32.66	26437602
913	Phosphorylation	TGSTPSSSISSKSNS CCCCCCCCCCCCCCC	30.72	26437602
915	Phosphorylation	STPSSSISSKSNSED CCCCCCCCCCCCCCC	33.39	9694886
920	Phosphorylation	SISSKSNSEDPFPQP CCCCCCCCCCCCCCH	50.93	-
997	Phosphorylation	RNSTHQNSLEAQKSS CCCHHHHHHHHHHCC	22.48	28857561
1061	Phosphorylation	LVVSSSQSFVISGGG EEEECCCCEEECCCC	24.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
888	T	Phosphorylation	Kinase	PRKCA	P17252	GPS
888	T	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
888	T	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	RNF19A	Q9NV58	PMID:16513638

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CASR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CASR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CASR_HUMAN	CASR	physical	9722601
FLNA_HUMAN	FLNA	physical	11390379
CHD8_HUMAN	CHD8	physical	19151705
RN19A_HUMAN	RNF19A	physical	16513638
STABP_HUMAN	STAMBP	physical	16854379
OS9_MOUSE	Os9	physical	28419469
OS9_HUMAN	OS9	physical	28419469

Drug and Disease Associations

• Kegg Disease
• H00239: Bartter syndrome
• OMIM Disease
• 145980: Hypocalciuric hypercalcemia, familial 1 (HHC1)
• 239200: Hyperparathyroidism, neonatal severe (NSHPT)
• 601198: Hypocalcemia, autosomal dominant 1 (HYPOC1)
• 612899: Epilepsy, idiopathic generalized 8 (EIG8)
• Kegg Drug
• D03504: Cinacalcet (USAN)
• D03505: Cinacalcet hydrochloride (JAN/USAN); Sensipar (TN)
• D08991: Ronacaleret hydrochloride (USAN)
• DrugBank
• DB01012: Cinacalcet