SH2B3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SH2B3_HUMAN
• UniProt AC: Q9UQQ2
• Protein Name: SH2B adapter protein 3
• Gene Name: SH2B3
• Organism: Homo sapiens (Human).
• Sequence Length: 575
• Protein Description: Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase..
• Protein Sequence: MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARSSEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAKKFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELFDPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	NGPALQPSSPSSAPS CCCCCCCCCCCCCCC	41.75	29255136
10	Phosphorylation	GPALQPSSPSSAPSA CCCCCCCCCCCCCCC	35.17	29255136
12	Phosphorylation	ALQPSSPSSAPSASP CCCCCCCCCCCCCCC	40.87	29255136
13	Phosphorylation	LQPSSPSSAPSASPA CCCCCCCCCCCCCCC	47.81	29255136
16	Phosphorylation	SSPSSAPSASPAAAP CCCCCCCCCCCCCCC	40.89	25850435
18	Phosphorylation	PSSAPSASPAAAPRG CCCCCCCCCCCCCCC	21.29	25850435
99	Ubiquitination	TGRGPPAKAEASPEP CCCCCCCCCCCCCCC	53.16	-
103	Phosphorylation	PPAKAEASPEPGPGP CCCCCCCCCCCCCCC	22.69	29255136
120	Phosphorylation	PGLPKARSSEELAPP CCCCCCCCCCCCCCC	47.14	29255136
121	Phosphorylation	GLPKARSSEELAPPR CCCCCCCCCCCCCCC	29.54	29255136
134	Phosphorylation	PRPPGPCSFQHFRRS CCCCCCCCHHHHHHH	30.95	23403867
150	Phosphorylation	RHIFRRRSAGELPAA HHHHHHCCCCCCCCC	38.52	30266825
159	Phosphorylation	GELPAAHTAAAPGTP CCCCCCEECCCCCCC	17.17	29255136
165	Phosphorylation	HTAAAPGTPGEAAET EECCCCCCCCCCCCC	27.36	29255136
172	Phosphorylation	TPGEAAETPARPGLA CCCCCCCCCCCCCHH	19.95	23403867
203	Phosphorylation	LKEAVLRYSLADEAS HHHHHHHHHHCCHHH	12.13	-
273	Phosphorylation	LEMPDNLYTFVLKVK EECCCCEEEEEEEEC	12.37	27259358
274	Phosphorylation	EMPDNLYTFVLKVKD ECCCCEEEEEEEECC	15.50	27259358
321	Phosphorylation	EAEMHIPSALEPSTS CCCEECCCCCCCCCC	44.90	28060719
326	Phosphorylation	IPSALEPSTSSSPRG CCCCCCCCCCCCCCC	31.39	25850435
327	Phosphorylation	PSALEPSTSSSPRGS CCCCCCCCCCCCCCC	43.26	29255136
328	Phosphorylation	SALEPSTSSSPRGST CCCCCCCCCCCCCCC	32.91	29255136
329	Phosphorylation	ALEPSTSSSPRGSTD CCCCCCCCCCCCCCC	44.44	29255136
330	Phosphorylation	LEPSTSSSPRGSTDS CCCCCCCCCCCCCCC	20.55	29255136
334	Phosphorylation	TSSSPRGSTDSLNQG CCCCCCCCCCCCCCC	30.26	29255136
335	Phosphorylation	SSSPRGSTDSLNQGA CCCCCCCCCCCCCCC	32.22	29255136
337	Phosphorylation	SPRGSTDSLNQGASP CCCCCCCCCCCCCCC	29.34	29255136
343	Phosphorylation	DSLNQGASPGGLLDP CCCCCCCCCCCCCCH	30.79	25850435
373	Ubiquitination	HGPISRVKAAQLVQL CCCHHHHHHHHEEEC	36.57	-
417	Phosphorylation	IAKHLRLSLTERGQC HHHHHCCHHCCCCCE	27.15	26699800
511	Phosphorylation	SGCPRGLSPEGLPGR CCCCCCCCCCCCCCC	24.59	29255136
519	Phosphorylation	PEGLPGRSSPPEQIF CCCCCCCCCCHHHHH	53.78	26074081
520	Phosphorylation	EGLPGRSSPPEQIFH CCCCCCCCCHHHHHE	43.01	26074081
538	Phosphorylation	SPEELANSLQHLEHE CHHHHHHHHHHHCCC	24.65	28464451
553	Phosphorylation	PVNRARDSDYEMDSS CCCCCCCCCCCCCCC	36.22	28985074
555	Phosphorylation	NRARDSDYEMDSSSR CCCCCCCCCCCCCCH	19.66	24114839
559	Phosphorylation	DSDYEMDSSSRSHLR CCCCCCCCCCHHHHH	28.98	24114839
560	Phosphorylation	SDYEMDSSSRSHLRA CCCCCCCCCHHHHHH	26.05	24114839
561	Phosphorylation	DYEMDSSSRSHLRAI CCCCCCCCHHHHHHH	41.58	24114839
572	Phosphorylation	LRAIDNQYTPL---- HHHHHCCCCCC----	19.31	30174305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
273	Y	Phosphorylation	Kinase	LCK	P06239	PhosphoELM
273	Y	Phosphorylation	Kinase	ZAP70	P43403	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SH2B3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
203	Phosphorylation	193 (10)	E ⇒ K	rs148636776	Plateletcrit Platelet count	27863252

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LCK_HUMAN	LCK	physical	10799879
GRB2_HUMAN	GRB2	physical	8649391
PLCG1_HUMAN	PLCG1	physical	8649391
FLNA_HUMAN	FLNA	physical	11163396

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 612011: Celiac disease 13 (CELIAC13)
• 222100: Diabetes mellitus, insulin-dependent (IDDM)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB06589: Pazopanib