ITB7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ITB7_HUMAN
• UniProt AC: P26010
• Protein Name: Integrin beta-7
• Gene Name: ITGB7
• Organism: Homo sapiens (Human).
• Sequence Length: 798
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin..
• Protein Sequence: MVALPMVLVLLLVLSRGESELDAKIPSTGDATEWRNPHLSMLGSCQPAPSCQKCILSHPSCAWCKQLNFTASGEAEARRCARREELLARGCPLEELEEPRGQQEVLQDQPLSQGARGEGATQLAPQRVRVTLRPGEPQQLQVRFLRAEGYPVDLYYLMDLSYSMKDDLERVRQLGHALLVRLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLRHPCPTRLERCQSPFSFHHVLSLTGDAQAFEREVGRQSVSGNLDSPEGGFDAILQAALCQEQIGWRNVSRLLVFTSDDTFHTAGDGKLGGIFMPSDGHCHLDSNGLYSRSTEFDYPSVGQVAQALSAANIQPIFAVTSAALPVYQELSKLIPKSAVGELSEDSSNVVQLIMDAYNSLSSTVTLEHSSLPPGVHISYESQCEGPEKREGKAEDRGQCNHVRINQTVTFWVSLQATHCLPEPHLLRLRALGFSEELIVELHTLCDCNCSDTQPQAPHCSDGQGHLQCGVCSCAPGRLGRLCECSVAELSSPDLESGCRAPNGTGPLCSGKGHCQCGRCSCSGQSSGHLCECDDASCERHEGILCGGFGRCQCGVCHCHANRTGRACECSGDMDSCISPEGGLCSGHGRCKCNRCQCLDGYYGALCDQCPGCKTPCERHRDCAECGAFRTGPLATNCSTACAHTNVTLALAPILDDGWCKERTLDNQLFFFLVEDDARGTVVLRVRPQEKGADHTQAIVLGCVGGIVAVGLGLVLAYRLSVEIYDRREYSRFEKEQQQLNWKQDSNPLYKSAITTTINPRFQEADSPTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	LVLLLVLSRGESELD HHHHHHHHCCCHHHH	30.66	24719451
19	Phosphorylation	LVLSRGESELDAKIP HHHHCCCHHHHCCCC	46.40	-
24	Ubiquitination	GESELDAKIPSTGDA CCHHHHCCCCCCCCC	55.61	-
53	Ubiquitination	QPAPSCQKCILSHPS CCCCCCCCCHHHCCC	27.80	-
65	Ubiquitination	HPSCAWCKQLNFTAS CCCCHHHHHCCCCCC	47.31	-
68	N-linked_Glycosylation	CAWCKQLNFTASGEA CHHHHHCCCCCCCHH	29.72	UniProtKB CARBOHYD
131	Phosphorylation	APQRVRVTLRPGEPQ CCCEEEEEECCCCCC	13.39	-
150	Phosphorylation	RFLRAEGYPVDLYYL EEEECCCCCEEEEEE	7.50	-
165 (in isoform 1)	Ubiquitination	-	41.99	21906983
165	Ubiquitination	MDLSYSMKDDLERVR EECCCCCCHHHHHHH	41.99	22817900
165 (in isoform 2)	Ubiquitination	-	41.99	21906983
199	Ubiquitination	GFGSFVDKTVLPFVS ECCCCCCCCCHHHCC	34.92	22817900
199 (in isoform 1)	Ubiquitination	-	34.92	21906983
199 (in isoform 2)	Ubiquitination	-	34.92	21906983
211	Ubiquitination	FVSTVPSKLRHPCPT HCCCCCHHCCCCCCC	43.39	22817900
211 (in isoform 1)	Ubiquitination	-	43.39	21906983
211 (in isoform 2)	Ubiquitination	-	43.39	21906983
279	N-linked_Glycosylation	QEQIGWRNVSRLLVF HHHHCCCCCEEEEEE	29.61	UniProtKB CARBOHYD
299 (in isoform 1)	Ubiquitination	-	49.01	21906983
299	Ubiquitination	FHTAGDGKLGGIFMP EEECCCCCEEEEECC	49.01	22817900
299 (in isoform 2)	Ubiquitination	-	49.01	21906983
320	Phosphorylation	LDSNGLYSRSTEFDY ECCCCCCCCCCCCCC	25.46	24719451
361	Ubiquitination	PVYQELSKLIPKSAV HHHHHHHHHCCHHHC	64.16	-
365	Ubiquitination	ELSKLIPKSAVGELS HHHHHCCHHHCCCCC	44.01	-
434	N-linked_Glycosylation	QCNHVRINQTVTFWV CCCCEEECCEEEEEE	22.39	UniProtKB CARBOHYD
477	N-linked_Glycosylation	LHTLCDCNCSDTQPQ HHHHHCCCCCCCCCC	18.31	UniProtKB CARBOHYD
531	N-linked_Glycosylation	ESGCRAPNGTGPLCS HCCCCCCCCCCCCCC	60.72	UniProtKB CARBOHYD
551	Phosphorylation	QCGRCSCSGQSSGHL CCCCCCCCCCCCCEE	24.47	-
590	N-linked_Glycosylation	GVCHCHANRTGRACE CCCCCCCCCCCCCCE	20.55	UniProtKB CARBOHYD
615 (in isoform 2)	Ubiquitination	-	26.69	21906983
623 (in isoform 2)	Ubiquitination	-	22.73	21906983
631 (in isoform 2)	Ubiquitination	-	11.06	21906983
642	Ubiquitination	CDQCPGCKTPCERHR CCCCCCCCCCCHHHC	62.51	22817900
642 (in isoform 1)	Ubiquitination	-	62.51	21906983
665	N-linked_Glycosylation	RTGPLATNCSTACAH CCCCCCCCCCHHCCC	16.48	UniProtKB CARBOHYD
674	N-linked_Glycosylation	STACAHTNVTLALAP CHHCCCCCCEEEEEC	18.21	UniProtKB CARBOHYD
689	Ubiquitination	ILDDGWCKERTLDNQ CCCCCCCCEEECCCE	43.66	-
753	Phosphorylation	YRLSVEIYDRREYSR HHHHEEEECHHHHHH	7.01	22817900
758	Phosphorylation	EIYDRREYSRFEKEQ EEECHHHHHHHHHHH	11.88	22817900
763 (in isoform 1)	Ubiquitination	-	59.10	21906983
763	Ubiquitination	REYSRFEKEQQQLNW HHHHHHHHHHHHCCC	59.10	22817900
771	Ubiquitination	EQQQLNWKQDSNPLY HHHHCCCCCCCCCCH	43.06	21906983
771 (in isoform 1)	Ubiquitination	-	43.06	21906983
774	Phosphorylation	QLNWKQDSNPLYKSA HCCCCCCCCCCHHHH	37.54	27080861
778	Phosphorylation	KQDSNPLYKSAITTT CCCCCCCHHHHEEEE	12.26	27080861
779	Ubiquitination	QDSNPLYKSAITTTI CCCCCCHHHHEEEEE	40.88	22817900
779 (in isoform 1)	Ubiquitination	-	40.88	21906983
780	Phosphorylation	DSNPLYKSAITTTIN CCCCCHHHHEEEEEC	16.02	27251275
783	Phosphorylation	PLYKSAITTTINPRF CCHHHHEEEEECHHH	20.01	12682249
784	Phosphorylation	LYKSAITTTINPRFQ CHHHHEEEEECHHHH	21.40	22817900
785	Phosphorylation	YKSAITTTINPRFQE HHHHEEEEECHHHHC	15.31	22817900
795	Phosphorylation	PRFQEADSPTL---- HHHHCCCCCCC----	27.17	30108239
797	Phosphorylation	FQEADSPTL------ HHCCCCCCC------	49.40	30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
753	Y	Phosphorylation	Kinase	PTK2	Q05397	GPS
753	Y	Phosphorylation	Kinase	SRC	P12931	PSP
758	Y	Phosphorylation	Kinase	PTK2	Q05397	GPS
758	Y	Phosphorylation	Kinase	SRC	P12931	PSP
778	Y	Phosphorylation	Kinase	TYR-KINASES	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ITB7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ITB7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EED_HUMAN	EED	physical	9765275

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D08083: Vedolizumab (USAN)
• D09901: Etrolizumab (USAN/INN)
• D10028: Valategrast hydrochloride (USAN)
• DrugBank
• There are no disease associations of PTM sites.